Localized Intolerance Model using Bayesian Regression (LIMBR)

We fit a Bayesian hierarchical model explicitly characterizing depletion in functional variation at both the gene and sub-regional level. Our manuscript "Improved Pathogenic Variant Localization via a Hierarchical Model of Sub-regionnal Intolerance" contains more details along with our web resource can be found here,
Also, an overview can be found here