diff --git a/CHANGELOG.unreleased.md b/CHANGELOG.unreleased.md
index 0efdabeaf8e..4cac1cf1fc4 100644
--- a/CHANGELOG.unreleased.md
+++ b/CHANGELOG.unreleased.md
@@ -15,6 +15,7 @@ For upgrade instructions, please check the [migration guide](MIGRATIONS.released
 - Added support for reading uint24 rgb layers in datasets with zarr2/zarr3/n5/neuroglancerPrecomputed format, as used for voxelytics predictions. [#7413](https://github.com/scalableminds/webknossos/pull/7413)
 - Adding a remote dataset can now be done by providing a Neuroglancer URI. [#7416](https://github.com/scalableminds/webknossos/pull/7416)
 - Added a filter to the Task List->Stats column to quickly filter for tasks with "Prending", "In-Progress" or "Finished" instances. [#7430](https://github.com/scalableminds/webknossos/pull/7430)
+- Added support for S3-compliant object storage services (e.g. MinIO) as a storage backend for remote datasets. [#7453](https://github.com/scalableminds/webknossos/pull/7453)
 
 ### Changed
 - An appropriate error is returned when requesting an API version that is higher that the current version. [#7424](https://github.com/scalableminds/webknossos/pull/7424)
diff --git a/webknossos-datastore/app/com/scalableminds/webknossos/datastore/datavault/S3DataVault.scala b/webknossos-datastore/app/com/scalableminds/webknossos/datastore/datavault/S3DataVault.scala
index 5f0b84f5870..957ff8f4bd7 100644
--- a/webknossos-datastore/app/com/scalableminds/webknossos/datastore/datavault/S3DataVault.scala
+++ b/webknossos-datastore/app/com/scalableminds/webknossos/datastore/datavault/S3DataVault.scala
@@ -8,9 +8,11 @@ import com.amazonaws.auth.{
   BasicAWSCredentials,
   EnvironmentVariableCredentialsProvider
 }
+import com.amazonaws.client.builder.AwsClientBuilder.EndpointConfiguration
 import com.amazonaws.regions.Regions
 import com.amazonaws.services.s3.{AmazonS3, AmazonS3ClientBuilder}
 import com.amazonaws.services.s3.model.{GetObjectRequest, S3Object}
+import com.amazonaws.util.AwsHostNameUtils
 import com.scalableminds.util.tools.Fox
 import com.scalableminds.webknossos.datastore.storage.{RemoteSourceDescriptor, S3AccessKeyCredential}
 import net.liftweb.common.{Box, Failure, Full}
@@ -27,8 +29,8 @@ class S3DataVault(s3AccessKeyCredential: Option[S3AccessKeyCredential], uri: URI
     case None        => throw new Exception(s"Could not parse S3 bucket for ${uri.toString}")
   }
 
-  val client: AmazonS3 =
-    S3DataVault.getAmazonS3Client(s3AccessKeyCredential)
+  private lazy val client: AmazonS3 =
+    S3DataVault.getAmazonS3Client(s3AccessKeyCredential, uri)
 
   private def getRangeRequest(bucketName: String, key: String, range: NumericRange[Long]): GetObjectRequest =
     new GetObjectRequest(bucketName, key).withRange(range.start, range.end)
@@ -117,7 +119,8 @@ object S3DataVault {
 
   // https://s3.region-code.amazonaws.com/bucket-name/key-name
   private def isPathStyle(uri: URI): Boolean =
-    uri.getHost.matches("s3(.[\\w\\-_]+)?.amazonaws.com")
+    uri.getHost.matches("s3(.[\\w\\-_]+)?.amazonaws.com") ||
+      (!uri.getHost.contains("amazonaws.com") && uri.getHost.contains("."))
 
   // S3://bucket-name/key-name
   private def isShortStyle(uri: URI): Boolean =
@@ -143,12 +146,25 @@ object S3DataVault {
         new AnonymousAWSCredentialsProvider
     }
 
-  private def getAmazonS3Client(credentialOpt: Option[S3AccessKeyCredential]): AmazonS3 =
-    AmazonS3ClientBuilder.standard
+  private def isNonAmazonHost(uri: URI): Boolean =
+    isPathStyle(uri) && !uri.getHost.endsWith(".amazonaws.com")
+
+  private def getAmazonS3Client(credentialOpt: Option[S3AccessKeyCredential], uri: URI): AmazonS3 = {
+    val basic = AmazonS3ClientBuilder.standard
       .withCredentials(getCredentialsProvider(credentialOpt))
-      .withRegion(Regions.DEFAULT_REGION)
       .withForceGlobalBucketAccessEnabled(true)
-      .build
+    if (isNonAmazonHost(uri))
+      basic
+        .withPathStyleAccessEnabled(true)
+        .withEndpointConfiguration(
+          new EndpointConfiguration(
+            s"http://${uri.getAuthority}",
+            AwsHostNameUtils.parseRegion(uri.getAuthority, "s3")
+          )
+        )
+        .build()
+    else basic.withRegion(Regions.DEFAULT_REGION).build()
+  }
 
 }