diff --git a/Phenotype_Categories.md b/Phenotype_Categories.md new file mode 100644 index 0000000..fe34e51 --- /dev/null +++ b/Phenotype_Categories.md @@ -0,0 +1,350 @@ +# Mapping 306 CALIBER phenotypes to 16 disease categories + +This maps 306 of the CALIBER phenotypes by *Kuan et al.* to the following 16 categories: + +* Diseases of the Circulatory System +* Diseases of the Digestive System +* Skin conditions +* Diseases of the Genitourinary system +* Haematological/Immunological conditions +* Mental Health Disorders +* Diseases of the Respiratory System +* Musculoskeletal conditions +* Diseases of the Eye +* Neurological conditions +* Infectious Diseases +* Benign Neoplasm/CIN +* Perinatal conditions +* Diseases of the Endocrine System +* Diseases of the Ear +* Cancers + +These 16 categories are taken from *Supplementary Table S1. Medical Conditions with the abbreviated terms used in this article and their disease categories* from the paper: + +
+ +>Kuan V., Denaxas S., Gonzalez-Izquierdo A. et al. _A chronological map of 308 physical and mental health conditions from 4 million individuals in the National Health Service_ published in the Lancet Digital Health - DOI 10.1016/S2589-7500(19)30012-3 + +
+ +Please note: +* *Supplementary Table S1* does not provide a direct mapping to CALIBER phenotypes and there are cases where different names are used (e.g. `Scleroderma` vs `Systemic Sclerosis`). +* Conditions `Type 1 Diabetes Mellitus` and `Type 2 Diabetes Mellitus` are present in *Supplementary Table S1* but not listed as phenotypes within `dictionary.csv` and therefore these conditions are not included in the mapping (although they would be classified under `Diseases of the Endocrine System`) + +
+ +The below mapping is produced and shared by [Dr Chris Tomlinson](https://ctomlinson.net). + +
+ +# `phenotype_categories_mapping.csv` +Content reproduced in markdown below for ease of browsing: + +| Phenotype | Category | +|-------------------------------------------------------------------------------|-----------------------------------------| +| Abdominal aortic aneurysm | Diseases of the Circulatory System | +| Abdominal Hernia | Diseases of the Digestive System | +| Acne | Skin conditions | +| Actinic keratosis | Skin conditions | +| Acute Kidney Injury | Diseases of the Genitourinary system | +| Agranulocytosis | Haematological/Immunological conditions | +| Alcohol Problems | Mental Health Disorders | +| Alcoholic liver disease | Diseases of the Digestive System | +| Allergic and chronic rhinitis | Diseases of the Respiratory System | +| Alopecia areata | Skin conditions | +| Other anaemias | Haematological/Immunological conditions | +| Anal fissure | Diseases of the Digestive System | +| Angiodysplasia of colon | Diseases of the Digestive System | +| Ankylosing spondylitis | Musculoskeletal conditions | +| Anorectal fistula | Diseases of the Digestive System | +| Anorectal prolapse | Diseases of the Digestive System | +| Anterior and Intermediate Uveitis | Diseases of the Eye | +| Anxiety disorders | Mental Health Disorders | +| Aplastic anaemias | Haematological/Immunological conditions | +| Appendicitis | Diseases of the Digestive System | +| Asbestosis | Diseases of the Respiratory System | +| Aspiration pneumonitis | Diseases of the Respiratory System | +| Asthma | Diseases of the Respiratory System | +| Atrial fibrillation | Diseases of the Circulatory System | +| Atrioventricular block, first degree | Diseases of the Circulatory System | +| Atrioventricular block, second degree | Diseases of the Circulatory System | +| Atrioventricular block, complete | Diseases of the Circulatory System | +| Autism and Asperger's syndrome | Mental Health Disorders | +| Autoimmune liver disease | Diseases of the Digestive System | +| Disorders of autonomic nervous system | Neurological conditions | +| Bacterial Diseases (excl TB) | Infectious Diseases | +| Barrett's oesophagus | Diseases of the Digestive System | +| Bell's palsy | Neurological conditions | +| Benign neoplasm of brain and other parts of central nervous system | Benign Neoplasm/CIN | +| Benign neoplasm of colon, rectum, anus and anal canal | Benign Neoplasm/CIN | +| Benign neoplasm of ovary | Benign Neoplasm/CIN | +| Benign neoplasm of stomach and duodenum | Benign Neoplasm/CIN | +| Benign neoplasm and polyp of uterus | Benign Neoplasm/CIN | +| Hyperplasia of prostate | Diseases of the Genitourinary system | +| Bifascicular block | Diseases of the Circulatory System | +| Bipolar affective disorder and mania | Mental Health Disorders | +| Visual impairment and blindness | Diseases of the Eye | +| Bronchiectasis | Diseases of the Respiratory System | +| Other Cardiomyopathy | Diseases of the Circulatory System | +| Carpal tunnel syndrome | Musculoskeletal conditions | +| Cataract | Diseases of the Eye | +| Cerebral Palsy | Neurological conditions | +| Carcinoma in situ_cervical | Benign Neoplasm/CIN | +| Cholangitis | Diseases of the Digestive System | +| Cholecystitis | Diseases of the Digestive System | +| Cholelithiasis | Diseases of the Digestive System | +| Non-acute cystitis | Diseases of the Genitourinary system | +| Postviral fatigue syndrome, neurasthenia and fibromyalgia | Neurological conditions | +| Chronic Kidney Disease | Diseases of the Genitourinary system | +| COPD | Diseases of the Respiratory System | +| Chronic sinusitis | Diseases of the Respiratory System | +| Chronic viral hepatitis | Infectious Diseases | +| Liver fibrosis, sclerosis and cirrhosis | Diseases of the Digestive System | +| Coeliac disease | Diseases of the Digestive System | +| Collapsed vertebra | Musculoskeletal conditions | +| Congenital malformations of cardiac septa | Perinatal conditions | +| Coronary heart disease not otherwise specified | Diseases of the Circulatory System | +| Crohn's disease | Diseases of the Digestive System | +| Cystic Fibrosis | Diseases of the Endocrine System | +| Hearing loss | Diseases of the Ear | +| Delirium, not induced by alcohol and other psychoactive substances | Mental Health Disorders | +| Dementia | Mental Health Disorders | +| Depression | Mental Health Disorders | +| Dermatitis (atopc/contact/other/unspecified) | Skin conditions | +| Diabetes | Diseases of the Endocrine System | +| Diabetic ophthalmic complications | Diseases of the Eye | +| Diabetic neurological complications | Neurological conditions | +| Diaphragmatic hernia | Diseases of the Digestive System | +| Dilated cardiomyopathy | Diseases of the Circulatory System | +| Diverticular disease of intestine (acute and chronic) | Diseases of the Digestive System | +| Down's syndrome | Perinatal conditions | +| Dysmenorrhoea | Diseases of the Genitourinary system | +| Anorexia and bulimia nervosa | Mental Health Disorders | +| Encephalitis | Infectious Diseases | +| End stage renal disease | Diseases of the Genitourinary system | +| Endometrial hyperplasia and hypertrophy | Diseases of the Genitourinary system | +| Endometriosis | Diseases of the Genitourinary system | +| Enteropathic arthropathy | Musculoskeletal conditions | +| Enthesopathies & synovial disorders | Musculoskeletal conditions | +| Epilepsy | Neurological conditions | +| Erectile dysfunction | Diseases of the Genitourinary system | +| Essential tremor | Neurological conditions | +| Fatty Liver | Diseases of the Digestive System | +| Female infertility | Diseases of the Genitourinary system | +| Fibromatoses | Musculoskeletal conditions | +| Folate deficiency anaemia | Haematological/Immunological conditions | +| Fracture of hip | Musculoskeletal conditions | +| Fracture of wrist | Musculoskeletal conditions | +| Mycoses | Infectious Diseases | +| Gastritis and duodenitis | Diseases of the Digestive System | +| Gastro-oesophageal reflux disease | Diseases of the Digestive System | +| Giant Cell arteritis | Musculoskeletal conditions | +| Glaucoma | Diseases of the Eye | +| Glomerulonephritis | Diseases of the Genitourinary system | +| Gout | Musculoskeletal conditions | +| Haemangioma, any site | Benign Neoplasm/CIN | +| Heart failure | Diseases of the Circulatory System | +| Hidradenitis suppurativa | Skin conditions | +| High birth weight | Perinatal conditions | +| HIV | Infectious Diseases | +| Hodgkin Lymphoma | Cancers | +| Hydrocoele (incl infected) | Diseases of the Genitourinary system | +| Hyperkinetic disorders | Mental Health Disorders | +| Hyperparathyroidism | Diseases of the Endocrine System | +| Splenomegaly | Haematological/Immunological conditions | +| Hypertension | Diseases of the Circulatory System | +| Hypertrophic Cardiomyopathy | Diseases of the Circulatory System | +| Hypertrophy of nasal turbinates | Diseases of the Respiratory System | +| Hyposplenism | Haematological/Immunological conditions | +| Intracranial hypertension | Neurological conditions | +| Immunodeficiencies | Haematological/Immunological conditions | +| Infection of anal and rectal regions | Infectious Diseases | +| Infection of bones and joints | Infectious Diseases | +| Infections of the digestive system | Infectious Diseases | +| Ear and Upper Respiratory Tract Infections | Infectious Diseases | +| Eye infections | Infectious Diseases | +| Infections of the Heart | Infectious Diseases | +| Infection of liver | Infectious Diseases | +| Lower Respiratory Tract Infections | Infectious Diseases | +| Infection of male genital system | Infectious Diseases | +| Infection of other or unspecified genitourinary system | Infectious Diseases | +| Other nervous system infections | Infectious Diseases | +| Other or unspecified infectious organisms | Infectious Diseases | +| Infections of Other or unspecified organs | Infectious Diseases | +| Infection of skin and subcutaneous tissues | Infectious Diseases | +| Intellectual disability | Mental Health Disorders | +| Intervertebral disc disorders | Musculoskeletal conditions | +| Intracerebral haemorrhage | Diseases of the Circulatory System | +| Intrauterine hypoxia | Perinatal conditions | +| Iron deficiency anaemia | Haematological/Immunological conditions | +| Irritable bowel syndrome | Diseases of the Digestive System | +| Ischaemic stroke | Diseases of the Circulatory System | +| Juvenile arthritis | Musculoskeletal conditions | +| Keratitis | Diseases of the Eye | +| Left bundle branch block | Diseases of the Circulatory System | +| Leiomyoma of uterus | Benign Neoplasm/CIN | +| Leukaemia | Cancers | +| Lichen planus | Skin conditions | +| Hepatic failure | Diseases of the Digestive System | +| Slow fetal growth or low birth weight | Perinatal conditions | +| Low HDL-C | Diseases of the Endocrine System | +| Lupus erythematosus (local and systemic) | Musculoskeletal conditions | +| Macular degeneration | Diseases of the Eye | +| Male infertility | Diseases of the Genitourinary system | +| Meniere disease | Diseases of the Ear | +| Meningitis | Infectious Diseases | +| Menorrhagia and polymenorrhoea | Diseases of the Genitourinary system | +| Migraine | Neurological conditions | +| Monoclonal gammopathy of undetermined significance (MGUS) | Cancers | +| Motor neuron disease | Neurological conditions | +| Multiple sclerosis | Neurological conditions | +| Multiple valve dz | Diseases of the Circulatory System | +| Myasthenia gravis | Neurological conditions | +| Myelodysplastic syndromes | Cancers | +| Myocardial infarction | Diseases of the Circulatory System | +| Nasal polyp | Diseases of the Respiratory System | +| Neonatal jaundice (excl haemolytic dz of the newborn) | Perinatal conditions | +| Neuromuscular dysfunction of bladder | Diseases of the Genitourinary system | +| Non-Hodgkin Lymphoma | Cancers | +| Nonrheumatic aortic valve disorders | Diseases of the Circulatory System | +| Nonrheumatic mitral valve disorders | Diseases of the Circulatory System | +| Obesity | Diseases of the Endocrine System | +| Obsessive-compulsive disorder | Mental Health Disorders | +| Obstructive and reflux uropathy | Diseases of the Genitourinary system | +| Oesophagitis and oesophageal ulcer | Diseases of the Digestive System | +| Oesophageal varices | Diseases of the Digestive System | +| Osteoarthritis (excl spine) | Musculoskeletal conditions | +| Osteoporosis | Musculoskeletal conditions | +| Other haemolytic anaemias | Haematological/Immunological conditions | +| Pancreatitis | Diseases of the Digestive System | +| Parasitic infections | Infectious Diseases | +| Parkinson's disease | Neurological conditions | +| Patent ductus arteriosus | Perinatal conditions | +| Female pelvic inflammatory disease | Infectious Diseases | +| Peptic ulcer disease | Diseases of the Digestive System | +| Pericardial effusion (noninflammatory) | Diseases of the Circulatory System | +| Peripheral arterial disease | Diseases of the Circulatory System | +| Peripheral neuropathies (excluding cranial nerve and carpal tunnel syndromes) | Neurological conditions | +| Peritonitis | Diseases of the Digestive System | +| Personality disorders | Mental Health Disorders | +| Pilonidal cyst/sinus | Skin conditions | +| Multiple myeloma and malignant plasma cell neoplasms | Cancers | +| Pleural effusion | Diseases of the Respiratory System | +| Pleural plaque | Diseases of the Respiratory System | +| Pneumothorax | Diseases of the Respiratory System | +| Polycystic ovarian syndrome | Diseases of the Endocrine System | +| Polycythaemia vera | Cancers | +| Polymyalgia Rheumatica | Musculoskeletal conditions | +| Portal hypertension | Diseases of the Digestive System | +| Post-term infant | Perinatal conditions | +| Postcoital and contact bleeding | Diseases of the Genitourinary system | +| Posterior Uveitis | Diseases of the Eye | +| Postmenopausal bleeding | Diseases of the Genitourinary system | +| Prematurity | Perinatal conditions | +| Primary Malignancy_biliary tract | Cancers | +| Primary Malignancy_Bladder | Cancers | +| Primary Malignancy_Bone and articular cartilage | Cancers | +| Primary Malignancy_colorectal and anus | Cancers | +| Primary Malignancy_Brain, Other CNS and Intracranial | Cancers | +| Primary Malignancy_Breast | Cancers | +| Primary Malignancy_Cervical | Cancers | +| Primary Malignancy_Kidney and Ureter | Cancers | +| Primary Malignancy_Liver | Cancers | +| Primary Malignancy_Lung and trachea | Cancers | +| Primary Malignancy_Malignant Melanoma | Cancers | +| Primary Malignancy_Mesothelioma | Cancers | +| Primary Malignancy_Multiple independent sites | Cancers | +| Primary Malignancy_Oesophageal | Cancers | +| Primary Malignancy_Oro-pharyngeal | Cancers | +| Primary Malignancy_Other Organs | Cancers | +| Primary Malignancy_Ovarian | Cancers | +| Primary Malignancy_Pancreatic | Cancers | +| Primary Malignancy_Prostate | Cancers | +| Primary Malignancy_Other Skin and subcutaneous tissue | Cancers | +| Primary Malignancy_Stomach | Cancers | +| Primary Malignancy_Testicular | Cancers | +| Primary Malignancy_Thyroid | Cancers | +| Primary Malignancy_Uterine | Cancers | +| Primary pulmonary hypertension | Diseases of the Circulatory System | +| Primary or Idiopathic Thrombocytopaenia | Haematological/Immunological conditions | +| Psoriasis | Skin conditions | +| Psoriatic arthropathy | Musculoskeletal conditions | +| Ptosis of eyelid | Diseases of the Eye | +| Pulmonary collapse (excl pneumothorax) | Diseases of the Respiratory System | +| Pulmonary embolism | Diseases of the Circulatory System | +| Other interstitial pulmonary diseases with fibrosis | Diseases of the Respiratory System | +| Raised LDL-C | Diseases of the Endocrine System | +| Raised Total Cholesterol | Diseases of the Endocrine System | +| Raised Triglycerides | Diseases of the Endocrine System | +| Raynaud's syndrome | Diseases of the Circulatory System | +| Postinfective and reactive arthropathies | Musculoskeletal conditions | +| Respiratory distress of newborn | Perinatal conditions | +| Respiratory failure | Diseases of the Respiratory System | +| Retinal detachments and breaks | Diseases of the Eye | +| Retinal vascular occlusions | Diseases of the Eye | +| Rheumatic fever | Infectious Diseases | +| Rheumatic valve dz | Diseases of the Circulatory System | +| Rheumatoid Arthritis | Musculoskeletal conditions | +| Right bundle branch block | Diseases of the Circulatory System | +| Rosacea | Skin conditions | +| Sarcoidosis | Haematological/Immunological conditions | +| Schizophrenia, schizotypal and delusional disorders | Mental Health Disorders | +| Scleritis and episcleritis | Diseases of the Eye | +| Systemic sclerosis | Musculoskeletal conditions | +| Scoliosis | Musculoskeletal conditions | +| Seborrheic dermatitis | Skin conditions | +| Secondary Malignancy_Adrenal gland | Cancers | +| Secondary Malignancy_Bone | Cancers | +| Secondary Malignancy_Bowel | Cancers | +| Secondary Malignancy_Brain, Other CNS and Intracranial | Cancers | +| Secondary malignancy_Liver and intrahepatic bile duct | Cancers | +| Secondary Malignancy_Lung | Cancers | +| Secondary Malignancy_Lymph Nodes | Cancers | +| Secondary Malignancy_Other organs | Cancers | +| Secondary Malignancy_retroperitoneum and peritoneum | Cancers | +| Secondary Malignancy_Pleura | Cancers | +| Secondary polycythaemia | Haematological/Immunological conditions | +| Secondary pulmonary hypertension | Diseases of the Circulatory System | +| Secondary or other Thrombocytopaenia | Haematological/Immunological conditions | +| Bacterial sepsis of newborn | Perinatal conditions | +| Septicaemia | Infectious Diseases | +| Sick sinus syndrome | Diseases of the Circulatory System | +| Sickle-cell anaemia | Haematological/Immunological conditions | +| Sickle-cell trait | Haematological/Immunological conditions | +| Sjogren's disease | Musculoskeletal conditions | +| Sleep apnoea | Diseases of the Respiratory System | +| Spina bifida | Perinatal conditions | +| Spinal stenosis | Musculoskeletal conditions | +| Spondylolisthesis | Musculoskeletal conditions | +| Spondylosis | Musculoskeletal conditions | +| Stable angina | Diseases of the Circulatory System | +| Stroke NOS | Diseases of the Circulatory System | +| Subarachnoid haemorrhage | Diseases of the Circulatory System | +| Subdural haematoma - nontraumatic | Diseases of the Circulatory System | +| Other psychoactive substance misuse | Mental Health Disorders | +| Supraventricular tachycardia | Diseases of the Circulatory System | +| Syndrome of inappropriate secretion of antidiuretic hormone | Diseases of the Endocrine System | +| Thalassaemia | Haematological/Immunological conditions | +| Thalassaemia trait | Haematological/Immunological conditions | +| Thrombophilia | Haematological/Immunological conditions | +| Hypo or hyperthyroidism | Diseases of the Endocrine System | +| Tinnitus | Diseases of the Ear | +| Transient ischaemic attack | Diseases of the Circulatory System | +| Trifascicular block | Diseases of the Circulatory System | +| Trigeminal neuralgia | Neurological conditions | +| Tuberculosis | Infectious Diseases | +| Tubulo-interstitial nephritis | Diseases of the Genitourinary system | +| Ulcerative colitis | Diseases of the Digestive System | +| Undescended testicle | Diseases of the Genitourinary system | +| Unstable Angina | Diseases of the Circulatory System | +| Urinary Incontinence | Diseases of the Genitourinary system | +| Urinary Tract Infections | Infectious Diseases | +| Urolithiasis | Diseases of the Genitourinary system | +| Urticaria | Skin conditions | +| Female genital prolapse | Diseases of the Genitourinary system | +| Venous thromboembolic disease (Excl PE) | Diseases of the Circulatory System | +| Ventricular tachycardia | Diseases of the Circulatory System | +| Viral diseases (excl chronic hepatitis/HIV) | Infectious Diseases | +| Vitamin B12 deficiency anaemia | Haematological/Immunological conditions | +| Vitiligo | Skin conditions | +| Volvulus | Diseases of the Digestive System | \ No newline at end of file diff --git a/phenotype_categories_mapping.csv b/phenotype_categories_mapping.csv new file mode 100644 index 0000000..91360cb --- /dev/null +++ b/phenotype_categories_mapping.csv @@ -0,0 +1,309 @@ +Phenotype,Category +Abdominal aortic aneurysm,Diseases of the Circulatory System +Abdominal Hernia,Diseases of the Digestive System +Acne,Skin conditions +Actinic keratosis,Skin conditions +Acute Kidney Injury,Diseases of the Genitourinary system +Agranulocytosis,Haematological/Immunological conditions +Alcohol Problems,Mental Health Disorders +Alcoholic liver disease,Diseases of the Digestive System +Allergic and chronic rhinitis,Diseases of the Respiratory System +Alopecia areata,Skin conditions +Other anaemias,Haematological/Immunological conditions +Anal fissure,Diseases of the Digestive System +Angiodysplasia of colon,Diseases of the Digestive System +Ankylosing spondylitis,Musculoskeletal conditions +Anorectal fistula,Diseases of the Digestive System +Anorectal prolapse,Diseases of the Digestive System +Anterior and Intermediate Uveitis,Diseases of the Eye +Anxiety disorders,Mental Health Disorders +Aplastic anaemias,Haematological/Immunological conditions +Appendicitis,Diseases of the Digestive System +Asbestosis,Diseases of the Respiratory System +Aspiration pneumonitis,Diseases of the Respiratory System +Asthma,Diseases of the Respiratory System +Atrial fibrillation,Diseases of the Circulatory System +"Atrioventricular block, first degree",Diseases of the Circulatory System +"Atrioventricular block, second degree",Diseases of the Circulatory System +"Atrioventricular block, complete",Diseases of the Circulatory System +Autism and Asperger's syndrome,Mental Health Disorders +Autoimmune liver disease,Diseases of the Digestive System +Disorders of autonomic nervous system,Neurological conditions +Bacterial Diseases (excl TB),Infectious Diseases +Barrett's oesophagus,Diseases of the Digestive System +Bell's palsy,Neurological conditions +Benign neoplasm of brain and other parts of central nervous system,Benign Neoplasm/CIN +"Benign neoplasm of colon, rectum, anus and anal canal",Benign Neoplasm/CIN +Benign neoplasm of ovary,Benign Neoplasm/CIN +Benign neoplasm of stomach and duodenum,Benign Neoplasm/CIN +Benign neoplasm and polyp of uterus,Benign Neoplasm/CIN +Hyperplasia of prostate,Diseases of the Genitourinary system +Bifascicular block,Diseases of the Circulatory System +Bipolar affective disorder and mania,Mental Health Disorders +Visual impairment and blindness,Diseases of the Eye +Bronchiectasis,Diseases of the Respiratory System +Other Cardiomyopathy,Diseases of the Circulatory System +Carpal tunnel syndrome,Musculoskeletal conditions +Cataract,Diseases of the Eye +Cerebral Palsy,Neurological conditions +Carcinoma in situ_cervical,Benign Neoplasm/CIN +Cholangitis,Diseases of the Digestive System +Cholecystitis,Diseases of the Digestive System +Cholelithiasis,Diseases of the Digestive System +Non-acute cystitis,Diseases of the Genitourinary system +"Postviral fatigue syndrome, neurasthenia and fibromyalgia",Neurological conditions +Chronic Kidney Disease,Diseases of the Genitourinary system +COPD,Diseases of the Respiratory System +Chronic sinusitis,Diseases of the Respiratory System +Chronic viral hepatitis,Infectious Diseases +"Liver fibrosis, sclerosis and cirrhosis",Diseases of the Digestive System +Coeliac disease,Diseases of the Digestive System +Collapsed vertebra,Musculoskeletal conditions +Congenital malformations of cardiac septa,Perinatal conditions +Coronary heart disease not otherwise specified,Diseases of the Circulatory System +Crohn's disease,Diseases of the Digestive System +Cystic Fibrosis,Diseases of the Endocrine System +Hearing loss,Diseases of the Ear +"Delirium, not induced by alcohol and other psychoactive substances",Mental Health Disorders +Dementia,Mental Health Disorders +Depression,Mental Health Disorders +Dermatitis (atopc/contact/other/unspecified),Skin conditions +Diabetes,Diseases of the Endocrine System +Diabetic ophthalmic complications,Diseases of the Eye +Diabetic neurological complications,Neurological conditions +Diaphragmatic hernia,Diseases of the Digestive System +Dilated cardiomyopathy,Diseases of the Circulatory System +Diverticular disease of intestine (acute and chronic),Diseases of the Digestive System +Down's syndrome,Perinatal conditions +Dysmenorrhoea,Diseases of the Genitourinary system +Anorexia and bulimia nervosa,Mental Health Disorders +Encephalitis,Infectious Diseases +End stage renal disease,Diseases of the Genitourinary system +Endometrial hyperplasia and hypertrophy,Diseases of the Genitourinary system +Endometriosis,Diseases of the Genitourinary system +Enteropathic arthropathy,Musculoskeletal conditions +Enthesopathies & synovial disorders,Musculoskeletal conditions +Epilepsy,Neurological conditions +Erectile dysfunction,Diseases of the Genitourinary system +Essential tremor,Neurological conditions +Fatty Liver,Diseases of the Digestive System +Female infertility,Diseases of the Genitourinary system +Fibromatoses,Musculoskeletal conditions +Folate deficiency anaemia,Haematological/Immunological conditions +Fracture of hip,Musculoskeletal conditions +Fracture of wrist,Musculoskeletal conditions +Mycoses,Infectious Diseases +Gastritis and duodenitis,Diseases of the Digestive System +Gastro-oesophageal reflux disease,Diseases of the Digestive System +Giant Cell arteritis,Musculoskeletal conditions +Glaucoma,Diseases of the Eye +Glomerulonephritis,Diseases of the Genitourinary system +Gout,Musculoskeletal conditions +"Haemangioma, any site",Benign Neoplasm/CIN +Heart failure,Diseases of the Circulatory System +Hidradenitis suppurativa,Skin conditions +High birth weight,Perinatal conditions +HIV,Infectious Diseases +Hodgkin Lymphoma,Cancers +Hydrocoele (incl infected),Diseases of the Genitourinary system +Hyperkinetic disorders,Mental Health Disorders +Hyperparathyroidism,Diseases of the Endocrine System +Splenomegaly,Haematological/Immunological conditions +Hypertension,Diseases of the Circulatory System +Hypertrophic Cardiomyopathy,Diseases of the Circulatory System +Hypertrophy of nasal turbinates,Diseases of the Respiratory System +Hyposplenism,Haematological/Immunological conditions +Intracranial hypertension,Neurological conditions +Immunodeficiencies,Haematological/Immunological conditions +Infection of anal and rectal regions,Infectious Diseases +Infection of bones and joints,Infectious Diseases +Infections of the digestive system,Infectious Diseases +Ear and Upper Respiratory Tract Infections,Infectious Diseases +Eye infections,Infectious Diseases +Infections of the Heart,Infectious Diseases +Infection of liver,Infectious Diseases +Lower Respiratory Tract Infections,Infectious Diseases +Infection of male genital system,Infectious Diseases +Infection of other or unspecified genitourinary system,Infectious Diseases +Other nervous system infections,Infectious Diseases +Other or unspecified infectious organisms,Infectious Diseases +Infections of Other or unspecified organs,Infectious Diseases +Infection of skin and subcutaneous tissues,Infectious Diseases +Intellectual disability,Mental Health Disorders +Intervertebral disc disorders,Musculoskeletal conditions +Intracerebral haemorrhage,Diseases of the Circulatory System +Intrauterine hypoxia,Perinatal conditions +Iron deficiency anaemia,Haematological/Immunological conditions +Irritable bowel syndrome,Diseases of the Digestive System +Ischaemic stroke,Diseases of the Circulatory System +Juvenile arthritis,Musculoskeletal conditions +Keratitis,Diseases of the Eye +Left bundle branch block,Diseases of the Circulatory System +Leiomyoma of uterus,Benign Neoplasm/CIN +Leukaemia,Cancers +Lichen planus,Skin conditions +Hepatic failure,Diseases of the Digestive System +Slow fetal growth or low birth weight,Perinatal conditions +Low HDL-C,Diseases of the Endocrine System +Lupus erythematosus (local and systemic),Musculoskeletal conditions +Macular degeneration,Diseases of the Eye +Male infertility,Diseases of the Genitourinary system +Meniere disease,Diseases of the Ear +Meningitis,Infectious Diseases +Menorrhagia and polymenorrhoea,Diseases of the Genitourinary system +Migraine,Neurological conditions +Monoclonal gammopathy of undetermined significance (MGUS),Cancers +Motor neuron disease,Neurological conditions +Multiple sclerosis,Neurological conditions +Multiple valve dz,Diseases of the Circulatory System +Myasthenia gravis,Neurological conditions +Myelodysplastic syndromes,Cancers +Myocardial infarction,Diseases of the Circulatory System +Nasal polyp,Diseases of the Respiratory System +Neonatal jaundice (excl haemolytic dz of the newborn),Perinatal conditions +Neuromuscular dysfunction of bladder,Diseases of the Genitourinary system +Non-Hodgkin Lymphoma,Cancers +Nonrheumatic aortic valve disorders,Diseases of the Circulatory System +Nonrheumatic mitral valve disorders,Diseases of the Circulatory System +Obesity,Diseases of the Endocrine System +Obsessive-compulsive disorder,Mental Health Disorders +Obstructive and reflux uropathy,Diseases of the Genitourinary system +Oesophagitis and oesophageal ulcer,Diseases of the Digestive System +Oesophageal varices,Diseases of the Digestive System +Osteoarthritis (excl spine),Musculoskeletal conditions +Osteoporosis,Musculoskeletal conditions +Other haemolytic anaemias,Haematological/Immunological conditions +Pancreatitis,Diseases of the Digestive System +Parasitic infections,Infectious Diseases +Parkinson's disease,Neurological conditions +Patent ductus arteriosus,Perinatal conditions +Female pelvic inflammatory disease,Infectious Diseases +Peptic ulcer disease,Diseases of the Digestive System +Pericardial effusion (noninflammatory),Diseases of the Circulatory System +Peripheral arterial disease,Diseases of the Circulatory System +Peripheral neuropathies (excluding cranial nerve and carpal tunnel syndromes),Neurological conditions +Peritonitis,Diseases of the Digestive System +Personality disorders,Mental Health Disorders +Pilonidal cyst/sinus,Skin conditions +Multiple myeloma and malignant plasma cell neoplasms,Cancers +Pleural effusion,Diseases of the Respiratory System +Pleural plaque,Diseases of the Respiratory System +Pneumothorax,Diseases of the Respiratory System +Polycystic ovarian syndrome,Diseases of the Endocrine System +Polycythaemia vera,Cancers +Polymyalgia Rheumatica,Musculoskeletal conditions +Portal hypertension,Diseases of the Digestive System +Post-term infant,Perinatal conditions +Postcoital and contact bleeding,Diseases of the Genitourinary system +Posterior Uveitis,Diseases of the Eye +Postmenopausal bleeding,Diseases of the Genitourinary system +Prematurity,Perinatal conditions +Primary Malignancy_biliary tract,Cancers +Primary Malignancy_Bladder,Cancers +Primary Malignancy_Bone and articular cartilage,Cancers +Primary Malignancy_colorectal and anus,Cancers +"Primary Malignancy_Brain, Other CNS and Intracranial",Cancers +Primary Malignancy_Breast,Cancers +Primary Malignancy_Cervical,Cancers +Primary Malignancy_Kidney and Ureter,Cancers +Primary Malignancy_Liver,Cancers +Primary Malignancy_Lung and trachea,Cancers +Primary Malignancy_Malignant Melanoma,Cancers +Primary Malignancy_Mesothelioma,Cancers +Primary Malignancy_Multiple independent sites,Cancers +Primary Malignancy_Oesophageal,Cancers +Primary Malignancy_Oro-pharyngeal,Cancers +Primary Malignancy_Other Organs,Cancers +Primary Malignancy_Ovarian,Cancers +Primary Malignancy_Pancreatic,Cancers +Primary Malignancy_Prostate,Cancers +Primary Malignancy_Other Skin and subcutaneous tissue,Cancers +Primary Malignancy_Stomach,Cancers +Primary Malignancy_Testicular,Cancers +Primary Malignancy_Thyroid,Cancers +Primary Malignancy_Uterine,Cancers +Primary pulmonary hypertension,Diseases of the Circulatory System +Primary or Idiopathic Thrombocytopaenia,Haematological/Immunological conditions +Psoriasis,Skin conditions +Psoriatic arthropathy,Musculoskeletal conditions +Ptosis of eyelid,Diseases of the Eye +Pulmonary collapse (excl pneumothorax),Diseases of the Respiratory System +Pulmonary embolism,Diseases of the Circulatory System +Other interstitial pulmonary diseases with fibrosis,Diseases of the Respiratory System +Raised LDL-C,Diseases of the Endocrine System +Raised Total Cholesterol,Diseases of the Endocrine System +Raised Triglycerides,Diseases of the Endocrine System +Raynaud's syndrome,Diseases of the Circulatory System +Postinfective and reactive arthropathies,Musculoskeletal conditions +Respiratory distress of newborn,Perinatal conditions +Respiratory failure,Diseases of the Respiratory System +Retinal detachments and breaks,Diseases of the Eye +Retinal vascular occlusions,Diseases of the Eye +Rheumatic fever,Infectious Diseases +Rheumatic valve dz,Diseases of the Circulatory System +Rheumatoid Arthritis,Musculoskeletal conditions +Right bundle branch block,Diseases of the Circulatory System +Rosacea,Skin conditions +Sarcoidosis,Haematological/Immunological conditions +"Schizophrenia, schizotypal and delusional disorders",Mental Health Disorders +Scleritis and episcleritis,Diseases of the Eye +Systemic sclerosis,Musculoskeletal conditions +Scoliosis,Musculoskeletal conditions +Seborrheic dermatitis,Skin conditions +Secondary Malignancy_Adrenal gland,Cancers +Secondary Malignancy_Bone,Cancers +Secondary Malignancy_Bowel,Cancers +"Secondary Malignancy_Brain, Other CNS and Intracranial",Cancers +Secondary malignancy_Liver and intrahepatic bile duct,Cancers +Secondary Malignancy_Lung,Cancers +Secondary Malignancy_Lymph Nodes,Cancers +Secondary Malignancy_Other organs,Cancers +Secondary Malignancy_retroperitoneum and peritoneum,Cancers +Secondary Malignancy_Pleura,Cancers +Secondary polycythaemia,Haematological/Immunological conditions +Secondary pulmonary hypertension,Diseases of the Circulatory System +Secondary or other Thrombocytopaenia,Haematological/Immunological conditions +Bacterial sepsis of newborn,Perinatal conditions +Septicaemia,Infectious Diseases +Sick sinus syndrome,Diseases of the Circulatory System +Sickle-cell anaemia,Haematological/Immunological conditions +Sickle-cell trait,Haematological/Immunological conditions +Sjogren's disease,Musculoskeletal conditions +Sleep apnoea,Diseases of the Respiratory System +Spina bifida,Perinatal conditions +Spinal stenosis,Musculoskeletal conditions +Spondylolisthesis,Musculoskeletal conditions +Spondylosis,Musculoskeletal conditions +Stable angina,Diseases of the Circulatory System +Stroke NOS,Diseases of the Circulatory System +Subarachnoid haemorrhage,Diseases of the Circulatory System +Subdural haematoma - nontraumatic,Diseases of the Circulatory System +Other psychoactive substance misuse,Mental Health Disorders +Supraventricular tachycardia,Diseases of the Circulatory System +Syndrome of inappropriate secretion of antidiuretic hormone,Diseases of the Endocrine System +Thalassaemia,Haematological/Immunological conditions +Thalassaemia trait,Haematological/Immunological conditions +Thrombophilia,Haematological/Immunological conditions +Hypo or hyperthyroidism,Diseases of the Endocrine System +Tinnitus,Diseases of the Ear +Transient ischaemic attack,Diseases of the Circulatory System +Trifascicular block,Diseases of the Circulatory System +Trigeminal neuralgia,Neurological conditions +Tuberculosis,Infectious Diseases +Tubulo-interstitial nephritis,Diseases of the Genitourinary system +,Diseases of the Endocrine System +,Diseases of the Endocrine System +Ulcerative colitis,Diseases of the Digestive System +Undescended testicle,Diseases of the Genitourinary system +Unstable Angina,Diseases of the Circulatory System +Urinary Incontinence,Diseases of the Genitourinary system +Urinary Tract Infections,Infectious Diseases +Urolithiasis,Diseases of the Genitourinary system +Urticaria,Skin conditions +Female genital prolapse,Diseases of the Genitourinary system +Venous thromboembolic disease (Excl PE),Diseases of the Circulatory System +Ventricular tachycardia,Diseases of the Circulatory System +Viral diseases (excl chronic hepatitis/HIV),Infectious Diseases +Vitamin B12 deficiency anaemia,Haematological/Immunological conditions +Vitiligo,Skin conditions +Volvulus,Diseases of the Digestive System \ No newline at end of file