diff --git a/spring-integration-core/src/main/java/org/springframework/integration/handler/support/MessagingMethodInvokerHelper.java b/spring-integration-core/src/main/java/org/springframework/integration/handler/support/MessagingMethodInvokerHelper.java
index df40a24f964..94616b3b783 100644
--- a/spring-integration-core/src/main/java/org/springframework/integration/handler/support/MessagingMethodInvokerHelper.java
+++ b/spring-integration-core/src/main/java/org/springframework/integration/handler/support/MessagingMethodInvokerHelper.java
@@ -576,6 +576,7 @@ private void configureLocalMessageHandlerFactory() {
 		localHandlerMethodFactory.afterPropertiesSet();
 	}
 
+	@Nullable
 	private Object invokeHandlerMethod(HandlerMethod handlerMethod, ParametersWrapper parameters) {
 		try {
 			return handlerMethod.invoke(parameters);
@@ -1093,13 +1094,20 @@ void setInvocableHandlerMethod(InvocableHandlerMethod newInvocableHandlerMethod)
 			this.invocableHandlerMethod = newInvocableHandlerMethod;
 		}
 
+		@Nullable
 		public Object invoke(ParametersWrapper parameters) {
 			Message<?> message = parameters.getMessage();
 			if (this.canProcessMessageList) {
 				message = new MutableMessage<>(parameters.getMessages(), parameters.getHeaders());
 			}
 			try {
-				return this.invocableHandlerMethod.invoke(message);
+				Object result = this.invocableHandlerMethod.invoke(message);
+				if (result != null
+						&& org.springframework.integration.util.ClassUtils.isKotlinUnit(result.getClass())) {
+
+					result = null;
+				}
+				return result;
 			}
 			catch (RuntimeException ex) { // NOSONAR no way to handle conditional catch according Sonar rules
 				throw ex;
diff --git a/spring-integration-core/src/main/java/org/springframework/integration/util/ClassUtils.java b/spring-integration-core/src/main/java/org/springframework/integration/util/ClassUtils.java
index 8ac0609ab12..85dda3b0671 100644
--- a/spring-integration-core/src/main/java/org/springframework/integration/util/ClassUtils.java
+++ b/spring-integration-core/src/main/java/org/springframework/integration/util/ClassUtils.java
@@ -83,6 +83,11 @@ public abstract class ClassUtils {
 	 */
 	public static final Class<?> KOTLIN_FUNCTION_1_CLASS;
 
+	/**
+	 * The {@code kotlin.Unit} class object.
+	 */
+	public static final Class<?> KOTLIN_UNIT_CLASS;
+
 	static {
 		PRIMITIVE_WRAPPER_TYPE_MAP.put(Boolean.class, boolean.class);
 		PRIMITIVE_WRAPPER_TYPE_MAP.put(Byte.class, byte.class);
@@ -161,6 +166,18 @@ public abstract class ClassUtils {
 		finally {
 			KOTLIN_FUNCTION_1_CLASS = kotlinClass;
 		}
+
+		kotlinClass = null;
+		try {
+			kotlinClass = org.springframework.util.ClassUtils.forName("kotlin.Unit",
+					org.springframework.util.ClassUtils.getDefaultClassLoader());
+		}
+		catch (ClassNotFoundException e) {
+			//Ignore: assume no Kotlin in classpath
+		}
+		finally {
+			KOTLIN_UNIT_CLASS = kotlinClass;
+		}
 	}
 
 	public static Class<?> findClosestMatch(Class<?> type, Set<Class<?>> candidates, boolean failOnTie) {
@@ -247,4 +264,14 @@ public static boolean isKotlinFaction1(Class<?> aClass) {
 		return KOTLIN_FUNCTION_1_CLASS != null && KOTLIN_FUNCTION_1_CLASS.isAssignableFrom(aClass);
 	}
 
+	/**
+	 * Check if class is {@code kotlin.Unit}.
+	 * @param aClass the {@link Class} to check.
+	 * @return true if class is a {@code kotlin.Unit} implementation.
+	 * @since 5.3.2
+	 */
+	public static boolean isKotlinUnit(Class<?> aClass) {
+		return KOTLIN_UNIT_CLASS != null && KOTLIN_UNIT_CLASS.isAssignableFrom(aClass);
+	}
+
 }
diff --git a/spring-integration-core/src/test/kotlin/org/springframework/integration/dsl/KotlinDslTests.kt b/spring-integration-core/src/test/kotlin/org/springframework/integration/dsl/KotlinDslTests.kt
index 91b1ed10c67..3bf29a29e2f 100644
--- a/spring-integration-core/src/test/kotlin/org/springframework/integration/dsl/KotlinDslTests.kt
+++ b/spring-integration-core/src/test/kotlin/org/springframework/integration/dsl/KotlinDslTests.kt
@@ -17,12 +17,9 @@
 package org.springframework.integration.dsl
 
 import assertk.assertThat
-import assertk.assertions.isEqualTo
-import assertk.assertions.isGreaterThanOrEqualTo
-import assertk.assertions.isInstanceOf
-import assertk.assertions.isNotNull
-import assertk.assertions.isTrue
-import assertk.assertions.size
+import assertk.assertions.*
+import org.apache.commons.logging.Log
+import org.apache.commons.logging.LogFactory
 import org.junit.jupiter.api.Test
 import org.springframework.beans.factory.BeanFactory
 import org.springframework.beans.factory.annotation.Autowired
@@ -51,6 +48,7 @@ import org.springframework.test.context.junit.jupiter.SpringJUnitConfig
 import reactor.core.publisher.Flux
 import reactor.test.StepVerifier
 import java.util.*
+import java.util.concurrent.atomic.AtomicReference
 import java.util.function.Function
 
 /**
@@ -210,6 +208,23 @@ class KotlinDslTests {
 		assertThat(payload).isInstanceOf(List::class.java).size().isGreaterThanOrEqualTo(1)
 	}
 
+	@Test
+	fun `no reply from handle`() {
+		val payloadReference = AtomicReference<String>()
+		val integrationFlow =
+				integrationFlow("handlerInputChanenl") {
+					handle<String> { payload, _ ->  payloadReference.set(payload) }
+				}
+
+		val registration = this.integrationFlowContext.registration(integrationFlow).register()
+
+		registration.inputChannel.send(GenericMessage("test"))
+
+		assertThat(payloadReference.get()).isEqualTo("test")
+
+		registration.destroy()
+	}
+
 	@Configuration
 	@EnableIntegration
 	class Config {