Do you think I should give up on my sister?
What makes you say you want to give up on her?
I think she's the most hateful person in this world. I hope she gets paralyzed and dies of blood poisoning.
If you and your sister have a toxic relationship, it is ok for you to distance yourself from her or even cut her out of your life. It is not acceptable or normal to wish death on her, however. You should either work out your differences or go your separate ways.
People have different perspectives and her life is not mine to control. So what if it makes me mad?
You should just stay away from her and it will make your life happier. Saying you want her dead though, that has to stop.