diff --git a/jenkins-pipelines/manager/centos-manager-backup-200gb.jenkinsfile b/jenkins-pipelines/manager/centos-manager-backup-200gb.jenkinsfile
index 160ad9716f..16af532582 100644
--- a/jenkins-pipelines/manager/centos-manager-backup-200gb.jenkinsfile
+++ b/jenkins-pipelines/manager/centos-manager-backup-200gb.jenkinsfile
@@ -5,9 +5,9 @@ def lib = library identifier: 'sct@snapshot', retriever: legacySCM(scm)
 
 managerPipeline(
     backend: 'aws',
-    region: '''["us-east-1", "us-west-2"]''',
+    region: 'us-west-2',
     test_name: 'mgmt_cli_test.MgmtCliTest.test_backup_feature',
-    test_config: '''["test-cases/manager/manager-regression-multiDC-set-distro.yaml", "configurations/manager/200gb_dataset.yaml"]''',
+    test_config: '''["test-cases/manager/manager-regression-singleDC-set-distro.yaml", "configurations/manager/200gb_dataset.yaml"]''',
 
     post_behavior_db_nodes: 'destroy',
     post_behavior_loader_nodes: 'destroy',
diff --git a/jenkins-pipelines/manager/centos-manager-backup.jenkinsfile b/jenkins-pipelines/manager/centos-manager-backup.jenkinsfile
index 2a85e38688..d246c91584 100644
--- a/jenkins-pipelines/manager/centos-manager-backup.jenkinsfile
+++ b/jenkins-pipelines/manager/centos-manager-backup.jenkinsfile
@@ -5,9 +5,9 @@ def lib = library identifier: 'sct@snapshot', retriever: legacySCM(scm)
 
 managerPipeline(
     backend: 'aws',
-    region: '''["us-east-1", "us-west-2"]''',
+    region: 'us-west-2',
     test_name: 'mgmt_cli_test.MgmtCliTest.test_backup_feature',
-    test_config: 'test-cases/manager/manager-regression-multiDC-set-distro.yaml',
+    test_config: 'test-cases/manager/manager-regression-singleDC-set-distro.yaml',
 
     post_behavior_db_nodes: 'destroy',
     post_behavior_loader_nodes: 'destroy',
diff --git a/jenkins-pipelines/manager/centos-manager-sanity.jenkinsfile b/jenkins-pipelines/manager/centos-manager-sanity.jenkinsfile
index 18854bb1f8..68f61e827e 100644
--- a/jenkins-pipelines/manager/centos-manager-sanity.jenkinsfile
+++ b/jenkins-pipelines/manager/centos-manager-sanity.jenkinsfile
@@ -5,9 +5,9 @@ def lib = library identifier: 'sct@snapshot', retriever: legacySCM(scm)
 
 managerPipeline(
     backend: 'aws',
-    region: '''["us-east-1", "us-west-2"]''',
+    region: 'us-west-2',
     test_name: 'mgmt_cli_test.MgmtCliTest.test_manager_sanity',
-    test_config: 'test-cases/manager/manager-regression-multiDC-set-distro.yaml',
+    test_config: 'test-cases/manager/manager-regression-singleDC-set-distro.yaml',
 
     post_behavior_db_nodes: 'destroy',
     post_behavior_loader_nodes: 'destroy',
diff --git a/jenkins-pipelines/manager/debian10-manager-sanity.jenkinsfile b/jenkins-pipelines/manager/debian10-manager-sanity.jenkinsfile
index a8090b9a7e..db29f920ae 100644
--- a/jenkins-pipelines/manager/debian10-manager-sanity.jenkinsfile
+++ b/jenkins-pipelines/manager/debian10-manager-sanity.jenkinsfile
@@ -5,9 +5,9 @@ def lib = library identifier: 'sct@snapshot', retriever: legacySCM(scm)
 
 managerPipeline(
     backend: 'aws',
-    region: '''["us-east-1", "us-west-2"]''',
+    region: 'us-west-2',
     test_name: 'mgmt_cli_test.MgmtCliTest.test_manager_sanity',
-    test_config: '''["test-cases/manager/manager-regression-multiDC-set-distro.yaml", "configurations/manager/debian10.yaml"]''',
+    test_config: '''["test-cases/manager/manager-regression-singleDC-set-distro.yaml", "configurations/manager/debian10.yaml"]''',
 
     post_behavior_db_nodes: 'destroy',
     post_behavior_loader_nodes: 'destroy',
diff --git a/jenkins-pipelines/manager/debian11-manager-sanity.jenkinsfile b/jenkins-pipelines/manager/debian11-manager-sanity.jenkinsfile
index 56013aa230..7156b5a6b7 100644
--- a/jenkins-pipelines/manager/debian11-manager-sanity.jenkinsfile
+++ b/jenkins-pipelines/manager/debian11-manager-sanity.jenkinsfile
@@ -5,9 +5,9 @@ def lib = library identifier: 'sct@snapshot', retriever: legacySCM(scm)
 
 managerPipeline(
     backend: 'aws',
-    region: '''["us-east-1", "us-west-2"]''',
+    region: 'us-west-2',
     test_name: 'mgmt_cli_test.MgmtCliTest.test_manager_sanity',
-    test_config: '''["test-cases/manager/manager-regression-multiDC-set-distro.yaml", "configurations/manager/debian11.yaml"]''',
+    test_config: '''["test-cases/manager/manager-regression-singleDC-set-distro.yaml", "configurations/manager/debian11.yaml"]''',
 
     post_behavior_db_nodes: 'destroy',
     post_behavior_loader_nodes: 'destroy',
diff --git a/jenkins-pipelines/manager/manager-sanity.jenkinsfile b/jenkins-pipelines/manager/manager-sanity.jenkinsfile
index f8c2795c76..c4d3c6d9dd 100644
--- a/jenkins-pipelines/manager/manager-sanity.jenkinsfile
+++ b/jenkins-pipelines/manager/manager-sanity.jenkinsfile
@@ -5,9 +5,9 @@ def lib = library identifier: 'sct@snapshot', retriever: legacySCM(scm)
 
 managerPipeline(
     backend: 'aws',
-    region: '''["us-east-1", "us-west-2"]''',
+    region: 'us-east-1',
     test_name: 'mgmt_cli_test.MgmtCliTest.test_manager_sanity',
-    test_config: 'test-cases/manager/manager-regression-multiDC-set-distro.yaml',
+    test_config: 'test-cases/manager/manager-regression-singleDC-set-distro.yaml',
 
     timeout: [time: 500, unit: 'MINUTES'],
     post_behavior_db_nodes: 'destroy',
diff --git a/jenkins-pipelines/manager/ubuntu20-manager-sanity.jenkinsfile b/jenkins-pipelines/manager/ubuntu20-manager-sanity.jenkinsfile
index 86c40ca313..bc48512092 100644
--- a/jenkins-pipelines/manager/ubuntu20-manager-sanity.jenkinsfile
+++ b/jenkins-pipelines/manager/ubuntu20-manager-sanity.jenkinsfile
@@ -5,9 +5,9 @@ def lib = library identifier: 'sct@snapshot', retriever: legacySCM(scm)
 
 managerPipeline(
     backend: 'aws',
-    region: '''["us-east-1", "us-west-2"]''',
+    region: 'us-east-1',
     test_name: 'mgmt_cli_test.MgmtCliTest.test_manager_sanity',
-    test_config: '''["test-cases/manager/manager-regression-multiDC-set-distro.yaml", "configurations/manager/ubuntu20.yaml"]''',
+    test_config: '''["test-cases/manager/manager-regression-singleDC-set-distro.yaml", "configurations/manager/ubuntu20.yaml"]''',
 
     post_behavior_db_nodes: 'destroy',
     post_behavior_loader_nodes: 'destroy',
diff --git a/jenkins-pipelines/manager/ubuntu22-manager-sanity.jenkinsfile b/jenkins-pipelines/manager/ubuntu22-manager-sanity.jenkinsfile
index 35c30b0c17..9b035933de 100644
--- a/jenkins-pipelines/manager/ubuntu22-manager-sanity.jenkinsfile
+++ b/jenkins-pipelines/manager/ubuntu22-manager-sanity.jenkinsfile
@@ -5,9 +5,9 @@ def lib = library identifier: 'sct@snapshot', retriever: legacySCM(scm)
 
 managerPipeline(
     backend: 'aws',
-    region: '''["us-east-1", "us-west-2"]''',
+    region: 'us-east-1',
     test_name: 'mgmt_cli_test.MgmtCliTest.test_manager_sanity',
-    test_config: 'test-cases/manager/manager-regression-multiDC-set-distro.yaml',
+    test_config: 'test-cases/manager/manager-regression-singleDC-set-distro.yaml',
 
     post_behavior_db_nodes: 'destroy',
     post_behavior_loader_nodes: 'destroy',
diff --git a/test-cases/manager/manager-regression-singleDC-set-distro.yaml b/test-cases/manager/manager-regression-singleDC-set-distro.yaml
new file mode 100644
index 0000000000..ef8a6d3553
--- /dev/null
+++ b/test-cases/manager/manager-regression-singleDC-set-distro.yaml
@@ -0,0 +1,21 @@
+test_duration: 240
+
+stress_cmd: "cassandra-stress write cl=QUORUM n=4000000 -schema 'replication(strategy=NetworkTopologyStrategy,replication_factor=3)' -mode cql3 native -rate threads=200 -pop seq=400000000..600000000"
+stress_read_cmd: "cassandra-stress read cl=QUORUM n=4000000 -schema 'replication(strategy=NetworkTopologyStrategy,replication_factor=3)' -mode cql3 native -rate threads=200 -pop seq=400000000..600000000"
+
+instance_type_db: 'i4i.large'
+instance_type_loader: 'c6i.large'
+
+region_name: 'us-east-1'
+n_db_nodes: '3'
+n_loaders: 1
+n_monitor_nodes: 1
+
+post_behavior_db_nodes: "destroy"
+post_behavior_loader_nodes: "destroy"
+post_behavior_monitor_nodes: "destroy"
+
+user_prefix: manager-regression
+space_node_threshold: 6442
+
+aws_instance_profile_name_db: 'qa-scylla-manager-backup-instance-profile'