diff --git a/.github/workflows/macos-arm.yml b/.github/workflows/macos-arm.yml
new file mode 100644
index 00000000000..1a306793d60
--- /dev/null
+++ b/.github/workflows/macos-arm.yml
@@ -0,0 +1,86 @@
+name: ITK.macOS.Arm64
+
+on:
+    push:
+        branches:
+            - master
+            - 'release*'
+        paths-ignore:
+            - '*.md'
+            - LICENSE
+            - NOTICE
+            - 'Documentation/**'
+            - 'Utilities/Debugger/**'
+            - 'Utilities/ITKv5Preparation/**'
+            - 'Utilities/Maintenance/**'
+    pull_request:
+        paths-ignore:
+            - '*.md'
+            - LICENSE
+            - NOTICE
+            - 'Documentation/**'
+            - 'Utilities/Debugger/**'
+            - 'Utilities/ITKv5Preparation/**'
+            - 'Utilities/Maintenance/**'
+
+env:
+    ExternalDataVersion: 5.3.0
+
+jobs:
+    macOS:
+        runs-on: macos-14
+        timeout-minutes: 0
+        steps:
+            - name: Checkout
+              uses: actions/checkout@v4
+              with:
+                fetch-depth: 5
+                clean: true
+
+            - name: Set up Python
+              uses: actions/setup-python@v4
+              with:
+                  python-version: '3.11'
+
+            - name: Install dependencies
+              run: |
+                set -x
+                python3 -m pip install ninja
+                python3 -m pip install --upgrade setuptools
+                python3 -m pip install scikit-ci-addons
+                python3 -m pip install lxml
+
+            - name: Download dashboard script and testing data
+              run: |
+                set -x
+                git clone -b dashboard --single-branch https://github.com/InsightSoftwareConsortium/ITK.git ITK-dashboard
+
+                curl -L https://github.com/InsightSoftwareConsortium/ITK/releases/download/v${{ env.ExternalDataVersion }}/InsightData-${{ env.ExternalDataVersion }}.tar.gz -O
+                cmake -E tar xfz InsightData-${{ env.ExternalDataVersion }}.tar.gz
+                cmake -E rename InsightToolkit-${{ env.ExternalDataVersion }}/.ExternalData/MD5 ${{ github.workspace }}/.ExternalData/MD5
+
+            - name: Configure CTest script
+              run: |
+                cat > ITK-dashboard/dashboard.cmake << EOF
+                set(CTEST_BUILD_CONFIGURATION "Release")
+                set(CTEST_CMAKE_GENERATOR "Ninja")
+                set(dashboard_cache "
+                    BUILD_SHARED_LIBS:BOOL=ON
+                    BUILD_EXAMPLES:BOOL=ON
+                    ITK_WRAP_PYTHON:BOOL=OFF
+                    ITK_USE_CLANG_FORMAT:BOOL=OFF
+                ")
+                include(${{ github.workspace }}/ITK-dashboard/github_actions_dashboard.cmake)
+                EOF
+                cat ITK-dashboard/dashboard.cmake
+
+            - name: Build and test
+              run: |
+                set -x
+
+                c++ --version
+                cmake --version
+
+                ctest -S ${{ github.workspace }}/ITK-dashboard/dashboard.cmake -VV -j 4
+              env:
+                CTEST_OUTPUT_ON_FAILURE: 1
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