diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 580c449f2..e8f4acd4e 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -33,7 +33,6 @@ jobs:
           - rails_6_0
           - rails_5_2
           - rails_5_1
-          - rails_5_0
         adapter:
           - sqlite3
           - postgresql
diff --git a/Appraisals b/Appraisals
index 53a4418af..a410a7946 100644
--- a/Appraisals
+++ b/Appraisals
@@ -23,25 +23,6 @@ shared_dependencies = proc do
   instance_eval(&shared_test_dependencies)
 end
 
-appraise 'rails_5_0' do
-  instance_eval(&shared_dependencies)
-  instance_eval(&controller_test_dependency)
-
-  gem 'rails', '5.0.7.2'
-  gem 'puma', '~> 3.0'
-  gem 'sass-rails', '~> 5.0'
-  gem 'jquery-rails'
-  gem 'turbolinks', '~> 5'
-  gem 'jbuilder', '~> 2.5'
-  gem 'bcrypt', '~> 3.1.7'
-  gem 'listen', '~> 3.0.5'
-  gem 'spring-watcher-listen', '~> 2.0.0'
-
-  # Database adapters
-  gem 'pg', '~> 0.18'
-  gem 'sqlite3', '~> 1.3.6'
-end
-
 appraise 'rails_5_1' do
   instance_eval(&shared_dependencies)
   instance_eval(&controller_test_dependency)
diff --git a/README.md b/README.md
index 17bf50a3e..4f6f5c3e4 100644
--- a/README.md
+++ b/README.md
@@ -469,7 +469,7 @@ machine, understanding the codebase, and creating a good pull request.
 ## Compatibility
 
 Shoulda Matchers is tested and supported against Ruby 2.6+, Rails
-5.0+, RSpec 3.x, and Minitest 5.x.
+5.1+, RSpec 3.x, and Minitest 5.x.
 
 - For Ruby < 2.4 and Rails < 4.1 compatibility, please use [v3.1.3][v3.1.3].
 - For Ruby < 3.0 and Rails < 6.1 compatibility, please use [v4.5.1][v4.5.1].
diff --git a/gemfiles/rails_5_0.gemfile b/gemfiles/rails_5_0.gemfile
deleted file mode 100644
index e8f320c1d..000000000
--- a/gemfiles/rails_5_0.gemfile
+++ /dev/null
@@ -1,35 +0,0 @@
-# This file was generated by Appraisal
-
-source "https://rubygems.org"
-
-gem "appraisal", "2.2.0"
-gem "bundler", "~> 1.1"
-gem "pry"
-gem "pry-byebug"
-gem "rake", "13.0.1"
-gem "rspec", "~> 3.9"
-gem "rubocop", require: false
-gem "rubocop-packaging", require: false
-gem "rubocop-rails", require: false
-gem "warnings_logger"
-gem "zeus", require: false
-gem "fssm"
-gem "redcarpet"
-gem "rouge"
-gem "yard"
-gem "spring"
-gem "spring-commands-rspec"
-gem "rspec-rails", "~> 4.0"
-gem "shoulda-context", "~> 1.2.0"
-gem "rails-controller-testing", ">= 1.0.1"
-gem "rails", "5.0.7.2"
-gem "puma", "~> 3.0"
-gem "sass-rails", "~> 5.0"
-gem "jquery-rails"
-gem "turbolinks", "~> 5"
-gem "jbuilder", "~> 2.5"
-gem "bcrypt", "~> 3.1.7"
-gem "listen", "~> 3.0.5"
-gem "spring-watcher-listen", "~> 2.0.0"
-gem "pg", "~> 0.18"
-gem "sqlite3", "~> 1.3.6"
diff --git a/gemfiles/rails_5_0.gemfile.lock b/gemfiles/rails_5_0.gemfile.lock
deleted file mode 100644
index 23f9b4899..000000000
--- a/gemfiles/rails_5_0.gemfile.lock
+++ /dev/null
@@ -1,253 +0,0 @@
-GEM
-  remote: https://rubygems.org/
-  specs:
-    actioncable (5.0.7.2)
-      actionpack (= 5.0.7.2)
-      nio4r (>= 1.2, < 3.0)
-      websocket-driver (~> 0.6.1)
-    actionmailer (5.0.7.2)
-      actionpack (= 5.0.7.2)
-      actionview (= 5.0.7.2)
-      activejob (= 5.0.7.2)
-      mail (~> 2.5, >= 2.5.4)
-      rails-dom-testing (~> 2.0)
-    actionpack (5.0.7.2)
-      actionview (= 5.0.7.2)
-      activesupport (= 5.0.7.2)
-      rack (~> 2.0)
-      rack-test (~> 0.6.3)
-      rails-dom-testing (~> 2.0)
-      rails-html-sanitizer (~> 1.0, >= 1.0.2)
-    actionview (5.0.7.2)
-      activesupport (= 5.0.7.2)
-      builder (~> 3.1)
-      erubis (~> 2.7.0)
-      rails-dom-testing (~> 2.0)
-      rails-html-sanitizer (~> 1.0, >= 1.0.3)
-    activejob (5.0.7.2)
-      activesupport (= 5.0.7.2)
-      globalid (>= 0.3.6)
-    activemodel (5.0.7.2)
-      activesupport (= 5.0.7.2)
-    activerecord (5.0.7.2)
-      activemodel (= 5.0.7.2)
-      activesupport (= 5.0.7.2)
-      arel (~> 7.0)
-    activesupport (5.0.7.2)
-      concurrent-ruby (~> 1.0, >= 1.0.2)
-      i18n (>= 0.7, < 2)
-      minitest (~> 5.1)
-      tzinfo (~> 1.1)
-    appraisal (2.2.0)
-      bundler
-      rake
-      thor (>= 0.14.0)
-    arel (7.1.4)
-    ast (2.4.2)
-    bcrypt (3.1.16)
-    builder (3.2.4)
-    byebug (11.1.3)
-    coderay (1.1.3)
-    concurrent-ruby (1.1.8)
-    crass (1.0.6)
-    diff-lcs (1.4.4)
-    erubis (2.7.0)
-    ffi (1.14.2)
-    fssm (0.2.10)
-    globalid (0.4.2)
-      activesupport (>= 4.2.0)
-    i18n (1.8.9)
-      concurrent-ruby (~> 1.0)
-    jbuilder (2.11.2)
-      activesupport (>= 5.0.0)
-    jquery-rails (4.4.0)
-      rails-dom-testing (>= 1, < 3)
-      railties (>= 4.2.0)
-      thor (>= 0.14, < 2.0)
-    listen (3.0.8)
-      rb-fsevent (~> 0.9, >= 0.9.4)
-      rb-inotify (~> 0.9, >= 0.9.7)
-    loofah (2.9.0)
-      crass (~> 1.0.2)
-      nokogiri (>= 1.5.9)
-    mail (2.7.1)
-      mini_mime (>= 0.1.1)
-    method_source (1.0.0)
-    mini_mime (1.0.2)
-    mini_portile2 (2.5.0)
-    minitest (5.14.4)
-    nio4r (2.5.5)
-    nokogiri (1.11.1)
-      mini_portile2 (~> 2.5.0)
-      racc (~> 1.4)
-    parallel (1.20.1)
-    parser (3.0.0.0)
-      ast (~> 2.4.1)
-    pg (0.21.0)
-    pry (0.13.1)
-      coderay (~> 1.1)
-      method_source (~> 1.0)
-    pry-byebug (3.9.0)
-      byebug (~> 11.0)
-      pry (~> 0.13.0)
-    puma (3.12.6)
-    racc (1.5.2)
-    rack (2.2.3)
-    rack-test (0.6.3)
-      rack (>= 1.0)
-    rails (5.0.7.2)
-      actioncable (= 5.0.7.2)
-      actionmailer (= 5.0.7.2)
-      actionpack (= 5.0.7.2)
-      actionview (= 5.0.7.2)
-      activejob (= 5.0.7.2)
-      activemodel (= 5.0.7.2)
-      activerecord (= 5.0.7.2)
-      activesupport (= 5.0.7.2)
-      bundler (>= 1.3.0)
-      railties (= 5.0.7.2)
-      sprockets-rails (>= 2.0.0)
-    rails-controller-testing (1.0.5)
-      actionpack (>= 5.0.1.rc1)
-      actionview (>= 5.0.1.rc1)
-      activesupport (>= 5.0.1.rc1)
-    rails-dom-testing (2.0.3)
-      activesupport (>= 4.2.0)
-      nokogiri (>= 1.6)
-    rails-html-sanitizer (1.3.0)
-      loofah (~> 2.3)
-    railties (5.0.7.2)
-      actionpack (= 5.0.7.2)
-      activesupport (= 5.0.7.2)
-      method_source
-      rake (>= 0.8.7)
-      thor (>= 0.18.1, < 2.0)
-    rainbow (3.0.0)
-    rake (13.0.1)
-    rb-fsevent (0.10.4)
-    rb-inotify (0.10.1)
-      ffi (~> 1.0)
-    redcarpet (3.5.1)
-    regexp_parser (2.1.1)
-    rexml (3.2.4)
-    rouge (3.26.0)
-    rspec (3.10.0)
-      rspec-core (~> 3.10.0)
-      rspec-expectations (~> 3.10.0)
-      rspec-mocks (~> 3.10.0)
-    rspec-core (3.10.1)
-      rspec-support (~> 3.10.0)
-    rspec-expectations (3.10.1)
-      diff-lcs (>= 1.2.0, < 2.0)
-      rspec-support (~> 3.10.0)
-    rspec-mocks (3.10.2)
-      diff-lcs (>= 1.2.0, < 2.0)
-      rspec-support (~> 3.10.0)
-    rspec-rails (4.0.2)
-      actionpack (>= 4.2)
-      activesupport (>= 4.2)
-      railties (>= 4.2)
-      rspec-core (~> 3.10)
-      rspec-expectations (~> 3.10)
-      rspec-mocks (~> 3.10)
-      rspec-support (~> 3.10)
-    rspec-support (3.10.2)
-    rubocop (1.10.0)
-      parallel (~> 1.10)
-      parser (>= 3.0.0.0)
-      rainbow (>= 2.2.2, < 4.0)
-      regexp_parser (>= 1.8, < 3.0)
-      rexml
-      rubocop-ast (>= 1.2.0, < 2.0)
-      ruby-progressbar (~> 1.7)
-      unicode-display_width (>= 1.4.0, < 3.0)
-    rubocop-ast (1.4.1)
-      parser (>= 2.7.1.5)
-    rubocop-packaging (0.5.1)
-      rubocop (>= 0.89, < 2.0)
-    rubocop-rails (2.9.1)
-      activesupport (>= 4.2.0)
-      rack (>= 1.1)
-      rubocop (>= 0.90.0, < 2.0)
-    ruby-progressbar (1.11.0)
-    sass (3.7.4)
-      sass-listen (~> 4.0.0)
-    sass-listen (4.0.0)
-      rb-fsevent (~> 0.9, >= 0.9.4)
-      rb-inotify (~> 0.9, >= 0.9.7)
-    sass-rails (5.0.7)
-      railties (>= 4.0.0, < 6)
-      sass (~> 3.1)
-      sprockets (>= 2.8, < 4.0)
-      sprockets-rails (>= 2.0, < 4.0)
-      tilt (>= 1.1, < 3)
-    shoulda-context (1.2.2)
-    spring (2.1.1)
-    spring-commands-rspec (1.0.4)
-      spring (>= 0.9.1)
-    spring-watcher-listen (2.0.1)
-      listen (>= 2.7, < 4.0)
-      spring (>= 1.2, < 3.0)
-    sprockets (3.7.2)
-      concurrent-ruby (~> 1.0)
-      rack (> 1, < 3)
-    sprockets-rails (3.2.2)
-      actionpack (>= 4.0)
-      activesupport (>= 4.0)
-      sprockets (>= 3.0.0)
-    sqlite3 (1.3.13)
-    thor (1.1.0)
-    thread_safe (0.3.6)
-    tilt (2.0.10)
-    turbolinks (5.2.1)
-      turbolinks-source (~> 5.2)
-    turbolinks-source (5.2.0)
-    tzinfo (1.2.9)
-      thread_safe (~> 0.1)
-    unicode-display_width (2.0.0)
-    warnings_logger (0.1.1)
-    websocket-driver (0.6.5)
-      websocket-extensions (>= 0.1.0)
-    websocket-extensions (0.1.5)
-    yard (0.9.26)
-    zeus (0.15.14)
-      method_source (>= 0.6.7)
-
-PLATFORMS
-  ruby
-
-DEPENDENCIES
-  appraisal (= 2.2.0)
-  bcrypt (~> 3.1.7)
-  bundler (~> 1.1)
-  fssm
-  jbuilder (~> 2.5)
-  jquery-rails
-  listen (~> 3.0.5)
-  pg (~> 0.18)
-  pry
-  pry-byebug
-  puma (~> 3.0)
-  rails (= 5.0.7.2)
-  rails-controller-testing (>= 1.0.1)
-  rake (= 13.0.1)
-  redcarpet
-  rouge
-  rspec (~> 3.9)
-  rspec-rails (~> 4.0)
-  rubocop
-  rubocop-packaging
-  rubocop-rails
-  sass-rails (~> 5.0)
-  shoulda-context (~> 1.2.0)
-  spring
-  spring-commands-rspec
-  spring-watcher-listen (~> 2.0.0)
-  sqlite3 (~> 1.3.6)
-  turbolinks (~> 5)
-  warnings_logger
-  yard
-  zeus
-
-BUNDLED WITH
-   1.17.3
diff --git a/shoulda-matchers.gemspec b/shoulda-matchers.gemspec
index 01bc13b04..b9203ed28 100644
--- a/shoulda-matchers.gemspec
+++ b/shoulda-matchers.gemspec
@@ -37,5 +37,5 @@ Gem::Specification.new do |s|
   s.require_paths = ['lib']
 
   s.required_ruby_version = '>= 2.6.0'
-  s.add_dependency('activesupport', '>= 5.0.0')
+  s.add_dependency('activesupport', '>= 5.1.0')
 end