Target 1 2 3 4 5 6 7 8 9 10 11 \ 1 5c2h 3uri 1u1b 1g2k 3pww 3nw9 4cig 5a7b 4x6p 4cra 3ivg 4agq 2 3uri 3ag9 4cra 4gid 3uri 1g2k 2p4y 3gnw 3bv9 1eby 2vkm 3arq 3 4rfm 5dwr 4ogj 3myg 4qd6 4gr0 1bzc 3e5a 3ivg 4cra 3b1m 2qbq 4 4ty7 4crc 4cra 3gnw 3jvs 2p4y 1g2k 2vw5 3utu 1z95 3b68 2qbp 5 4agq 3uri 3utu 2yge 1u1b 3p5o 2qnq 3b1m 1k1i 4cig 3zso 2qbp 6 5dwr 2qbq 5c2h 5dwr 1nvq 4k18 3uri 2p4y 3prs 3b1m 4cra 3utu 7 4twp 2fvd 3p5o 4twp 4x6p 1yc1 1h23 4w9h 3gnw 3qgy 3g0w 1h22 8 3u8n 3uri 3ag9 1u1b 4cig 3gnw 3zso 3oe4 2p4y 1g2k 3ivg 1eby 9 3o9i 1g2k 2p4y 3pww 3o9i 4cig 3zso 3b1m 4cra 4tmn 3uri 1e66 10 3p5o 3uri 3b1m 3ag9 4cig 1h23 3arq 4gr0 2p4y 4gid 3prs 4cra 11 3ejr 3utu 1u1b 3jvs 3uo4 3ag9 4e5w 3b1m 4w9l 2fxs 4k18 3uri 12 3ebp 3ag9 1u1b 3b1m 1h22 4w9l 3nw9 3uri 3zso 3gnw 3arq 3wz8 13 2vvn 2p4y 3gnw 3ag9 1u1b 3nw9 3ozs 2yge 1h22 4gr0 4x6p 3oe4 14 3arp 3ag9 3uri 4gr0 3tsk 4gid 2vkm 3gnw 3utu 1h23 1mq6 1g2k 15 3gnw 3ag9 3uri 3utu 3prs 2qbp 2p4y 3gnw 4cra 1u1b 3zso 4gr0 16 1e66 3ag9 3uri 1u1b 3utu 3tsk 3gnw 3b1m 4cra 1mq6 3b68 3zso 17 3f3e 3ag9 3zso 2yge 3utu 5dwr 2vw5 1g2k 1u1b 2p4y 4cig 3gnw 18 2cet 3ag9 2x00 3zso 3uri 4gr0 5dwr 4w9l 4gid 2p4y 3p5o 3rlr 19 4gid 4gid 3utu 4tmn 3o9i 3ag9 2x00 2p4y 3gnw 3uri 1g2k 3b1m 20 4pcs 3uri 1u1b 3utu 1h23 3ag9 3b1m 4ogj 3gnw 1yc1 1mq6 4tmn 21 3ge7 3ag9 1z6e 3uri 2qbp 3ge7 1u1b 4k18 3prs 3ebp 3zso 2p4y 22 3e93 3e93 3utu 3ag9 2p4y 3b1m 1g2k 3zso 4gid 3uri 3tsk 3prs 23 3qqs 3ag9 3uri 2p4y 1u1b 2qbp 3b1m 3utu 1h23 2qbr 3zso 2qbq 24 2r9w 1bzc 2p4y 3b1m 3arq 3ag9 1u1b 3jvs 4cra 3uri 2yki 3tsk 25 2qbp 2qbp 2qbr 2qbq 2p4y 3b1m 3ag9 2x00 3arq 4x6p 4cig 3jvs 26 3ag9 3ag9 4cra 2p4y 4gid 3gnw 3uri 1mq6 3utu 3ivg 4cig 3tsk 27 4tmn 3up2 3uo4 3nw9 3myg 3utu 1pxn 3o9i 4ogj 1mq6 4rfm 2brb 28 3coy 3uri 3ag9 1u1b 2p4y 3gnw 3tsk 3nw9 4crc 3zso 3b1m 3utu 29 2fvd 3ag9 3b1m 2p4y 1z6e 2qbp 4cra 3uri 1lpg 1u1b 3nw9 3up2 30 4ivc 3zso 4cra 3ge7 3nw9 3ozs 4ivc 3b1m 1u1b 3g0w 4cig 3utu 31 4jia 3utu 2p4y 1mq6 3ag9 3wz8 2wtv 3nw9 3tsk 2br1 2qbq 1u1b 32 1nvq 1nvq 3ag9 3gnw 3zso 1g2k 3arq 1u1b 3wz8 3jvs 3b1m 3zsx 33 2zcq 1u1b 3nw9 3uri 3gnw 3utu 5dwr 3ag9 4gr0 2yge 2qbr 3myg 34 3utu 3utu 4cra 3b1m 4gid 3uri 3ag9 3zso 1mq6 3e93 3jvs 3gnw 35 2p4y 2p4y 3b1m 3zso 3ag9 3gnw 2vw5 4cra 3uri 3pww 5dwr 2yge 36 3myg 2p4y 3b1m 1u1b 3arq 3oe4 3ag9 3zso 3utu 1nvq 4cra 1mq6 37 1sqa 3b1m 2p4y 4cra 3arq 3p5o 4dld 1h23 3ivg 1eby 5c2h 5dwr 38 3dd0 1u1b 3gnw 3arq 2qbp 2p4y 4gr0 3oe5 3zso 3utu 3ag9 1mq6 39 2yki 2p4y 3b1m 3uri 3ag9 2yki 2qbr 1u1b 3tsk 1mq6 4gr0 3zso 40 3g0w 3zso 3b1m 3g0w 5dwr 2c3i 3p5o 3prs 3b68 2qbq 1z95 3gnw 41 2al5 3ag9 3utu 3uri 2yge 1u1b 3zso 3gnw 3zsx 2vw5 3b1m 2p4y 42 4de1 3b1m 3ag9 3arq 4eo8 1z95 3prs 1u1b 3fur 4k18 3e5a 3up2 43 3fv1 3ag9 1u1b 3uri 3gnw 1g2k 3zso 1eby 3b1m 2qbp 3jvs 2yge 44 2p15 2p15 3gnw 2p4y 3utu 1g2k 5dwr 1h22 4cra 3b1m 3uri 3ag9 45 1mq6 3b1m 3gnw 1mq6 4cra 2xbv 2qbp 1z6e 3uri 3ag9 2p4y 4crc 46 4f3c 1y6r 4f2w 2fxs 4f3c 3b5r 1yc1 3ejr 3b68 3oe4 1h22 1nc3 47 1o3f 2p4y 3gnw 3k5v 3arq 3jvs 4cra 3ag9 1bzc 2p15 3utu 1z95 48 2vw5 3uri 2p4y 2qbp 3ag9 3bv9 2qbr 3zso 2vw5 1h22 4tmn 2wtv 49 3kr8 3nw9 4twp 1u1b 1h22 3jya 1z95 3arq 4k18 3ag9 4hge 3utu 50 2x00 3ag9 3uri 3utu 4gr0 3gnw 4x6p 3zso 4crc 1z6e 1u1b 2vkm 51 3nw9 3nw9 3ag9 4gr0 3uri 4rfm 3e5a 1u1b 2p4y 4cra 3gnw 3zsx 52 3zso 3b1m 3zsx 1h22 3ag9 3zso 2p4y 3ozs 1u1b 3arq 2r9w 3gnw 53 2xb8 1u1b 2qbp 3arq 2xb8 2qbr 3utu 3ag9 3ozs 2qbq 3uri 3gnw 54 4w9h 3ag9 4w9l 3o9i 3uri 3gnw 3tsk 3utu 2r9w 4gr0 3e5a 3fur 55 3uex 3fur 2zb1 3k5v 2p4y 3jvs 3b1m 4crc 4k18 3e92 3ag9 4agp 56 4gr0 4gr0 2x00 3b1m 2xbv 3tsk 3uri 1g2k 2qbq 3arq 3zso 2r9w 57 1u1b 1u1b 3b1m 3ag9 2p4y 2qbp 3zso 3uri 4gr0 3wz8 2p15 3coy 12 13 14 15 16 17 18 19 20 21 22 23 \ 1 1mq6 2p4y 3jvs 1z6e 3b1m 3utu 4w9i 4gr0 3ozs 4crc 5tmn 3b5r 2 3utu 3prs 2qbp 5dwr 1mq6 4tmn 3b1m 2wtv 4twp 2qbq 3tsk 1u1b 3 2p4y 1nvq 2v7a 5c2h 4w9l 3gnw 3tsk 2qbp 3prs 2qbr 4rfm 2zb1 4 3ozt 2wtv 2fxs 3zso 2yge 2x00 2p15 3up2 4cig 1u1b 3b65 1z6e 5 1z6e 3bv9 2vw5 4eo8 2xbv 5dwr 2x00 3zsx 3tsk 2xb8 2wer 4mgd 6 2wtv 1u1b 2zb1 3rlr 4gid 1z6e 1g2k 2qbp 1y6r 2fvd 3arq 2qbr 7 3arq 1bzc 4ivb 1qkt 2fxs 1u1b 4hge 3zso 3b68 3up2 1y6r 5dwr 8 3utu 2yge 4gr0 2zcq 3tsk 1h23 5tmn 3ozs 4dld 2vkm 3b1m 3nw9 9 5c2h 1mq6 2x00 3ag9 2qnq 3fur 3b68 2p15 1h23 3prs 3utu 3myg 10 3utu 5dwr 4crc 1u1b 2qbp 4w9l 1g2k 2vkm 2x00 3e93 4f9w 1h22 11 3oe4 5tmn 3arq 4rfm 3ozs 4jia 2yge 4ivd 3k5v 5a7b 3gnw 4gid 12 3prs 4cig 3zsx 1mq6 5dwr 4tmn 1h23 3utu 3e93 1k1i 3oe4 3tsk 13 3oe5 4crc 1g2k 1z6e 2yki 3utu 3zsx 2yfe 1y6r 4cra 2qbp 3ivg 14 3zso 4w9l 1eby 1lpg 3prs 3o9i 2x00 3bv9 1u1b 4rfm 1h22 3e93 15 3b1m 1lpg 4gid 1z6e 3nw9 3e93 3tsk 4crc 1mq6 2xbv 3jvs 3o9i 16 3prs 1h22 3arq 3nw9 2yge 2yki 3oe4 2qbq 2qbp 2p4y 1nvq 1g2k 17 1z95 3uri 3g0w 3b1m 3prs 3ozs 2qbp 3nw9 3p5o 2x00 2qnq 3arq 18 2qbp 4eo8 4w9c 4w9h 3ejr 1u1b 3utu 2fxs 3prs 3qgy 4crc 4x6p 19 2vkm 3prs 1mq6 3pww 1eby 3p5o 2qbq 3zso 2qnq 3b68 2xbv 3uo4 20 4gr0 1z6e 3zso 3arq 3prs 1g2k 2fxs 4w9c 4cig 2qbr 3jvs 2p4y 21 1nvq 2yki 3utu 1mq6 5dwr 2fxs 3arq 4gid 1h23 4ivd 1eby 3g0w 22 3e92 3gnw 2zb1 2vkm 1eby 1u1b 3bv9 4gr0 4crc 2wtv 2xbv 2qbp 23 1mq6 3gnw 3arq 4cig 1k1i 4w9l 1bzc 2zcr 2fxs 4gr0 4tmn 2zy1 24 4gr0 3up2 1z6e 1g2k 2fxs 2vkm 4ty7 2qbp 4gid 2x00 4crc 3e5a 25 3utu 3b68 1h22 1u1b 4crc 2zb1 3zsx 4j3l 1h23 4tmn 1z95 4ty7 26 3zso 3wz8 2p15 4crc 3b1m 3prs 2vkm 3arp 2qbq 4w9i 3arq 3o9i 27 3e5a 4twp 3oe4 1nvq 4eor 3arq 2wtv 2fxs 3ozt 2fvd 4tmn 2xb8 28 3arq 1eby 1z6e 2qbp 1mq6 4gid 4gr0 4qd6 4cra 1h23 4w9l 4ogj 29 2qbr 3jvs 5dwr 4gid 1mq6 3utu 3zso 3e93 3gnw 3qgy 2p15 3ebp 30 2p4y 4ivd 3gnw 1z95 1g2k 2yge 3b68 4hge 3bv9 5dwr 1yc1 3jvs 31 2qbr 4ogj 3prs 1nvq 3uo4 3b1m 3zsx 4gr0 4jia 3arq 3zso 3gnw 32 2p4y 1mq6 1z95 2qbp 3uri 2qe4 4k18 5dwr 3nw9 2vkm 2yge 4crc 33 3tsk 2vw5 3arq 3zso 1mq6 3b1m 4gid 2qbp 5c2h 3prs 1h23 3o9i 34 2p4y 1lpg 3tsk 3prs 2p15 3bv9 4qd6 1z6e 2qbp 5dwr 1h23 4crc 35 3arq 1mq6 1g2k 2x00 1h22 4cig 1u1b 4k18 3utu 3jvs 3fur 3prs 36 1eby 4cig 4gr0 1g2k 2vkm 3gnw 2x00 3nw9 1z6e 1h23 2xbv 3ozs 37 3o9i 2wtv 1z95 4eo8 3g0w 3utu 2fxs 1z6e 2qbq 4tmn 4cig 2p15 38 1a30 4cig 1h22 3ozs 3oe4 2qbr 3coy 4dld 2yge 3nw9 1vso 4crc 39 3gnw 2qbq 4cra 3utu 3prs 2wtv 1eby 4gid 3nw9 1z6e 3uo4 2xbv 40 4f9w 3b5r 1g2k 4cra 3ag9 4mgd 1y6r 2p4y 4djv 3rlr 2wtv 3utu 41 1h22 5dwr 1k1i 3b68 1z95 3arq 2r9w 2qnq 3oe4 4tmn 1g2k 2xb8 42 2qbp 2p4y 5dwr 2yge 2r9w 3nw9 1h22 2fvd 1g2k 2qbq 2xb8 4gr0 43 2vw5 2p4y 2qbq 5dwr 2qbr 3nw9 2x00 3b65 5tmn 3o9i 4gid 4dld 44 2vw5 2wtv 3arp 3p5o 3zso 1h23 3zsx 2qbp 3nw9 1u1b 2yki 3jvs 45 1u1b 3zso 3utu 4gr0 2p15 1h23 3oe4 1eby 1lpg 3e93 3prs 2qbq 46 1u1b 3prs 4x6p 3nw9 2r9w 3g0w 3arq 3b1m 2p4y 3gnw 2qe4 2wn9 47 3fur 1mq6 3b1m 2vw5 4crc 3ivg 3zso 3zsx 4rfm 3oe4 2wtv 3up2 48 4e5w 2yge 1z6e 3utu 1h23 4cra 3gnw 5dwr 1eby 4qd6 3ozs 1u1b 49 5dwr 4cra 3jvs 2qbp 3b1m 3fur 3ivg 3tsk 4crc 2yki 4de3 1h23 50 4cra 4gid 3nw9 2p4y 2qbp 3tsk 3e93 3bv9 2xbv 3b1m 3prs 4w9l 51 4ogj 3zso 4eor 4w9l 5dwr 3wz8 3arq 3utu 3b1m 2qbp 3oe4 1k1i 52 4cra 3jvs 4qd6 3tsk 1h23 2x00 4tmn 3ivg 3nw9 3utu 3ozt 3e5a 53 3ozt 1h23 5dwr 3up2 3g0w 3oe5 2p4y 3zso 1a30 3nw9 3jvs 2r9w 54 1u1b 2x00 3bv9 1h22 1mq6 4rfm 4cig 3jvs 1h23 3zso 3oe5 2fxs 55 3zsx 1qkt 4gr0 4ea2 4cra 4cig 1z95 3utu 2fxs 2p15 1g2k 2c3i 56 3utu 4k18 1bzc 4cra 2fxs 4w9i 3ag9 3gnw 3fur 4de1 2qbp 3jvs 57 3gnw 4cra 3arp 3nw9 4gid 2vkm 4tmn 3jvs 3utu 3coz 3fur 4qd6 24 25 26 27 28 29 1 3prs 3zso 2xbv 2qbp 4w9h 2r9w 2 4crc 3nw9 4wiv 3o9i 2qbr 3zso 3 2fvd 4twp 3qgy 4k18 1mq6 3arq 4 2fvd 5dwr 3wz8 3k5v 3b1m 1h22 5 1lpg 3up2 3ivg 3gnw 3arq 4de3 6 3k5v 4crc 2c3i 3o9i 1mq6 2yki 7 2p4y 3ivg 1pxn 2vw5 4de3 2qbp 8 1h22 4m0z 3e5a 2r9w 3ozt 3bv9 9 2yge 3bv9 1u1b 2qbp 5dwr 1eby 10 3gnw 3zso 1mq6 1z6e 3jvs 2qbr 11 4ivc 4gr0 1k1i 2br1 2qbp 3rlr 12 2qbp 3fur 3pww 2qbr 4ea2 4eo8 13 3fur 1mq6 5dwr 3e5a 3arq 4ty7 14 3pww 2yge 2p4y 4crc 1z6e 4x6p 15 4w9i 3e5a 1eby 3pww 5c2h 3fur 16 3fur 3pww 3arp 1h23 4crc 3oe5 17 4ty7 2vkm 1k1i 3pww 4hge 4w9l 18 4m0y 3oe4 3b1m 3e5a 3b68 3oe5 19 4cra 5dwr 1u1b 1h23 4w9l 1h22 20 1lpg 3b68 2xbv 2r9w 3tsk 1eby 21 4rfm 4w9l 3b68 3b1m 1bzc 3nw9 22 4w9l 4x6p 3jvs 4cra 1mq6 4rfm 23 3jvs 3zsx 1z6e 2fvd 1h22 1g2k 24 2qbq 3utu 3fur 2qbr 3qgy 2wer 25 3uri 1mq6 5dwr 1z6e 1g2k 3zso 26 2r9w 5c2h 1g2k 1u1b 4tmn 5dwr 27 1u1b 2xii 4k18 1g2k 3prs 3ui7 28 2qbr 4x6p 4cig 3oe4 5dwr 3prs 29 2fvd 2qbq 2yge 4ogj 3prs 1g2k 30 2br1 3uri 3ag9 2fxs 3b5r 4ivb 31 3up2 2qbp 4cig 1z6e 3bv9 5dwr 32 4ogj 1k1i 1z6e 3utu 1y6r 3arv 33 4qd6 2p4y 3ivg 3bv9 3up2 1z6e 34 2qbr 2zda 1g2k 4rfm 4ogj 1eby 35 1z6e 3ivg 2r9w 1k1i 3zsx 3wz8 36 3jvs 3wz8 3bgz 4crc 4wiv 3up2 37 3b5r 3zso 4qd6 2qbr 3nw9 3myg 38 3jvs 2fxs 2r9w 5tmn 2wer 4gkm 39 2qbp 1g2k 3wz8 2vkm 3arq 3fur 40 2vw5 4eo8 3oe4 3wz8 3zsx 2qbp 41 1bzc 2vkm 2qbp 3n76 3up2 4cig 42 3jvs 3gnw 4ogj 4cra 3uri 2x00 43 3up2 3zsx 3b68 1h22 1z95 4ogj 44 5c2h 2qbq 3b68 2yge 1mq6 4cig 45 4cig 3bv9 2qbr 3jvs 2v7a 3arq 46 3coz 1mq6 2iwx 3nx7 1h23 4de3 47 1h23 4cig 3uri 3g0w 5c2h 2qbr 48 4crc 3tsk 3arq 2qbq 2fxs 3b1m 49 5c2h 3rr4 3zso 4dli 3qgy 3ozt 50 4ty7 1h22 3pww 1lpg 1mq6 2qbq 51 1bzc 3coy 3prs 3myg 3fur 3oe5 52 3uri 4cig 1mq6 1eby 2yge 2qbr 53 2xii 3pww 3b1m 1eby 4dld 2fvd 54 3e92 4crc 2zcq 3nw9 3zsx 3ivg 55 1u1b 5tmn 3arq 4de3 2fvd 1ydt 56 3prs 2zy1 3arv 4crc 1qkt 1u1b 57 4cig 1eby 4x6p 1h22 1h23 3ivg Summary of the forward screening power: ========================================================= Average enrichment factor among top 1% = 8.11 Average enrichment factor among top 5% = 3.36 Average enrichment factor among top 10% = 2.31 The best ligand is found among top 1% candidates for 15 cluster(s); success rate = 26.3% The best ligand is found among top 5% candidates for 24 cluster(s); success rate = 42.1% The best ligand is found among top 10% candidates for 28 cluster(s); success rate = 49.1% ================================================================================================ Template command for running the bootstrap in R program========================================= rm(list=ls()); require(boot); data_all<-read.table("GenScore_Top1.results",header=TRUE); data<-as.matrix(data_all[,2]); mymean<-function(x,indices) sum(x[indices])/57; data.boot<-boot(aa,mymean,R=10000,stype="i",sim="ordinary"); sink("GenScore_Top1-ci.results"); a<-boot.ci(data.boot,conf=0.9,type=c("bca")); print(a); sink(); ===============================================================================================