diff --git a/integration/vite-css-test.ts b/integration/vite-css-test.ts
index 863025c5c4..e02a95aafd 100644
--- a/integration/vite-css-test.ts
+++ b/integration/vite-css-test.ts
@@ -551,6 +551,10 @@ async function hmrWorkflow({
         file: "styles-bundled.css",
         selector: "#css-bundled",
       },
+      {
+        file: "styles.module.css",
+        selector: "#css-modules",
+      },
       {
         file: "styles-postcss-linked.css",
         selector: "#css-postcss-linked",
@@ -564,10 +568,6 @@ async function hmrWorkflow({
       ...(routeBase === "rsc-server-first-route"
         ? []
         : ([
-            {
-              file: "styles.module.css",
-              selector: "#css-modules",
-            },
             {
               file: "styles-vanilla-local.css.ts",
               selector: "#css-vanilla-local",
diff --git a/packages/react-router-dev/vite/rsc/plugin.ts b/packages/react-router-dev/vite/rsc/plugin.ts
index bdb90486cc..24a953c2c0 100644
--- a/packages/react-router-dev/vite/rsc/plugin.ts
+++ b/packages/react-router-dev/vite/rsc/plugin.ts
@@ -280,9 +280,19 @@ export function reactRouterRSCVitePlugin(): Vite.PluginOption[] {
       async hotUpdate(this, { server, file, modules }) {
         if (this.environment.name !== "rsc") return;
 
+        const clientModules =
+          server.environments.client.moduleGraph.getModulesByFile(file);
+
+        const vite = await import("vite");
         const isServerOnlyChange =
-          (server.environments.client.moduleGraph.getModulesByFile(file)
-            ?.size ?? 0) === 0;
+          !clientModules ||
+          clientModules.size === 0 ||
+          // Handle CSS injected from server-first routes (with ?direct query
+          // string) since the client graph has a reference to the CSS
+          (vite.isCSSRequest(file) &&
+            Array.from(clientModules).some((mod) =>
+              mod.id?.includes("?direct"),
+            ));
 
         for (const mod of getModulesWithImporters(modules)) {
           if (!mod.file) continue;