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CellNOpt (matlab)

CellNetOptimizer (CellNOpt, also known as CNO) was originaly a matlab toolbox for creating logic-based models of signal transduction networks, and training them against high-throughput biochemical data using various logic formalisms. The development of CellNOpt is now mostly around R verssion (see, but you can download the MATLAB version in this repository.

Q2LM: Quering Quantitative Logic Models

Q1LM is a MATLAB library that uses constrained fuzzy logic models based on prior knowledge networks to address two questions about a biological system: (i) What perturbation results in a specified downstream effect?; (ii) In waht environments do thos perturbations produce that effect?.

Q2LM is a tool developed by Melody Morris and Doug Lauffenburger. © Copyright 2011,2012 Massachusetts Institute of Technology.


  • For the CellNOpt MATLAB toolbox: M. K. Morris, I. Melas, J. Saez-Rodriguez. Construction of cell type-specific logic models of signaling networks using CellNetOptimizer. to appear in Methods in Molecular Biology:Computational Toxicology, Ed. B. Reisfeld and A. Mayeno, Humana Press. Preprint

  • For the Q2LM toolbox: M. K. Morris, Z. Shriver, R. Sasisekharan, D. A. Lauffenburger. 2012. Querying quantitative logic models (Q2LM) to study intracellular signaling networks and cell-cytokine interactions. Biotech. J. 7.

CellNOpt and Q2LM are free software: you can redistribute them and/or modify it under the terms of the GNU General Public License version 2 as published by the Free Software Foundation. Q2LM is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License at for more details


MATLAB version of CellNOpt






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