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Pooled CRISPR screen optimization tool
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README.md

CRISPulator

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A pooled genetic screen simulator

Crispulator does not yet support Julia 1.0! We're still waiting on all the dependencies to be updated, please use Julia v0.6.4 in the mean time.

Motivation

Pooled screens are very useful, but they are also extraordinarily complex. This work aims to explore the importance of various screen parameters and the relevance of design choices on the downstream analysis and interpretation.

Paper

Nagy, T. & Kampmann, M. CRISPulator: a discrete simulation tool for pooled genetic screens. BMC Bioinformatics 18, 347 (2017). https://doi.org/10.1186/s12859-017-1759-9 (Preprint also available)

Documentation

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