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CCR5 replication
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README.md Create README.md Jun 4, 2019
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README.md

CCR5_replication

The 2019 paper "CCR5-∆32 is deleterious in the homozygous state in humans" looked like it could use some replication, so I did some.

I used UK Biobank data, restricted to white British unrelated participants from a quality-controlled subset, N = 337,008.

The .do file is a stripped down version of the code I ran to produce the analysis and graph.

While I can't share the individual participant data, anyone with access to UK Biobank data (field IDs in teh .do file plus genetic data) should be able to run a replication.

The way we defined and excluded participants is explained in the University of Bristol quality control documentation for UK Biobank genetic data: https://data.bris.ac.uk/datasets/1ovaau5sxunp2cv8rcy88688v/UK%20Biobank%20Genetic%20Data_MRC%20IEU%20Quality%20Control%20version%202.pdf

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