This is the living database of lipidomic aberrations during the pathogenesis of type 1 diabetes (T1D).
The database has been collected from scientific publications that report abnormalities related to the onset of T1D. In practice, this either means:
- lipids that are aberrated in blood samples collected from persons, who are later known to have been diagnosed with T1D,
- lipids that are aberrated in blood samples collected from persons, who are have islet auto-antibodies (IAA-positive), or
- lipids that are associated with the deterioration of insulin secretion in blood samples collected from persons recently diagnosed with T1D.
This database is described in the following publication. Please cite the publication, if you use the database or related code:
Tommi Suvitaival. Lipidomic Abnormalities During the Pathogenesis of Type 1 Diabetes: a Quantitative Review. Current Diabetes Reports. 20, 46 (2020). http://dx.doi.org/10.1007/s11892-020-01326-8
The database that was used in the publication was collected from eight scientific publications.
- The database can be found at data/T1D-lipidome-database.tsv.
- The analysis code along with output can be found at the scripts folder.
The database is also being updated, when new publications appear in the field.
- The updated database can be found at data-updated/T1D-lipidome-database-updated.tsv.
- The analysis code along with updated output can be found at the scripts-updated folder.
If you know of a new publication in the field and the publication reports direct lipid-specific associtions to the onset or progression of T1D, you are welcome to inform the author of the database, Tommi Suvitaival, about it. Most easily, this can be done by posting an issue to this Github repository or, alternatively, via email.
This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 115797 (INNODIA). This Joint Undertaking receives support from the Union’s Horizon 2020 research and innovation programme and “EFPIA”, ‘JDRF” and “The Leona M. and Harry B. Helmsley Charitable Trust”.