diff --git a/packages/commonjs/src/transform-commonjs.js b/packages/commonjs/src/transform-commonjs.js
index fd0fe0a9d..c530f38c2 100644
--- a/packages/commonjs/src/transform-commonjs.js
+++ b/packages/commonjs/src/transform-commonjs.js
@@ -292,6 +292,14 @@ export default async function transformCommonjs(
         case 'Identifier': {
           const { name } = node;
           if (!isReference(node, parent) || scope.contains(name)) return;
+          const isClassBodyPropertyKey =
+            parent.type === 'PropertyDefinition' && parent.key === node;
+          if (isClassBodyPropertyKey && parent.value) return;
+          const prependLeftToClassBodyPropertyKey = (value) => {
+            if (isClassBodyPropertyKey && !parent.value) {
+              magicString.prependLeft(node.start, value);
+            }
+          };
           switch (name) {
             case 'require':
               uses.require = true;
@@ -305,6 +313,7 @@ export default async function transformCommonjs(
                   skippedNodes.add(parent.value);
                   magicString.prependRight(node.start, 'require: ');
                 }
+                prependLeftToClassBodyPropertyKey('require = ');
                 replacedDynamicRequires.push(node);
               }
               return;
@@ -316,10 +325,12 @@ export default async function transformCommonjs(
             case 'global':
               uses.global = true;
               if (!ignoreGlobal) {
+                prependLeftToClassBodyPropertyKey('global = ');
                 replacedGlobal.push(node);
               }
               return;
             case 'define':
+              prependLeftToClassBodyPropertyKey('define = ');
               magicString.overwrite(node.start, node.end, 'undefined', {
                 storeName: true
               });
diff --git a/packages/commonjs/test/fixtures/function/class-body-property-keys-are-special-keywords/_config.js b/packages/commonjs/test/fixtures/function/class-body-property-keys-are-special-keywords/_config.js
new file mode 100644
index 000000000..bca2bd171
--- /dev/null
+++ b/packages/commonjs/test/fixtures/function/class-body-property-keys-are-special-keywords/_config.js
@@ -0,0 +1,3 @@
+module.exports = {
+  description: 'preserve the class body property keys even if they are special keywords',
+};
diff --git a/packages/commonjs/test/fixtures/function/class-body-property-keys-are-special-keywords/main.js b/packages/commonjs/test/fixtures/function/class-body-property-keys-are-special-keywords/main.js
new file mode 100644
index 000000000..67ac52d62
--- /dev/null
+++ b/packages/commonjs/test/fixtures/function/class-body-property-keys-are-special-keywords/main.js
@@ -0,0 +1,7 @@
+class Rollup {
+  define;
+  require;
+  global;
+}
+
+exports.Rollup = Rollup;
diff --git a/packages/commonjs/test/snapshots/function.js.md b/packages/commonjs/test/snapshots/function.js.md
index bffef3a99..f6259d9f6 100644
--- a/packages/commonjs/test/snapshots/function.js.md
+++ b/packages/commonjs/test/snapshots/function.js.md
@@ -241,6 +241,36 @@ Generated by [AVA](https://avajs.dev).
       `,
     }
 
+## class-body-property-keys-are-special-keywords
+
+> Snapshot 1
+
+    {
+      'main.js': `'use strict';␊
+      ␊
+      Object.defineProperty(exports, '__esModule', { value: true });␊
+      ␊
+      var commonjsGlobal = typeof globalThis !== 'undefined' ? globalThis : typeof window !== 'undefined' ? window : typeof global !== 'undefined' ? global : typeof self !== 'undefined' ? self : {};␊
+      ␊
+      function commonjsRequire(path) {␊
+      	throw new Error('Could not dynamically require "' + path + '". Please configure the dynamicRequireTargets or/and ignoreDynamicRequires option of @rollup/plugin-commonjs appropriately for this require call to work.');␊
+      }␊
+      ␊
+      var main = {};␊
+      ␊
+      class Rollup {␊
+        define = undefined;␊
+        require = commonjsRequire;␊
+        global = commonjsGlobal;␊
+      }␊
+      ␊
+      var Rollup_1 = main.Rollup = Rollup;␊
+      ␊
+      exports.Rollup = Rollup_1;␊
+      exports.default = main;␊
+      `,
+    }
+
 ## compiled-esm-default-is-module-exports-false
 
 > Snapshot 1
diff --git a/packages/commonjs/test/snapshots/function.js.snap b/packages/commonjs/test/snapshots/function.js.snap
index 1d0e1a45e..7ea311e07 100644
Binary files a/packages/commonjs/test/snapshots/function.js.snap and b/packages/commonjs/test/snapshots/function.js.snap differ