diff --git a/tfjs-backend-wasm/package.json b/tfjs-backend-wasm/package.json
index 447508ef154..20bd899614f 100644
--- a/tfjs-backend-wasm/package.json
+++ b/tfjs-backend-wasm/package.json
@@ -36,7 +36,9 @@
   },
   "browser": {
     "fs": false,
-    "path": false
+    "path": false,
+    "worker_threads": false,
+    "perf_hooks": false
   },
   "peerDependencies": {
     "@tensorflow/tfjs-core": "link:../tfjs-core"
diff --git a/tfjs-backend-wasm/rollup.config.js b/tfjs-backend-wasm/rollup.config.js
index d29c4543639..6731490a483 100644
--- a/tfjs-backend-wasm/rollup.config.js
+++ b/tfjs-backend-wasm/rollup.config.js
@@ -61,10 +61,10 @@ function config({plugins = [], output = {}, tsCompilerOptions = {}}) {
     output: {
       banner: PREAMBLE,
       sourcemap: true,
-      globals: {'@tensorflow/tfjs-core': 'tf', 'fs': 'fs', 'path': 'path'},
+      globals: {'@tensorflow/tfjs-core': 'tf', 'fs': 'fs', 'path': 'path', 'worker_threads': 'worker_threads', 'perf_hooks': 'perf_hooks'},
       ...output,
     },
-    external: ['crypto', '@tensorflow/tfjs-core', 'fs', 'path'],
+    external: ['crypto', '@tensorflow/tfjs-core', 'fs', 'path', 'worker_threads', 'perf_hooks'],
     onwarn: warning => {
       let {code} = warning;
       if (code === 'CIRCULAR_DEPENDENCY' || code === 'CIRCULAR' ||
diff --git a/tfjs-backend-wasm/src/flags_wasm.ts b/tfjs-backend-wasm/src/flags_wasm.ts
index fb1bdeb50fe..c8f0f53c5e4 100644
--- a/tfjs-backend-wasm/src/flags_wasm.ts
+++ b/tfjs-backend-wasm/src/flags_wasm.ts
@@ -37,6 +37,12 @@ ENV.registerFlag(
  */
 // From: https://github.com/GoogleChromeLabs/wasm-feature-detect
 ENV.registerFlag('WASM_HAS_MULTITHREAD_SUPPORT', async () => {
+  // TODO(annxingyuan): Enable node support once this is resolved:
+  // https://github.com/tensorflow/tfjs/issues/3830
+  if (ENV.get('IS_NODE')) {
+    return false;
+  }
+
   try {
     // Test for transferability of SABs (needed for Firefox)
     // https://groups.google.com/forum/#!msg/mozilla.dev.platform/IHkBZlHETpA/dwsMNchWEQAJ