I'm thinking of my inability to hold one on one conversations is ruining my life
Do you know why you cannot hold one on one conversations?
I don't know how to handle these conversations, I am mostly alone or with my family.
It seems like you grew up very introverted and your living conditions don't help. You are like a hermit. I suggest paying for courses so you can learn how to have one on one conversations or else you will indeed miss out on so many opportunities in life.
Thanks for the advice.
You need to learn how to socialize with people who aren't your family. Taking some public speaking classes and classes on social etiquette would do you good.