diff --git a/rules/prefer-node-append.js b/rules/prefer-node-append.js
index 73231b2281..efb841f9cb 100644
--- a/rules/prefer-node-append.js
+++ b/rules/prefer-node-append.js
@@ -2,17 +2,25 @@
 const getDocumentationUrl = require('./utils/get-documentation-url');
 const isValueNotUsable = require('./utils/is-value-not-usable');
 const methodSelector = require('./utils/method-selector');
+const {notDomNodeSelector} = require('./utils/not-dom-node');
 
 const message = 'Prefer `Node#append()` over `Node#appendChild()`.';
-const selector = methodSelector({
-	name: 'appendChild',
-	length: 1
-});
+const selector = [
+	methodSelector({
+		name: 'appendChild',
+		length: 1
+	}),
+	notDomNodeSelector({
+		node: 'callee.object'
+	}),
+	notDomNodeSelector({
+		node: 'arguments.0'
+	})
+].join('');
 
 const create = context => {
 	return {
 		[selector](node) {
-			// TODO: exclude those cases parent/child impossible to be `Node`
 			const fix = isValueNotUsable(node) ?
 				fixer => fixer.replaceText(node.callee.property, 'append') :
 				undefined;
diff --git a/rules/utils/not-dom-node.js b/rules/utils/not-dom-node.js
new file mode 100644
index 0000000000..cf146b68e1
--- /dev/null
+++ b/rules/utils/not-dom-node.js
@@ -0,0 +1,35 @@
+'use strict';
+
+// AST Types:
+// https://github.com/eslint/espree/blob/master/lib/ast-node-types.js#L18
+// Only types possible to be `callee` or `argument` listed
+const impossibleTypes = [
+	'ArrayExpression',
+	'ArrowFunctionExpression',
+	'ClassExpression',
+	'FunctionExpression',
+	'Literal',
+	'ObjectExpression',
+	'TemplateLiteral'
+];
+
+// We might need this later
+/* istanbul ignore next */
+const isNotDomNode = node => {
+	return impossibleTypes.includes(node.type) ||
+	(node.type === 'Identifier' && node.name === 'undefined');
+};
+
+const notDomNodeSelector = options => {
+	const {node} = options;
+
+	return [
+		...impossibleTypes.map(type => `[${node}.type!="${type}"]`),
+		`:not([${node}.type="Identifier"][${node}.name="undefined"])`
+	].join('');
+};
+
+module.exports = {
+	isNotDomNode,
+	notDomNodeSelector
+};
diff --git a/test/prefer-node-append.js b/test/prefer-node-append.js
index 8301c5cbad..758dba23e3 100644
--- a/test/prefer-node-append.js
+++ b/test/prefer-node-append.js
@@ -1,11 +1,12 @@
 import test from 'ava';
 import avaRuleTester from 'eslint-ava-rule-tester';
 import {outdent} from 'outdent';
+import notDomNodeTypes from './utils/not-dom-node-types';
 import rule from '../rules/prefer-node-append';
 
 const ruleTester = avaRuleTester(test, {
-	env: {
-		es6: true
+	parserOptions: {
+		ecmaVersion: 2020
 	}
 });
 
@@ -30,7 +31,11 @@ ruleTester.run('prefer-node-append', rule, {
 		// More or less argument(s)
 		'parent.appendChild(one, two);',
 		'parent.appendChild();',
-		'parent.appendChild(...argumentsArray)'
+		'parent.appendChild(...argumentsArray)',
+		// `callee.object` is not a DOM Node,
+		...notDomNodeTypes.map(data => `(${data}).appendChild(foo)`),
+		// First argument is not a DOM Node,
+		...notDomNodeTypes.map(data => `foo.appendChild(${data})`)
 	],
 	invalid: [
 		{
@@ -44,19 +49,19 @@ ruleTester.run('prefer-node-append', rule, {
 			errors: [error]
 		},
 		{
-			code: 'node.appendChild(null)',
-			output: 'node.append(null)',
+			code: 'node.appendChild(foo)',
+			output: 'node.append(foo)',
 			errors: [error]
 		},
 		{
 			code: outdent`
 				function foo() {
-					node.appendChild(null);
+					node.appendChild(bar);
 				}
 			`,
 			output: outdent`
 				function foo() {
-					node.append(null);
+					node.append(bar);
 				}
 			`,
 			errors: [error]
diff --git a/test/utils/not-dom-node-types.js b/test/utils/not-dom-node-types.js
new file mode 100644
index 0000000000..75df47bb2a
--- /dev/null
+++ b/test/utils/not-dom-node-types.js
@@ -0,0 +1,32 @@
+'use strict';
+
+module.exports = [
+	// ArrayExpression
+	'[]',
+	'[1]',
+	'[...elements]',
+	// ArrowFunctionExpression
+	'() => {}',
+	// ClassExpression
+	'class Node {}',
+	// FunctionExpression
+	'function() {}',
+	// Literal
+	'0',
+	'1',
+	'""',
+	'"string"',
+	'/regex/',
+	'null',
+	'0n',
+	'1n',
+	'true',
+	'false',
+	// ObjectExpression
+	'{}',
+	// TemplateLiteral
+	'`templateLiteral`',
+	// Undefined
+	'undefined'
+];
+