diff --git a/docs/configuration.md b/docs/configuration.md
index 0cc13d288d..b1965eec73 100644
--- a/docs/configuration.md
+++ b/docs/configuration.md
@@ -138,7 +138,7 @@ Config file: `"ignorePatterns": ["dist", "coverage"]`<br />
 
 Specify the patterns to all files or directories that are not used to run your tests and thus should _not be copied_ to the sandbox directory for mutation testing. Each patterns in this array should be a [`.gitignore`-style glob pattern](https://git-scm.com/docs/gitignore#_pattern_format). 
 
-These patterns are **always ignored**: `['node_modules', '.git', '/reports', '/stryker.log', '.stryker-tmp']`. Because Stryker always ignores these, you should rarely have to adjust the `"ignorePatterns"` setting at all. If you want to undo one of these ignore patterns, you can use the `!` prefix, for example: `['!node_modules']`.
+These patterns are **always ignored**: `['node_modules', '.git', '/reports' '*.tsbuildinfo', '/stryker.log', '.stryker-tmp']`. Because Stryker always ignores these, you should rarely have to adjust the `"ignorePatterns"` setting at all. If you want to undo one of these ignore patterns, you can use the `!` prefix, for example: `['!node_modules']`.
 
 If a glob pattern starts with `/`, the pattern is relative to the current working directory. For example, `/foo.js` matches to `foo.js` but not `subdir/foo.js`.
 
diff --git a/packages/core/src/input/input-file-resolver.ts b/packages/core/src/input/input-file-resolver.ts
index 61d3acb43b..674d14a11a 100644
--- a/packages/core/src/input/input-file-resolver.ts
+++ b/packages/core/src/input/input-file-resolver.ts
@@ -28,7 +28,7 @@ function toReportSourceFile(file: File): SourceFile {
   };
 }
 
-const ALWAYS_IGNORE = Object.freeze(['node_modules', '.git', '/reports', '/stryker.log']);
+const ALWAYS_IGNORE = Object.freeze(['node_modules', '.git', '/reports', '*.tsbuildinfo', '/stryker.log']);
 
 export const IGNORE_PATTERN_CHARACTER = '!';
 export const MUTATION_RANGE_REGEX = /(.*?):((\d+)(?::(\d+))?-(\d+)(?::(\d+))?)$/;
diff --git a/packages/core/test/unit/input/input-file-resolver.spec.ts b/packages/core/test/unit/input/input-file-resolver.spec.ts
index 7d213c85cf..9fe9fe7b7a 100644
--- a/packages/core/test/unit/input/input-file-resolver.spec.ts
+++ b/packages/core/test/unit/input/input-file-resolver.spec.ts
@@ -29,7 +29,7 @@ describe(InputFileResolver.name, () => {
     const sut = createSut();
     await sut.resolve();
     expect(testInjector.logger.warn).calledWith(
-      `No files found in directory ${process.cwd()} using ignore rules: ["node_modules",".git","/reports","/stryker.log",".stryker-tmp"]. Make sure you run Stryker from the root directory of your project with the correct "ignorePatterns".`
+      `No files found in directory ${process.cwd()} using ignore rules: ["node_modules",".git","/reports","*.tsbuildinfo","/stryker.log",".stryker-tmp"]. Make sure you run Stryker from the root directory of your project with the correct "ignorePatterns".`
     );
   });
 
@@ -90,7 +90,7 @@ describe(InputFileResolver.name, () => {
       expect(files[0].name).eq(path.resolve('packages', 'app', 'src', 'index.js'));
     });
 
-    it('should ignore node_modules, .git, reports, stryker.log and .stryker-tmp by default', async () => {
+    it('should ignore node_modules, .git, reports, stryker.log, *.tsbuildinfo and .stryker-tmp by default', async () => {
       // Arrange
       stubFileSystem({
         '.git': { config: '' },
@@ -98,6 +98,10 @@ describe(InputFileResolver.name, () => {
         '.stryker-tmp': { 'stryker-sandbox-123': { src: { 'index.js': '' } } },
         'index.js': '',
         'stryker.log': '',
+        'tsconfig.src.tsbuildinfo': '',
+        dist: {
+          'tsconfig.tsbuildinfo': '',
+        },
         reports: { mutation: { 'mutation.json': '' } },
       });
       const sut = createSut();