diff --git a/docs/configure.rst b/docs/configure.rst
index 91514c9de5..a1b61a1ed0 100644
--- a/docs/configure.rst
+++ b/docs/configure.rst
@@ -94,8 +94,12 @@ The valid attributes of a system are the following:
 
 * ``descr``: A detailed description of the system (default is the system name).
 * ``hostnames``: This is a list of hostname patterns that will be used by ReFrame when it tries to `auto-detect <#system-auto-detection>`__ the current system (default ``[]``).
-* ``modules_system``: The modules system that should be used for loading environment modules on this system.
-  The only available modules system backend is currently ``tmod``, which corresponds to the `TCL implementation <http://modules.sourceforge.net/>`__ of the environment modules (default :class:`None`).
+* ``modules_system``: The modules system that should be used for loading environment modules on this system (default :class:`None`).
+  Three types of modules systems are currently supported:
+
+  - ``tmod``: The classic Tcl implementation of the `environment modules <https://sourceforge.net/projects/modules/files/Modules/modules-3.2.10/>`__.
+  - ``tmod4``: The version 4 of the Tcl implementation of the `environment modules <http://modules.sourceforge.net/>`__.
+  - ``lmod``: The Lua implementation of the `environment modules <https://lmod.readthedocs.io/en/latest/>`__.
 * ``prefix``: Default regression prefix for this system (default ``.``).
 * ``stagedir``: Default stage directory for this system (default :class:`None`).
 * ``outputdir``: Default output directory for this system (default :class:`None`).
diff --git a/reframe/core/modules.py b/reframe/core/modules.py
index ff55270938..db6ed098b4 100644
--- a/reframe/core/modules.py
+++ b/reframe/core/modules.py
@@ -9,7 +9,8 @@
 
 import reframe.core.fields as fields
 import reframe.utility.os_ext as os_ext
-from reframe.core.exceptions import ConfigError, EnvironError
+from reframe.core.exceptions import (ConfigError, EnvironError,
+                                     SpawnedProcessError)
 
 
 class Module:
@@ -451,6 +452,46 @@ def emit_unload_instr(self, module):
         return 'module unload %s' % module
 
 
+class TMod4Impl(TModImpl):
+    """Module system for TMod 4."""
+
+    def __init__(self):
+        self._command = 'modulecmd python'
+        try:
+            completed = os_ext.run_command(self._command + ' -V', check=True)
+        except OSError as e:
+            raise ConfigError(
+                'could not find a sane Tmod4 installation') from e
+        except SpawnedProcessError as e:
+            raise ConfigError(
+                'could not get the Python bindings for Tmod4') from e
+
+        version_match = re.match('^Modules Release (\S+)\s+', completed.stderr)
+        if not version_match:
+            raise ConfigError('could not retrieve the TMod4 version')
+
+        self._version = version_match.group(1)
+
+    def name(self):
+        return 'tmod4'
+
+    def _exec_module_command(self, *args, msg=None):
+        command = ' '.join([self._command, *args])
+        completed = os_ext.run_command(command, check=True)
+        namespace = {}
+        exec(completed.stdout, {}, namespace)
+        if not namespace['_mlstatus']:
+            # _mlstatus is set by the TMod4 Python bindings
+            if msg is None:
+                msg = 'modules system command failed: '
+                if isinstance(completed.args, str):
+                    msg += completed.args
+                else:
+                    msg += ' '.join(completed.args)
+
+            raise EnvironError(msg)
+
+
 class LModImpl(TModImpl):
     """Module system for Lmod (Tcl/Lua)."""
 
@@ -570,6 +611,8 @@ def init_modules_system(modules_kind=None):
         _modules_system = ModulesSystem(NoModImpl())
     elif modules_kind == 'tmod':
         _modules_system = ModulesSystem(TModImpl())
+    elif modules_kind == 'tmod4':
+        _modules_system = ModulesSystem(TMod4Impl())
     elif modules_kind == 'lmod':
         _modules_system = ModulesSystem(LModImpl())
     else:
diff --git a/unittests/test_modules.py b/unittests/test_modules.py
index 7cd2608bee..e0587d19eb 100644
--- a/unittests/test_modules.py
+++ b/unittests/test_modules.py
@@ -116,6 +116,22 @@ def expected_unload_instr(self, module):
         return 'module unload %s' % module
 
 
+class TestTMod4ModulesSystem(_TestModulesSystem):
+    def setUp(self):
+        try:
+            modules.init_modules_system('tmod4')
+        except ConfigError:
+            self.skipTest('tmod4 not supported')
+        else:
+            super().setUp()
+
+    def expected_load_instr(self, module):
+        return 'module load %s' % module
+
+    def expected_unload_instr(self, module):
+        return 'module unload %s' % module
+
+
 class TestLModModulesSystem(_TestModulesSystem):
     def setUp(self):
         try: