diff --git a/requirements.txt b/requirements.txt
index d3266b29bd1..71120381637 100755
--- a/requirements.txt
+++ b/requirements.txt
@@ -73,7 +73,6 @@ importlib-metadata==2.0.0;python_version<"3.6"
 virtualenv>=20.4.4
 pymysql==0.10.1;python_version<"3.6"
 pymysql==1.0.2;python_version>="3.6"
-brython==3.9.1
 pyotp==2.6.0
 boto==2.49.0
 cffi==1.14.5
diff --git a/setup.py b/setup.py
index 7ed95905c7b..74e99827477 100755
--- a/setup.py
+++ b/setup.py
@@ -179,7 +179,6 @@
         'virtualenv>=20.4.4',  # Sync with importlib-metadata and pathlib2
         'pymysql==0.10.1;python_version<"3.6"',
         'pymysql==1.0.2;python_version>="3.6"',
-        'brython==3.9.1',
         'pyotp==2.6.0',
         'boto==2.49.0',
         'cffi==1.14.5',