diff --git a/docs/changelog/1380.bugfix.rst b/docs/changelog/1380.bugfix.rst
new file mode 100644
index 000000000..c7fdadf16
--- /dev/null
+++ b/docs/changelog/1380.bugfix.rst
@@ -0,0 +1 @@
+Honor environment markers in ``requires`` list - by :user:`asottile`
diff --git a/src/tox/config/__init__.py b/src/tox/config/__init__.py
index b5df35833..1d66ed7ae 100644
--- a/src/tox/config/__init__.py
+++ b/src/tox/config/__init__.py
@@ -1165,6 +1165,9 @@ def ensure_requires_satisfied(config, requires, min_version):
             # noinspection PyBroadException
             try:
                 package = requirements.Requirement(require)
+                # check if the package even applies
+                if package.marker and not package.marker.evaluate({"extra": ""}):
+                    continue
                 package_name = canonicalize_name(package.name)
                 if package_name not in exists:
                     deps.append(DepConfig(require, None))
diff --git a/tests/integration/test_provision_int.py b/tests/integration/test_provision_int.py
index 01f3cfec8..b002f0ee7 100644
--- a/tests/integration/test_provision_int.py
+++ b/tests/integration/test_provision_int.py
@@ -23,7 +23,8 @@ def test_provision_missing(initproj, cmd):
                 minversion = 3.7.0
                 requires =
                     setuptools == 40.6.3
-                    pyparsing!=2.4.1,!=2.4.1.1;python_version=="3.4"
+                    # remove when 2.4.2 is released or python3.4 is dropped
+                    pyparsing!=2.4.1,!=2.4.1.1
                 [testenv]
                 commands=python -c "import sys; print(sys.executable); raise SystemExit(1)"
             """
diff --git a/tests/unit/session/test_provision.py b/tests/unit/session/test_provision.py
index e8f7abc23..c2840197c 100644
--- a/tests/unit/session/test_provision.py
+++ b/tests/unit/session/test_provision.py
@@ -24,10 +24,10 @@ def test_provision_min_version_is_requires(newconfig, next_tox_major):
     with pytest.raises(MissingRequirement) as context:
         newconfig(
             [],
-            """
+            """\
             [tox]
             minversion = {}
-        """.format(
+            """.format(
                 next_tox_major
             ),
         )
@@ -45,10 +45,10 @@ def test_provision_min_version_is_requires(newconfig, next_tox_major):
 def test_provision_tox_change_name(newconfig):
     config = newconfig(
         [],
-        """
+        """\
         [tox]
         provision_tox_env = magic
-    """,
+        """,
     )
     assert config.provision_tox_env == "magic"
 
@@ -58,12 +58,12 @@ def test_provision_basepython_global_only(newconfig, next_tox_major):
     with pytest.raises(MissingRequirement) as context:
         newconfig(
             [],
-            """
+            """\
             [tox]
             minversion = {}
             [testenv]
             basepython = what
-        """.format(
+            """.format(
                 next_tox_major
             ),
         )
@@ -77,12 +77,12 @@ def test_provision_basepython_local(newconfig, next_tox_major):
     with pytest.raises(MissingRequirement) as context:
         newconfig(
             [],
-            """
+            """\
             [tox]
             minversion = {}
             [testenv:.tox]
             basepython = what
-        """.format(
+            """.format(
                 next_tox_major
             ),
         )
@@ -95,10 +95,10 @@ def test_provision_bad_requires(newconfig, capsys, monkeypatch):
     with pytest.raises(BadRequirement):
         newconfig(
             [],
-            """
+            """\
             [tox]
             requires = sad >sds d ok
-        """,
+            """,
         )
     out, err = capsys.readouterr()
     assert "ERROR: failed to parse InvalidRequirement" in out
@@ -208,7 +208,7 @@ def test_provision_non_canonical_dep(
     initproj(
         "w-0.1",
         {
-            "tox.ini": """
+            "tox.ini": """\
             [tox]
             envlist = py
             requires =
@@ -231,6 +231,21 @@ def test_provision_non_canonical_dep(
     result.assert_success(is_run_test_env=False)
 
 
+def test_provision_requirement_with_environment_marker(cmd, initproj):
+    initproj(
+        "proj",
+        {
+            "tox.ini": """\
+            [tox]
+            requires =
+                package-that-does-not-exist;python_version=="1.0"
+            """
+        },
+    )
+    result = cmd("-e", "py", "-vv")
+    result.assert_success(is_run_test_env=False)
+
+
 def space_path2url(path):
     at_path = str(path)
     if " " not in at_path: