I think there's something wrong with me
What do you think is wrong with you?
My brain seems defective, because I often feel despair.
We all feel inadequate sometimes. But if you feel despair a lot of time, it's worth seeing a professional to find out if anything can be done about it.
Maybe I think I just need to collect some more memes.
I understand you are just trying to cheer yourself up, but don't you want to feel better for longer periods of time? Memes aren't going to cure things, so why not try talking to a psychiatrist? You never know if they'll become a great friend!