diff --git a/index.d.ts b/index.d.ts
index 013785fa8..e0126fee3 100644
--- a/index.d.ts
+++ b/index.d.ts
@@ -198,3 +198,36 @@ export type RequireAtLeastOne<ObjectType, KeysType extends keyof ObjectType = ke
 	}[KeysType]
 	// …then, make intersection types by adding the remaining properties to each mapped type.
 	& Omit<ObjectType, KeysType>;
+
+/*
+Create a type that requires at only one of the given properties. The remaining properties are kept as is.
+
+@example
+```
+import {RequireOnlyOne} from 'type-fest';
+
+type Responder = {
+	text: () => string;
+	json: () => string;
+
+	secure: boolean;
+};
+
+const responder: RequireOnlyOne<Responder, 'text' | 'json'> = {
+	json: () => '{"message": "ok"}',
+	secure: true
+};
+```
+*/
+export type RequireOnlyOne<ObjectType, KeysType extends keyof ObjectType = keyof ObjectType> =
+	{
+		// For each Key in KeysType make a mapped type
+		[Key in KeysType]: (
+			// …by picking that Key's type and making it required
+			Required<Pick<ObjectType, Key>> &
+			// …and adding the other keys in KeysType as optional and of type `never`
+			Partial<Record<Exclude<KeysType, Key>, never>>
+		)
+	}[KeysType]
+	// …then, make intersection types by adding the remaining properties to each mapped type.
+	& Omit<ObjectType, KeysType>;
diff --git a/readme.md b/readme.md
index d38e26035..e6408dbaa 100644
--- a/readme.md
+++ b/readme.md
@@ -66,6 +66,7 @@ See the [types file](index.d.ts) for complete docs.
 - `Merge` - Merge two types into a new type. Keys of the second type overrides keys of the first type.
 - `MergeExclusive` - Create a type that has mutually exclusive properties.
 - `RequireAtLeastOne` - Create a type that requires at least one of the given properties.
+- `RequireOnlyOne` - Create a type that requires only one of the given properties.
 - `LiteralUnion` - Allows creating a union type by combining primitive types and literal types without sacrificing auto-completion in IDEs for the literal type part of the union. Workaround for [Microsoft/TypeScript#29729](https://github.com/Microsoft/TypeScript/issues/29729).
 
 ### Miscellaneous
diff --git a/test-d/require-only-one.ts b/test-d/require-only-one.ts
new file mode 100644
index 000000000..138e5cffb
--- /dev/null
+++ b/test-d/require-only-one.ts
@@ -0,0 +1,38 @@
+import {expectType, expectError} from 'tsd';
+import {RequireOnlyOne} from '..';
+
+type SystemMessages = {
+	default: string;
+
+	macos?: string;
+	linux: string;
+	windows: string;
+
+	optional?: string;
+};
+
+type ValidMessages = RequireOnlyOne<SystemMessages, 'macos' | 'linux' | 'windows'>;
+const test = (_: ValidMessages): void => {};
+
+test({macos: 'hey', default: 'hello'});
+test({linux: 'sup', default: 'hello'});
+test({windows: 'hi', default: 'hello'});
+test({windows: 'hi', default: 'hello', optional: 'howdy'});
+
+const system = Math.random() > 0.5 ? {macos: 'hey'} : {linux: 'sup'};
+test({default: 'hello', ...system});
+
+expectError(test({}));
+expectError(test({macos: 'hey'}));
+expectError(test({default: 'hello'}));
+expectError(test({macos: 'hey', linux: 'sup', default: 'hello'}));
+expectError(test({macos: 'hey', default: 'hello', unknown: 'hmmm'}));
+
+// TODO: Should it eventually be possible to make this negative test pass?
+/*
+const invalidSystem = Math.random() > 0.5 ? {default: 'hello', macos: 'hey', a: 1, b: 3} : {default: 'hello', linux: 'sup', b: 2};
+expectError(test(invalidSystem));
+*/
+
+declare const onlyOneWithoutKeys: RequireOnlyOne<{a: number; b: number}>;
+expectType<{a: number} | {b: number}>(onlyOneWithoutKeys);