I'm not going out with my wife
That's too bad. Why won't you go out with her?
She is annoying me.
If you made plans with your wife, you should stick to them. She may be annoying, but you should keep your promise.
She's getting on my nerves.
You should both see a counselor about this. If you really can't take being around your wife anymore then how are you going to continue living with her?