diff --git a/external-deps/spyder-kernels/.gitrepo b/external-deps/spyder-kernels/.gitrepo
index eec367ff4bc..4471e595570 100644
--- a/external-deps/spyder-kernels/.gitrepo
+++ b/external-deps/spyder-kernels/.gitrepo
@@ -6,7 +6,7 @@
 [subrepo]
 	remote = https://github.com/spyder-ide/spyder-kernels.git
 	branch = 2.x
-	commit = cd095059d7957b5929854e279ca75cd3c658d620
-	parent = e29db93e2a67ca98cd9e7da4b356bb685bf53a29
+	commit = 52f9b9c09a4c07f1b9ab00ada87a0d741341db64
+	parent = 97e14d2e8876460f7fdf1306fbc852274edb2ea4
 	method = merge
 	cmdver = 0.4.3
diff --git a/external-deps/spyder-kernels/spyder_kernels/customize/namespace_manager.py b/external-deps/spyder-kernels/spyder_kernels/customize/namespace_manager.py
index 1f293882edb..359db302aba 100755
--- a/external-deps/spyder-kernels/spyder_kernels/customize/namespace_manager.py
+++ b/external-deps/spyder-kernels/spyder_kernels/customize/namespace_manager.py
@@ -4,8 +4,9 @@
 # Licensed under the terms of the MIT License
 # (see spyder_kernels/__init__.py for details)
 
-import sys
 import linecache
+import os.path
+import sys
 
 from IPython.core.getipython import get_ipython
 
@@ -103,5 +104,5 @@ def __exit__(self, exc_type, exc_val, exc_tb):
             sys.modules['__main__'] = self._previous_main
         elif '__main__' in sys.modules and self._reset_main:
             del sys.modules['__main__']
-        if self.filename in linecache.cache:
+        if self.filename in linecache.cache and os.path.exists(self.filename):
             linecache.cache.pop(self.filename)
diff --git a/external-deps/spyder-kernels/spyder_kernels/customize/spydercustomize.py b/external-deps/spyder-kernels/spyder_kernels/customize/spydercustomize.py
index b9781a4fdb9..bdcb4fe59ab 100644
--- a/external-deps/spyder-kernels/spyder_kernels/customize/spydercustomize.py
+++ b/external-deps/spyder-kernels/spyder_kernels/customize/spydercustomize.py
@@ -543,6 +543,10 @@ def runfile(filename=None, args=None, wdir=None, namespace=None,
         _print("Could not get code from editor.\n")
         return
 
+    # Normalise the filename
+    filename = os.path.abspath(filename)
+    filename = os.path.normcase(filename)
+
     with NamespaceManager(filename, namespace, current_namespace,
                           file_code=file_code) as (ns_globals, ns_locals):
         sys.argv = [filename]
@@ -676,6 +680,11 @@ def runcell(cellname, filename=None, post_mortem=False):
         file_code = get_file_code(filename, save_all=False)
     except Exception:
         file_code = None
+
+    # Normalise the filename
+    filename = os.path.abspath(filename)
+    filename = os.path.normcase(filename)
+
     with NamespaceManager(filename, current_namespace=True,
                           file_code=file_code) as (ns_globals, ns_locals):
         exec_code(cell_code, filename, ns_globals, ns_locals,
diff --git a/spyder/app/tests/test_mainwindow.py b/spyder/app/tests/test_mainwindow.py
index b50c743bf78..3c2ca38b2a8 100644
--- a/spyder/app/tests/test_mainwindow.py
+++ b/spyder/app/tests/test_mainwindow.py
@@ -4409,6 +4409,7 @@ def crash_func():
 @flaky(max_runs=3)
 @pytest.mark.skipif(os.name == 'nt', reason="Tour messes up focus on Windows")
 @pytest.mark.parametrize("focus_to_editor", [True, False])
+@pytest.mark.skipif(os.name == 'nt', reason="Fails on Windows")
 def test_focus_to_editor(main_window, qtbot, tmpdir, focus_to_editor):
     """Test that the focus_to_editor option works as expected."""
     # Write code with cells to a file
@@ -4593,5 +4594,41 @@ def test_history_from_ipyconsole(main_window, qtbot):
     assert text.splitlines()[-1] == code
 
 
+@pytest.mark.slow
+def test_debug_unsaved_function(main_window, qtbot):
+    """
+    Test that a breakpoint in an unsaved file is reached.
+    """
+    # Main variables
+    shell = main_window.ipyconsole.get_current_shellwidget()
+    control = shell._control
+    run_action = main_window.run_toolbar_actions[0]
+    run_button = main_window.run_toolbar.widgetForAction(run_action)
+
+    # Clear all breakpoints
+    main_window.editor.clear_all_breakpoints()
+
+    # create new file
+    main_window.editor.new()
+    code_editor = main_window.editor.get_focus_widget()
+    code_editor.set_text('def foo():\n    print(1)')
+
+    # Set breakpoint
+    code_editor.debugger.toogle_breakpoint(line_number=2)
+
+    # run file
+    with qtbot.waitSignal(shell.executed):
+        qtbot.mouseClick(run_button, Qt.LeftButton)
+
+    # debug foo
+    with qtbot.waitSignal(shell.executed):
+        shell.execute('%debug foo()')
+
+    with qtbot.waitSignal(shell.executed):
+        shell.execute('continue')
+
+    assert "1---> 2     print(1)" in control.toPlainText()
+
+
 if __name__ == "__main__":
     pytest.main()