diff --git a/iseq.c b/iseq.c
index 096d456f1146b2..2d83bc3f06e879 100644
--- a/iseq.c
+++ b/iseq.c
@@ -359,8 +359,12 @@ rb_iseq_mark(const rb_iseq_t *iseq)
                     rb_gc_mark_movable((VALUE)ci);
                 }
                 if (cc && vm_cc_markable(cc)) {
-                    rb_gc_mark_movable((VALUE)cc);
-                    // TODO: check enable
+                    if (!vm_cc_invalidated_p(cc)) {
+                        rb_gc_mark_movable((VALUE)cc);
+                    }
+                    else {
+                        cds[i].cc = rb_vm_empty_cc();
+                    }
                 }
             }
         }
diff --git a/vm_callinfo.h b/vm_callinfo.h
index 4ee6fa72e6ffe3..1fe76eb9023103 100644
--- a/vm_callinfo.h
+++ b/vm_callinfo.h
@@ -357,6 +357,17 @@ vm_cc_markable(const struct rb_callcache *cc)
     return FL_TEST_RAW((VALUE)cc, VM_CALLCACHE_UNMARKABLE) == 0;
 }
 
+static inline bool
+vm_cc_invalidated_p(const struct rb_callcache *cc)
+{
+    if (cc->klass && METHOD_ENTRY_INVALIDATED(vm_cc_cme(cc))) {
+        return false;
+    }
+    else {
+        return true;
+    }
+}
+
 // For MJIT. cc_cme is supposed to have inlined `vm_cc_cme(cc)`.
 static inline bool
 vm_cc_valid_p(const struct rb_callcache *cc, const rb_callable_method_entry_t *cc_cme, VALUE klass)