diff --git a/.github/workflows/pythonpackage.yml b/.github/workflows/pythonpackage.yml
index fb26ecb0..187cd3d2 100644
--- a/.github/workflows/pythonpackage.yml
+++ b/.github/workflows/pythonpackage.yml
@@ -74,6 +74,7 @@ jobs:
         rm -rf ${TEMPLATEFLOW_HOME}/tpl-MNI152NLin2009cAsym
         source /tmp/install_sdist/bin/activate
         python -m pip install dist/templateflow*.tar.gz
+        python -c "import templateflow; templateflow.update(overwrite=False)"
         find ${TEMPLATEFLOW_HOME} >> /tmp/.sdist-install-2.txt
         diff /tmp/.sdist-install.txt /tmp/.sdist-install-2.txt
         exit $?
@@ -138,6 +139,7 @@ jobs:
         rm -rf ${TEMPLATEFLOW_HOME}/tpl-MNI152NLin2009cAsym
         source /tmp/setup_install/bin/activate
         python setup.py install
+        python -c "import templateflow; templateflow.update(overwrite=False)"
         find ${TEMPLATEFLOW_HOME} >> /tmp/.setup-install-2.txt
         diff /tmp/.setup-install.txt /tmp/.setup-install-2.txt
         exit $?
@@ -170,6 +172,7 @@ jobs:
         rm -rf ${TEMPLATEFLOW_HOME}/tpl-MNI152NLin2009cAsym
         source /tmp/setup_develop/bin/activate
         python setup.py develop
+        python -c "import templateflow; templateflow.update(overwrite=False)"
         find ${TEMPLATEFLOW_HOME} >> /tmp/.setup-develop-2.txt
         diff /tmp/.setup-develop.txt /tmp/.setup-develop-2.txt
         exit $?
diff --git a/setup.py b/setup.py
index dd0fa7cf..aeb5d8c8 100644
--- a/setup.py
+++ b/setup.py
@@ -2,8 +2,6 @@
 """Templateflow's setup script."""
 import sys
 from setuptools import setup
-from setuptools.command.install import install
-from setuptools.command.develop import develop
 
 
 # Give setuptools a hint to complain if it's too old a version
@@ -18,38 +16,9 @@
 # This enables setuptools to install wheel on-the-fly
 SETUP_REQUIRES += ["wheel"] if "bdist_wheel" in sys.argv else []
 
-
-def make_cmdclass(basecmd):
-    """Decorate setuptools commands."""
-    base_run = basecmd.run
-
-    def new_run(self):
-        from templateflow.conf import setup_home
-
-        setup_home()
-        base_run(self)
-
-    basecmd.run = new_run
-    return basecmd
-
-
-@make_cmdclass
-class CheckHomeDevCommand(develop):
-    """Setuptools command."""
-
-
-@make_cmdclass
-class CheckHomeProdCommand(install):
-    """Setuptools command."""
-
-
 if __name__ == "__main__":
     """ Install entry-point """
     setup(
         name="templateflow",
         setup_requires=SETUP_REQUIRES,
-        cmdclass={
-            "develop": CheckHomeDevCommand,
-            "install": CheckHomeProdCommand,
-        },
     )
diff --git a/templateflow/__init__.py b/templateflow/__init__.py
index ce02f9dc..a99c1cf6 100644
--- a/templateflow/__init__.py
+++ b/templateflow/__init__.py
@@ -14,8 +14,20 @@
     del get_distribution
     del DistributionNotFound
 
+import os
 from . import api
-from .conf import update
+from .conf import update, TF_USE_DATALAD
+
+
+if not TF_USE_DATALAD and os.getenv("TEMPLATEFLOW_AUTOUPDATE", "1") not in (
+    "false",
+    "off",
+    "0",
+    "no",
+    "n",
+):
+    # trigger skeleton autoupdate
+    update(local=True, overwrite=False, silent=True)
 
 __all__ = [
     '__copyright__',
diff --git a/templateflow/conf/__init__.py b/templateflow/conf/__init__.py
index 74a13617..f0ca9126 100644
--- a/templateflow/conf/__init__.py
+++ b/templateflow/conf/__init__.py
@@ -42,14 +42,14 @@
         _update_s3(TF_HOME, local=True, overwrite=True)
 
 
-def update(local=False, overwrite=True):
+def update(local=False, overwrite=True, silent=False):
     """Update an existing DataLad or S3 home."""
     if TF_USE_DATALAD and _update_datalad():
         return True
 
     from ._s3 import update as _update_s3
 
-    return _update_s3(TF_HOME, local=local, overwrite=overwrite)
+    return _update_s3(TF_HOME, local=local, overwrite=overwrite, silent=silent)
 
 
 def setup_home(force=False):
diff --git a/templateflow/conf/_s3.py b/templateflow/conf/_s3.py
index 2a76fed0..876c4500 100644
--- a/templateflow/conf/_s3.py
+++ b/templateflow/conf/_s3.py
@@ -13,11 +13,11 @@
 ).read_text()
 
 
-def update(dest, local=True, overwrite=True):
+def update(dest, local=True, overwrite=True, silent=False):
     """Update an S3-backed TEMPLATEFLOW_HOME repository."""
     skel_file = Path((_get_skeleton_file() if not local else None) or TF_SKEL_PATH)
 
-    retval = _update_skeleton(skel_file, dest, overwrite=overwrite)
+    retval = _update_skeleton(skel_file, dest, overwrite=overwrite, silent=silent)
     if skel_file != TF_SKEL_PATH:
         skel_file.unlink()
     return retval
@@ -45,7 +45,7 @@ def _get_skeleton_file():
             return skel_file
 
 
-def _update_skeleton(skel_file, dest, overwrite=True):
+def _update_skeleton(skel_file, dest, overwrite=True, silent=False):
     from zipfile import ZipFile
 
     dest = Path(dest)
@@ -62,11 +62,12 @@ def _update_skeleton(skel_file, dest, overwrite=True):
         ]
         newfiles = sorted(set(allfiles) - set(existing))
         if newfiles:
-            print(
-                "Updating TEMPLATEFLOW_HOME using S3. "
-                "Adding: \n%s" % "\n".join(newfiles)
-            )
+            if not silent:
+                print(
+                    "Updating TEMPLATEFLOW_HOME using S3. Adding:\n%s" % '\n'.join(newfiles)
+                )
             zipref.extractall(str(dest), members=newfiles)
             return True
-    print("TEMPLATEFLOW_HOME directory (S3 type) was up-to-date.")
+    if not silent:
+        print("TEMPLATEFLOW_HOME directory (S3 type) was up-to-date.")
     return False