diff --git a/compiler/src/dotty/tools/dotc/typer/Inliner.scala b/compiler/src/dotty/tools/dotc/typer/Inliner.scala
index c1e3222892d6..0444b5b6a9f6 100644
--- a/compiler/src/dotty/tools/dotc/typer/Inliner.scala
+++ b/compiler/src/dotty/tools/dotc/typer/Inliner.scala
@@ -1239,17 +1239,60 @@ class Inliner(call: tpd.Tree, rhsToInline: tpd.Tree)(implicit ctx: Context) {
     assert(level == 0)
     val inlinedFrom = enclosingInlineds.last
     val ctx1 = tastyreflect.MacroExpansion.context(inlinedFrom)
-    val evaluatedSplice = Splicer.splice(body, inlinedFrom.sourcePos, MacroClassLoader.fromContext)(ctx1)
 
-    val inlinedNormailizer = new TreeMap {
-      override def transform(tree: tpd.Tree)(implicit ctx: Context): tpd.Tree = tree match {
-        case Inlined(EmptyTree, Nil, expr) if enclosingInlineds.isEmpty => transform(expr)
-        case _ => super.transform(tree)
+    val dependencies = macroDependencies(body)
+
+    if (dependencies.nonEmpty) {
+      var location = inlinedFrom.symbol
+      if (location.isLocalDummy) location = location.owner
+
+      val msg =
+        em"""Failed to expand macro. This macro depends on an implementation that is defined in the same project and not yet compiled.
+           |In particular ${inlinedFrom.symbol} depends on ${dependencies.map(_.show).mkString(", ")}.
+           |
+           |Moving ${dependencies.map(_.show).mkString(", ")} to a different project would fix this.
+           |""".stripMargin
+      ctx.error(msg, inlinedFrom.sourcePos)
+      EmptyTree
+    } else {
+      val evaluatedSplice = Splicer.splice(body, inlinedFrom.sourcePos, MacroClassLoader.fromContext)(ctx1)
+
+      val inlinedNormailizer = new TreeMap {
+        override def transform(tree: tpd.Tree)(implicit ctx: Context): tpd.Tree = tree match {
+          case Inlined(EmptyTree, Nil, expr) if enclosingInlineds.isEmpty => transform(expr)
+          case _ => super.transform(tree)
+        }
       }
+      val normalizedSplice = inlinedNormailizer.transform(evaluatedSplice)
+      if (normalizedSplice.isEmpty) normalizedSplice
+      else normalizedSplice.withSpan(span)
     }
-    val normalizedSplice = inlinedNormailizer.transform(evaluatedSplice)
-    if (normalizedSplice.isEmpty) normalizedSplice
-    else normalizedSplice.withSpan(span)
+  }
+
+  /** Return the set of symbols that are refered at level -1 by the tree and defined in the current run.
+   *  This corresponds to the symbols that will need to be interpreted.
+   */
+  private def macroDependencies(tree: Tree)(implicit ctx: Context) = {
+    new TreeAccumulator[Set[Symbol]] {
+      private[this] var level = -1
+      override def apply(syms: Set[Symbol], tree: tpd.Tree)(implicit ctx: Context): Set[Symbol] = {
+        if (level != -1) foldOver(syms, tree)
+        else tree match {
+          case tree: RefTree if level == -1 && tree.symbol.isDefinedInCurrentRun && !tree.symbol.isLocal =>
+            foldOver(syms + tree.symbol, tree)
+          case Quoted(body) =>
+            level += 1
+            try apply(syms, body)
+            finally level -= 1
+          case Spliced(body) =>
+            level -= 1
+            try apply(syms, body)
+            finally level += 1
+          case _ =>
+            foldOver(syms, tree)
+        }
+      }
+    }.apply(Set.empty, tree)
   }
 }
 
diff --git a/tests/neg-macros/macros-in-same-project-1.check b/tests/neg-macros/macros-in-same-project-1.check
new file mode 100644
index 000000000000..f257aa16f0d2
--- /dev/null
+++ b/tests/neg-macros/macros-in-same-project-1.check
@@ -0,0 +1,8 @@
+-- Error: tests/neg-macros/macros-in-same-project-1/Bar.scala:2:13 -----------------------------------------------------
+2 |  Foo.myMacro() // error
+  |  ^^^^^^^^^^^^^
+  |Failed to expand macro. This macro depends on an implementation that is defined in the same project and not yet compiled.
+  |In particular method myMacro depends on method aMacroImplementation.
+  |
+  |Moving method aMacroImplementation to a different project would fix this.
+  | This location is in code that was inlined at Bar.scala:2
diff --git a/tests/neg-macros/macros-in-same-project-1/Bar.scala b/tests/neg-macros/macros-in-same-project-1/Bar.scala
new file mode 100644
index 000000000000..2924e2b2411a
--- /dev/null
+++ b/tests/neg-macros/macros-in-same-project-1/Bar.scala
@@ -0,0 +1,3 @@
+object Bar {
+  Foo.myMacro() // error
+}
diff --git a/tests/neg-macros/macros-in-same-project-1/Foo.scala b/tests/neg-macros/macros-in-same-project-1/Foo.scala
new file mode 100644
index 000000000000..0bc30057b4fe
--- /dev/null
+++ b/tests/neg-macros/macros-in-same-project-1/Foo.scala
@@ -0,0 +1,9 @@
+import scala.quoted._
+
+object Foo {
+
+  inline def myMacro(): Unit = ${ aMacroImplementation }
+
+  def aMacroImplementation given QuoteContext: Expr[Unit] = '{ println("Hello") }
+
+}
diff --git a/tests/neg-macros/macros-in-same-project-2.check b/tests/neg-macros/macros-in-same-project-2.check
new file mode 100644
index 000000000000..0ee5ec3f3a98
--- /dev/null
+++ b/tests/neg-macros/macros-in-same-project-2.check
@@ -0,0 +1,8 @@
+-- Error: tests/neg-macros/macros-in-same-project-2/Bar.scala:5:9 ------------------------------------------------------
+5 |  myMacro() // error
+  |  ^^^^^^^^^
+  |Failed to expand macro. This macro depends on an implementation that is defined in the same project and not yet compiled.
+  |In particular method myMacro depends on method aMacroImplementation, object Foo.
+  |
+  |Moving method aMacroImplementation, object Foo to a different project would fix this.
+  | This location is in code that was inlined at Bar.scala:5
diff --git a/tests/neg-macros/macros-in-same-project-2/Bar.scala b/tests/neg-macros/macros-in-same-project-2/Bar.scala
new file mode 100644
index 000000000000..ebd6fb25895f
--- /dev/null
+++ b/tests/neg-macros/macros-in-same-project-2/Bar.scala
@@ -0,0 +1,7 @@
+object Bar {
+
+  inline def myMacro(): Unit = ${ Foo.aMacroImplementation }
+
+  myMacro() // error
+
+}
diff --git a/tests/neg-macros/macros-in-same-project-2/Foo.scala b/tests/neg-macros/macros-in-same-project-2/Foo.scala
new file mode 100644
index 000000000000..f4a4a63f72cf
--- /dev/null
+++ b/tests/neg-macros/macros-in-same-project-2/Foo.scala
@@ -0,0 +1,7 @@
+import scala.quoted._
+
+object Foo {
+
+  def aMacroImplementation given QuoteContext: Expr[Unit] = '{ println("Hello") }
+
+}
diff --git a/tests/neg-macros/macros-in-same-project-3.check b/tests/neg-macros/macros-in-same-project-3.check
new file mode 100644
index 000000000000..e2865e55578d
--- /dev/null
+++ b/tests/neg-macros/macros-in-same-project-3.check
@@ -0,0 +1,8 @@
+-- Error: tests/neg-macros/macros-in-same-project-3/Baz.scala:2:13 -----------------------------------------------------
+2 |  Bar.myMacro() // error
+  |  ^^^^^^^^^^^^^
+  |Failed to expand macro. This macro depends on an implementation that is defined in the same project and not yet compiled.
+  |In particular method myMacro depends on method aMacroImplementation.
+  |
+  |Moving method aMacroImplementation to a different project would fix this.
+  | This location is in code that was inlined at Baz.scala:2
diff --git a/tests/neg-macros/macros-in-same-project-3/Bar.scala b/tests/neg-macros/macros-in-same-project-3/Bar.scala
new file mode 100644
index 000000000000..1cf2a2fa40e4
--- /dev/null
+++ b/tests/neg-macros/macros-in-same-project-3/Bar.scala
@@ -0,0 +1,9 @@
+import scala.quoted._
+
+object Bar {
+
+  inline def myMacro(): Unit = ${ aMacroImplementation }
+
+  def aMacroImplementation given QuoteContext: Expr[Unit] = Foo.hello()
+
+}
diff --git a/tests/neg-macros/macros-in-same-project-3/Baz.scala b/tests/neg-macros/macros-in-same-project-3/Baz.scala
new file mode 100644
index 000000000000..fa9ced2b6930
--- /dev/null
+++ b/tests/neg-macros/macros-in-same-project-3/Baz.scala
@@ -0,0 +1,3 @@
+object Baz {
+  Bar.myMacro() // error
+}
diff --git a/tests/neg-macros/macros-in-same-project-3/Foo.scala b/tests/neg-macros/macros-in-same-project-3/Foo.scala
new file mode 100644
index 000000000000..ab5e99c0df41
--- /dev/null
+++ b/tests/neg-macros/macros-in-same-project-3/Foo.scala
@@ -0,0 +1,7 @@
+import scala.quoted._
+
+object Foo {
+
+  def hello() given QuoteContext: Expr[Unit] = '{ println("Hello") }
+
+}
diff --git a/tests/neg-macros/macros-in-same-project-4.check b/tests/neg-macros/macros-in-same-project-4.check
new file mode 100644
index 000000000000..5cdc12b31cb9
--- /dev/null
+++ b/tests/neg-macros/macros-in-same-project-4.check
@@ -0,0 +1,8 @@
+-- Error: tests/neg-macros/macros-in-same-project-4/Bar.scala:5:13 -----------------------------------------------------
+5 |  Foo.myMacro() // error
+  |  ^^^^^^^^^^^^^
+  |Failed to expand macro. This macro depends on an implementation that is defined in the same project and not yet compiled.
+  |In particular method myMacro depends on method aMacroImplementation.
+  |
+  |Moving method aMacroImplementation to a different project would fix this.
+  | This location is in code that was inlined at Bar.scala:5
diff --git a/tests/neg-macros/macros-in-same-project-4/Bar.scala b/tests/neg-macros/macros-in-same-project-4/Bar.scala
new file mode 100644
index 000000000000..5a17499ffea7
--- /dev/null
+++ b/tests/neg-macros/macros-in-same-project-4/Bar.scala
@@ -0,0 +1,8 @@
+import scala.quoted._
+
+object Bar {
+
+  Foo.myMacro() // error
+
+  def hello() given QuoteContext: Expr[Unit] = '{ println("Hello") }
+}
diff --git a/tests/neg-macros/macros-in-same-project-4/Foo.scala b/tests/neg-macros/macros-in-same-project-4/Foo.scala
new file mode 100644
index 000000000000..b880850afdcb
--- /dev/null
+++ b/tests/neg-macros/macros-in-same-project-4/Foo.scala
@@ -0,0 +1,9 @@
+import scala.quoted._
+
+object Foo {
+
+  inline def myMacro(): Unit = ${ aMacroImplementation }
+
+  def aMacroImplementation given QuoteContext: Expr[Unit] = Bar.hello()
+
+}