diff --git a/README.md b/README.md
index 09926b0..a5d6289 100644
--- a/README.md
+++ b/README.md
@@ -83,10 +83,23 @@ organization:
     },
 ]
 ```
-all specified `old` registries will be replaced by `new` in all manifests yaml
-files for that organization. Replacement happen during pushing manifests into
-application registry.
+All specified `old` registries will be replaced by `new` in all manifests yaml
+files for that organization.
 
+You can pattern match and replace registry strings with the regexp field instead
+of matching whole strings.  Both `old` and `new` will be evalutated as regexes
+when `regexp` is set to `True`.  If `regexp` is missing it defaults to `False`.
+Here's an example:
+```
+"replace_registry": [
+    {
+        "old": "quay.io$",
+        "new": "example.com",
+        "regexp": "True",
+    },
+]
+```
+Replacements occur when pushing manifests into the application registry.
 
 ### Greenwave integration
 
diff --git a/example.test.env.yaml b/example.test.env.yaml
index 6e0427b..26bd395 100644
--- a/example.test.env.yaml
+++ b/example.test.env.yaml
@@ -42,6 +42,7 @@ private_org:
 replace_registry:
   - old: registry.stage.redhat.io
     new: registry.redhat.io
+    regex: ""
 # Config of the instance tested to check if Greenwave policies are met for the
 # NVR
 greenwave:
diff --git a/omps/quay.py b/omps/quay.py
index 5903023..999ca0f 100644
--- a/omps/quay.py
+++ b/omps/quay.py
@@ -257,9 +257,18 @@ def replace_registries(self, text):
             return text
 
         for conf in self._replace_registry_conf:
-            old = conf['old']
             new = conf['new']
-            if old in text:
+            old = conf['old']
+            regexp = False
+
+            if 'regexp' in conf.keys():
+                regexp = conf['regexp']
+
+            if regexp:
+                if re.search(old, text, flags=re.MULTILINE):
+                    self.logger.info("Replacing registries with regexp '%s'", regexp)
+                    text = re.sub(old, new, text, flags=re.MULTILINE)
+            elif old in text:
                 self.logger.info("Replacing registry '%s' with '%s'", old, new)
                 text = text.replace(old, new)
 
diff --git a/tests/api/test_common.py b/tests/api/test_common.py
index d0e5619..4beb0bb 100644
--- a/tests/api/test_common.py
+++ b/tests/api/test_common.py
@@ -22,7 +22,7 @@ def _yield_yaml_files(dir_path):
     old = 'quay.io'
     new = 'example.com'
     qo = QuayOrganization('testorg', 'random token', replace_registry_conf=[
-        {'old': old, 'new': new}
+        {'old': old, 'new': new, 'regexp': ""}
     ])
 
     should_be_replaced = set()
diff --git a/tests/integration/replace_registry/replace_registry_test.py b/tests/integration/replace_registry/replace_registry_test.py
index 5a7dfc8..3e9506d 100644
--- a/tests/integration/replace_registry/replace_registry_test.py
+++ b/tests/integration/replace_registry/replace_registry_test.py
@@ -41,7 +41,7 @@ def koji_registries(replace_conf, path):
         the manifest at 'path'
 
         Args:
-            replace_conf: List of {'old': ..., 'new': ...} dictionaries.
+            replace_conf: List of {'old': ..., 'new': ..., 'regexp': ...} dictionaries.
             path: Path of the manifest.
 
         Returns:
diff --git a/tests/test_quay.py b/tests/test_quay.py
index 3c9fd24..d3abfe5 100644
--- a/tests/test_quay.py
+++ b/tests/test_quay.py
@@ -483,6 +483,19 @@ def test_replace_registries_unconfigured(self):
         assert res == text
         assert id(res) == id(text)
 
+    @pytest.mark.parametrize('text,expected', [
+        (
+            'Registry reg_old will be replaced using a regexp: reg_old',
+            'Registry reg_old will be replaced using a regexp: reg_new',
+        )
+    ])
+    def test_regexp_replace_registries(self, text, expected):
+        """Test if registries are replaced properly with regexp"""
+        replace_conf = [{'old': 'reg_old$', 'new': 'reg_new', 'regexp': 'True'}]
+        org = 'testorg'
+        qo = QuayOrganization(org, TOKEN, replace_registry_conf=replace_conf)
+        assert qo.replace_registries(text) == expected
+
 
 class TestOrgManager:
     """Tets for OrgManager class"""
diff --git a/tests/test_settings.py b/tests/test_settings.py
index 946011d..b8e480e 100644
--- a/tests/test_settings.py
+++ b/tests/test_settings.py
@@ -130,6 +130,29 @@ class ConfClass(DefaultConfig):
     assert conf.organizations == expected
 
 
+def test_organziation_regexp():
+    """Organziation with regexp Test"""
+    expected = {
+        'myorg': {
+            'public': False,
+            'oauth_token': 'token',
+            'replace_registry': [
+                {
+                    'old': 'quay.io/$',
+                    'new': 'example.com',
+                    'regexp': 'True',
+                },
+            ]
+        }
+    }
+
+    class ConfClass(DefaultConfig):
+        ORGANIZATIONS = expected
+
+    conf = Config(ConfClass)
+    assert conf.organizations == expected
+
+
 @pytest.mark.parametrize('conf', [
     {
         'organization': None
@@ -161,6 +184,12 @@ class ConfClass(DefaultConfig):
                 {'old': 'expected new too'}
             ]
         }
+    }, {
+        'organization': {
+            'replace_registry': [
+                {'regexp': 'False'}
+            ]
+        }
     }
 
 ])