diff --git a/packages/protocol/script/SetupUSDCBridging.s.sol b/packages/protocol/script/SetupUSDCBridging.s.sol
new file mode 100644
index 0000000000..d04b79d866
--- /dev/null
+++ b/packages/protocol/script/SetupUSDCBridging.s.sol
@@ -0,0 +1,55 @@
+// SPDX-License-Identifier: MIT
+pragma solidity 0.8.24;
+
+import "../test/DeployCapability.sol";
+import "../contracts/tokenvault/ERC20Vault.sol";
+
+/// @dev This script shall be run on Taiko chain to hook up a native USDC deployment and the USDC
+/// deployed on layer 1.
+///
+/// To deploy a native USDC contract on L2, run:
+/// https://github.com/taikoxyz/USDC/blob/main/script/DeployUSDC.s.sol
+contract SetupUSDCBridging is DeployCapability {
+    address public constant USDC_ON_ETHEREUM = 0xA0b86991c6218b36c1d19D4a2e9Eb0cE3606eB48;
+
+    uint256 public privateKey = vm.envUint("PRIVATE_KEY");
+    address public erc20VaultOnL2 = vm.envAddress("ERC20_VAULT_ON_L2");
+
+    // These are FiatTokenProxy addresses of the USDC coin.
+    address public usdcOnL1 = vm.envAddress("USDC_ADDRESS_ON_L1");
+    address public usdcOnL2 = vm.envAddress("USDC_ADDRESS_ON_L2");
+
+    function run() external {
+        require(erc20VaultOnL2 != address(0) && usdcOnL2 != address(0), "invalid params");
+
+        if (usdcOnL1 == address(0)) {
+            usdcOnL1 = USDC_ON_ETHEREUM;
+        }
+
+        ERC20Vault vault = ERC20Vault(erc20VaultOnL2);
+
+        address currBridgedtoken = vault.canonicalToBridged(1, usdcOnL1);
+        console2.log("current btoken for usdc:", currBridgedtoken);
+
+        vm.startBroadcast(privateKey);
+        vault.changeBridgedToken(
+            ERC20Vault.CanonicalERC20({
+                chainId: 1,
+                addr: usdcOnL1,
+                decimals: 6,
+                symbol: "USDC",
+                name: "USD Coin"
+            }),
+            usdcOnL2
+        );
+        if (vault.paused()) {
+            vault.unpause();
+        }
+        vm.stopBroadcast();
+
+        address newBridgedToken = vault.canonicalToBridged(1, usdcOnL1);
+        console2.log("new btoken for usdc:", newBridgedToken);
+
+        require(usdcOnL2 == newBridgedToken, "unexpected result");
+    }
+}