Could HiC-data be replaced by HiC-data generated by other comformation capture experiments like HiChIP or ChIA-PET?

[Gemma-Zhang-326]

Hi,

Dear author, the C.Origami is a beautiful job!

Could I replace the HiC experiment data with HiChIP or ChIA-PET data during training my model? As we all know, they are techniques that incorporate chromatin immunoprecipitation(ChIP)-based enrichment and chromatin proximity ligation, thus reflecting three-dimensional conformation data that capture specific chromatin modification. I wonder if your model can compatible with similar data.

Best wishes
Gemma

[tanjimin]

Hi Gemma,

Great question! I haven't try C.Origami on data other than Hi-C, but I think it should work the same.

Jimin

[Gemma-Zhang-326]

Thanks for the quick replay. Glad to know that. I will try it and let you know if it works. Thanks again!