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CCR5 replication
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Failed to load latest commit information. Create Jun 4, 2019 Add files via upload Jun 4, 2019


The 2019 paper "CCR5-∆32 is deleterious in the homozygous state in humans" looked like it could use some replication, so I did some.

I used UK Biobank data, restricted to white British unrelated participants from a quality-controlled subset, N = 337,008.

The .do file is a stripped down version of the code I ran to produce the analysis and graph.

While I can't share the individual participant data, anyone with access to UK Biobank data (field IDs in teh .do file plus genetic data) should be able to run a replication.

The way we defined and excluded participants is explained in the University of Bristol quality control documentation for UK Biobank genetic data:

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