diff --git a/CMakeLists.txt b/CMakeLists.txt
index cd226232cfca2..e6af6274dd623 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -556,8 +556,7 @@ if(runtime_cxxmodules)
     set(modules_idx_cmd COMMAND ${CMAKE_COMMAND} -E env PATH="${library_output_dir}\\\;%PATH%"
                                 ROOTIGNOREPREFIX=1 ROOT_HIST=0 $<TARGET_FILE:root.exe> -l -q -b)
   else()
-    set(modules_idx_cmd COMMAND ${ld_library_path}=${library_output_dir}:$ENV{${ld_library_path}}
-                                ROOT_INCLUDE_PATH=${DEFAULT_ROOT_INCLUDE_PATH}
+    set(modules_idx_cmd COMMAND ROOT_INCLUDE_PATH=${DEFAULT_ROOT_INCLUDE_PATH}
                                 ROOTIGNOREPREFIX=1 ROOT_HIST=0 $<TARGET_FILE:root.exe> -l -q -b)
   endif()
   add_custom_command(OUTPUT ${library_output_dir}/modules.idx
@@ -582,7 +581,7 @@ if(WIN32)
                           ROOT_INCLUDE_PATH=${DEFAULT_ROOT_INCLUDE_PATH}
                           ROOTIGNOREPREFIX=1 ROOT_HIST=0 $<TARGET_FILE:root.exe> -l -q -b -n -x ${CMAKE_SOURCE_DIR}/tutorials/hsimple.C -e return)
 else()
-  set(hsimple_cmd COMMAND ROOT_INCLUDE_PATH=${DEFAULT_ROOT_INCLUDE_PATH} ${ld_library_path}=${CMAKE_LIBRARY_OUTPUT_DIRECTORY}:$ENV{${ld_library_path}}
+  set(hsimple_cmd COMMAND ROOT_INCLUDE_PATH=${DEFAULT_ROOT_INCLUDE_PATH}
                           ROOTIGNOREPREFIX=1 ROOT_HIST=0 $<TARGET_FILE:root.exe> -l -q -b -n -x ${CMAKE_SOURCE_DIR}/tutorials/hsimple.C -e return)
 endif()
 add_custom_command(OUTPUT tutorials/hsimple.root
diff --git a/bindings/tpython/test/CMakeLists.txt b/bindings/tpython/test/CMakeLists.txt
index e2d313f7d4986..f56b36306cfa5 100644
--- a/bindings/tpython/test/CMakeLists.txt
+++ b/bindings/tpython/test/CMakeLists.txt
@@ -14,8 +14,6 @@ if(MSVC)
       PYTHONPATH=${ROOTSYS}/bin;$ENV{PYTHONPATH})
 else()
   set(tpython_gtest_env
-      PATH=${ROOTSYS}/bin:$ENV{PATH}
-      LD_LIBRARY_PATH=${ROOTSYS}/lib:$ENV{LD_LIBRARY_PATH}
       PYTHONPATH=${ROOTSYS}/lib:$ENV{PYTHONPATH})
 endif()
 
diff --git a/cmake/modules/RootMacros.cmake b/cmake/modules/RootMacros.cmake
index 6c2f8f7a6bd6f..d06a0fcb6440c 100644
--- a/cmake/modules/RootMacros.cmake
+++ b/cmake/modules/RootMacros.cmake
@@ -1884,7 +1884,6 @@ function(ROOT_ADD_PYUNITTESTS name)
   else()
     set(ROOT_ENV
         PATH=${ROOTSYS}/bin:$ENV{PATH}
-        ${ld_library_path}=${ROOTSYS}/lib:$ENV{${ld_library_path}}
         PYTHONPATH=${ROOTSYS}/lib:$ENV{PYTHONPATH})
   endif()
   string(REGEX REPLACE "[_]" "-" good_name "${name}")
@@ -1910,7 +1909,6 @@ function(ROOT_ADD_PYUNITTEST name file)
   else()
     set(ROOT_ENV
         PATH=${ROOTSYS}/bin:$ENV{PATH}
-        ${ld_library_path}=${ROOTSYS}/lib:$ENV{${ld_library_path}}
         PYTHONPATH=${ROOTSYS}/lib:$ENV{PYTHONPATH})
   endif()
   string(REGEX REPLACE "[_]" "-" good_name "${name}")
@@ -3130,15 +3128,13 @@ function(ROOTTEST_ADD_TEST testname)
   else()
     string(REPLACE ";" ":" _path "${ROOTTEST_ENV_PATH}")
     string(REPLACE ";" ":" _pythonpath "${ROOTTEST_ENV_PYTHONPATH}")
-    string(REPLACE ";" ":" _librarypath "${ROOTTEST_ENV_LIBRARYPATH}")
 
 
     set(environment ENVIRONMENT
                     ${ROOTTEST_ENV_EXTRA}
                     ${ARG_ENVIRONMENT}
                     PATH=${_path}:$ENV{PATH}
-                    PYTHONPATH=${_pythonpath}:$ENV{PYTHONPATH}
-                    ${ld_library_path}=${_librarypath}:$ENV{${ld_library_path}})
+                    PYTHONPATH=${_pythonpath}:$ENV{PYTHONPATH})
   endif()
 
   if(ARG_WORKING_DIR)
@@ -3383,15 +3379,13 @@ function(ROOTTEST_ADD_UNITTEST_DIR)
   else()
     string(REPLACE ";" ":" _path "${ROOTTEST_ENV_PATH}")
     string(REPLACE ";" ":" _pythonpath "${ROOTTEST_ENV_PYTHONPATH}")
-    string(REPLACE ";" ":" _librarypath "${ROOTTEST_ENV_LIBRARYPATH}")
 
 
     set(environment ENVIRONMENT
                     ${ROOTTEST_ENV_EXTRA}
                     ${ARG_ENVIRONMENT}
                     PATH=${_path}:$ENV{PATH}
-                    PYTHONPATH=${_pythonpath}:$ENV{PYTHONPATH}
-                    ${ld_library_path}=${_librarypath}:$ENV{${ld_library_path}})
+                    PYTHONPATH=${_pythonpath}:$ENV{PYTHONPATH})
   endif()
 
   ROOT_ADD_TEST(${fulltestname} COMMAND ${binary}
diff --git a/hist/hbook/CMakeLists.txt b/hist/hbook/CMakeLists.txt
index 3a34254435f2e..75ca4b0b2c2b9 100644
--- a/hist/hbook/CMakeLists.txt
+++ b/hist/hbook/CMakeLists.txt
@@ -31,3 +31,17 @@ ROOT_STANDARD_LIBRARY_PACKAGE(Hbook
     TreePlayer
     RIO
 )
+
+# This is needed in particular for macOS, where the path of the GNU Fortran
+# library might not be in the default DYLD_LIBRARY_PATH, but it gets picked
+# up with enable_language(Fortran).
+if(APPLE AND CMAKE_Fortran_COMPILER_ID STREQUAL "GNU")
+  # Compute path to quadmath
+  execute_process(
+    COMMAND ${CMAKE_Fortran_COMPILER} -print-file-name=libgfortran.dylib
+    OUTPUT_VARIABLE LIBGFORTRAN_PATH
+    OUTPUT_STRIP_TRAILING_WHITESPACE)
+  get_filename_component(LIBGFORTRAN_DIR "${LIBGFORTRAN_PATH}" DIRECTORY)
+  set_property(TARGET Hbook APPEND PROPERTY BUILD_RPATH "${LIBGFORTRAN_DIR}")
+  set_property(TARGET Hbook APPEND PROPERTY INSTALL_RPATH "${LIBGFORTRAN_DIR}")
+endif()
diff --git a/main/CMakeLists.txt b/main/CMakeLists.txt
index 0a35172a60050..98e50fd87e853 100644
--- a/main/CMakeLists.txt
+++ b/main/CMakeLists.txt
@@ -55,6 +55,20 @@ if(fortran AND CMAKE_Fortran_COMPILER)
   ROOT_EXECUTABLE(g2root g2root.f LIBRARIES minicern CMAKENOEXPORT)
   set_target_properties(g2root PROPERTIES COMPILE_FLAGS "-w")
   ROOT_EXECUTABLE(h2root h2root.cxx LIBRARIES Core RIO Net Hist Graf Graf3d Gpad Tree Matrix MathCore Thread minicern CMAKENOEXPORT)
+
+  # This is needed in particular for macOS, where the path of the GNU Fortran
+  # library might not be in the default DYLD_LIBRARY_PATH, but it gets picked
+  # up with enable_language(Fortran).
+  if(APPLE AND CMAKE_Fortran_COMPILER_ID STREQUAL "GNU")
+    # Compute path to quadmath
+    execute_process(
+      COMMAND ${CMAKE_Fortran_COMPILER} -print-file-name=libgfortran.dylib
+      OUTPUT_VARIABLE LIBGFORTRAN_PATH
+      OUTPUT_STRIP_TRAILING_WHITESPACE)
+    get_filename_component(LIBGFORTRAN_DIR "${LIBGFORTRAN_PATH}" DIRECTORY)
+    set_property(TARGET h2root APPEND PROPERTY BUILD_RPATH "${LIBGFORTRAN_DIR}")
+    set_property(TARGET h2root APPEND PROPERTY INSTALL_RPATH "${LIBGFORTRAN_DIR}")
+  endif()
 endif()
 
 file(GLOB utils RELATIVE ${CMAKE_CURRENT_SOURCE_DIR} python/root*)
diff --git a/roottest/CMakeLists.txt b/roottest/CMakeLists.txt
index 4f009fef75cf9..2ce0eda3549b0 100644
--- a/roottest/CMakeLists.txt
+++ b/roottest/CMakeLists.txt
@@ -230,25 +230,8 @@ if(MSVC)
 else()
   set(ROOTTEST_ENV_PYTHONPATH ${ROOT_LIBRARY_DIR})
 endif()
-set(ROOTTEST_ENV_LIBRARYPATH ${ROOT_LIBRARY_DIR})
 set(ROOTTEST_ENV_EXTRA)
 
-# Optionally, add Fortran link directories. This is needed in particular for
-# macOS, where the path of the Fortran library might not be in the default
-# DYLD_LIBRARY_PATH, but it gets picked up with enable_language(Fortran).
-if(APPLE AND fortran)
-  # Convert Fortran link dirs to colon-separated string
-  string(REPLACE ";" ":" FORTRAN_LINK_PATH "${CMAKE_Fortran_IMPLICIT_LINK_DIRECTORIES}")
-
-  # Append to ROOTTEST_ENV_LIBRARYPATH
-  set(ROOTTEST_ENV_LIBRARYPATH "${ROOTTEST_ENV_LIBRARYPATH}:${FORTRAN_LINK_PATH}")
-
-  # Deduplicate ROOTTEST_ENV_LIBRARYPATH
-  string(REPLACE ":" ";" _tmp "${ROOTTEST_ENV_LIBRARYPATH}")
-  list(REMOVE_DUPLICATES _tmp)
-  string(REPLACE ";" ":" ROOTTEST_ENV_LIBRARYPATH "${_tmp}")
-endif()
-
 if(MSVC)
   set(ROOTTEST_ENVIRONMENT
       PYTHONPATH=${ROOTTEST_ENV_PYTHONPATH})
@@ -257,8 +240,7 @@ else()
   string(REGEX REPLACE ":$" "" TESTPYTHONPATH "${ROOTTEST_ENV_PYTHONPATH}:$ENV{PYTHONPATH}")
   set(ROOTTEST_ENVIRONMENT
       PATH=${ROOTTEST_ENV_PATH}:$ENV{PATH}
-      PYTHONPATH=${TESTPYTHONPATH}
-      ${ld_library_path}=${ROOTTEST_ENV_LIBRARYPATH}:$ENV{${ld_library_path}})
+      PYTHONPATH=${TESTPYTHONPATH})
   if (gnuinstall)
     set(ROOTTEST_ENVIRONMENT ${ROOTTEST_ENVIRONMENT} ROOTIGNOREPREFIX=1)
   endif()
diff --git a/roottest/root/ntuple/makeproject/rntuple/CMakeLists.txt b/roottest/root/ntuple/makeproject/rntuple/CMakeLists.txt
index 6350493a69afc..f5c14200eb2e0 100644
--- a/roottest/root/ntuple/makeproject/rntuple/CMakeLists.txt
+++ b/roottest/root/ntuple/makeproject/rntuple/CMakeLists.txt
@@ -53,17 +53,8 @@ target_link_directories(read_rntuple PRIVATE ${CMAKE_CURRENT_BINARY_DIR}/librntu
 
 # Need to also explicitly set the LD_LIBRARY_PATH (at least on MacOS), so that
 # the generated library with the custom class can be loaded by the read test.
-# Setting the value of ${ld_library_path} in the ENVIRONMENT argument of the
-# ROOTTEST_ADD_TEST function will not work, because that function sets the same
-# variable internally, thus overriding our choice. The simplest thing to do is
-# to append our directory to the ${ROOTTEST_ENV_LIBRARYPATH} contents, which
-# are automatically used by ROOTTEST_ADD_TEST
-set(_roottest_env_librarypath ${ROOTTEST_ENV_LIBRARYPATH})
-set(ROOTTEST_ENV_LIBRARYPATH "${ROOTTEST_ENV_LIBRARYPATH}:${CMAKE_CURRENT_BINARY_DIR}/librntuplestltest")
 ROOTTEST_ADD_TEST(read_rntuple
                   EXEC ./read_rntuple
                   FIXTURES_REQUIRED read_rntuple_executable
                   # PATH is used on Windows to find libraries for loading
-                  ENVIRONMENT PATH=${CMAKE_CURRENT_BINARY_DIR}/librntuplestltest)
-set(ROOTTEST_ENV_LIBRARYPATH ${_roottest_env_librarypath})
-
+                  ENVIRONMENT ${ld_library_path}=${CMAKE_CURRENT_BINARY_DIR}/librntuplestltest)
diff --git a/roottest/root/ntuple/makeproject/ttree/CMakeLists.txt b/roottest/root/ntuple/makeproject/ttree/CMakeLists.txt
index afe03634fd858..4787ee6e526a7 100644
--- a/roottest/root/ntuple/makeproject/ttree/CMakeLists.txt
+++ b/roottest/root/ntuple/makeproject/ttree/CMakeLists.txt
@@ -54,16 +54,8 @@ target_link_directories(read_ttree PRIVATE ${CMAKE_CURRENT_BINARY_DIR}/libttrees
 
 # Need to also explicitly set the LD_LIBRARY_PATH (at least on MacOS), so that
 # the generated library with the custom class can be loaded by the read test.
-# Setting the value of ${ld_library_path} in the ENVIRONMENT argument of the
-# ROOTTEST_ADD_TEST function will not work, because that function sets the same
-# variable internally, thus overriding our choice. The simplest thing to do is
-# to append our directory to the ${ROOTTEST_ENV_LIBRARYPATH} contents, which
-# are automatically used by ROOTTEST_ADD_TEST
-set(_roottest_env_librarypath ${ROOTTEST_ENV_LIBRARYPATH})
-set(ROOTTEST_ENV_LIBRARYPATH "${ROOTTEST_ENV_LIBRARYPATH}:${CMAKE_CURRENT_BINARY_DIR}/libttreestltest")
 ROOTTEST_ADD_TEST(read_ttree
                   EXEC ./read_ttree
-		              FIXTURES_REQUIRED makeproject_read_ttree_executable
+                  FIXTURES_REQUIRED makeproject_read_ttree_executable
                   # PATH is used on Windows to find libraries for loading
-                  ENVIRONMENT PATH=${CMAKE_CURRENT_BINARY_DIR}/libttreestltest)
-set(ROOTTEST_ENV_LIBRARYPATH ${_roottest_env_librarypath})
+                  ENVIRONMENT ${ld_library_path}=${CMAKE_CURRENT_BINARY_DIR}/libttreestltest)
diff --git a/tutorials/CMakeLists.txt b/tutorials/CMakeLists.txt
index 0a8ea310234bd..4320a5104be84 100644
--- a/tutorials/CMakeLists.txt
+++ b/tutorials/CMakeLists.txt
@@ -18,7 +18,6 @@ if(DEFINED ROOT_SOURCE_DIR)  # Testing using the binary tree
   set(ROOT_root_CMD root.exe)
   if(NOT MSVC)  # Ignore environment on Windows
     set(ROOT_environ PATH=${CMAKE_BINARY_DIR}/bin:$ENV{PATH}
-                     ${ld_library_path}=${CMAKE_BINARY_DIR}/lib:$ENV{${ld_library_path}}
                      ROOT_INCLUDE_PATH=${CMAKE_BINARY_DIR}/tutorials/io/tree:${DEFAULT_ROOT_INCLUDE_PATH}
                      PYTHONPATH=${CMAKE_BINARY_DIR}/lib:$ENV{PYTHONPATH})
   else()