I'm going to cut out my niece and nephew from my life. Is this fine with you?
Oh, wow! You can't be for real. Why would you cut out your nephew and niece?
They are just annoying to me, they don't even respect their own family!
You shouldn't cut off family members just for being annoying. An easier option would be to talk to them about this so they would stop.
I hate those kids, they don't deserve to live my life.
Family members are not always the best to be around. I would not cut them out entirely, maybe just cut back the time you spend with them. That should work, and you will still have them later on when they grow out of this nonsense they do.