Make a Twitter bot and you can too
Or something like that.
After I made my first couple Twitter bots -- BotOrDeath repo and Friday repo -- I thought I might like a handy little template to make more. This is set up in Django to use Python to run Tweepy and store the tweets in a MySQL database. It's also done this way with the idea you might want to use a Django management command to run the bot on a server crontab -- but no worries if not. Just don't use that part.
Clone the repo, pip install from the reqs.txt file for the dependencies you'll need, and you're on your way.
For a more step-by-step approach as you work through this, check out this useful tutorial: http://videlais.com/2015/03/02/how-to-create-a-basic-twitterbot-in-python/
Happy tweeting and, y'know, try to be more funny than evil.