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With selsim, an evolving population of sequences is simulated according to a haploid Wright-Fisher model with discrete generations. This uses a Jukes-Cantor mutation model with a specified mutation rate. In each subsequent generation, the population is reconstituted by sampling sequences with replacement proportional to their frequency multiplied by their fitness. Mutations can be advantageous or deleterious and affect fitness in a multiplicative fashion (additive on a log-scale). Sequences are sampled at random time points after a period of burn-in.

Each time there is a mutation that affects fitness, I increment the "fitness class" of that sequence. This makes it possible, through BEAST's discrete trait models to analyze where and when on the phylogeny the advantageous or deleterious mutations fall. However, this only works for situations with only neutral and deleterious mutations or situations with only neutral and advantageous mutations. Using both deleterious and advantageous mutations, i.e. ADVPRO and DELPRO both > 0, will work, but output files will not be as interpretable.

Parameters are all in in.param, no re-compile is needed.

Compile with: make Run with: ./selsim

Please cite: Bedford T, Cobey S, Pascual M. 2011. Strength and tempo of selection revealed in viral gene genealogies. BMC Evol Biol 11: 220.

Output files:

out.beast: Formatted XML output of sequences and dates of all samples. Set up to run a simple BEAST analysis, with a skyline demographic model and mutational parameters set at their known values. Effective population sizes, sequence mutation rate are estimated.

With selection (positive or negative):

out.fitness: Tabbed-file of sample date, fitness and fitness class for each sample.

out.beast: Includes a discrete-trait analysis of fitness classes over the phylogeny. Gives a coloring to the tree. Set up to only allow transitions from fitness class i to i+1.
Fitness class mutation rate is estimated.

With PRINTPOPULATION:

out.pop: Every sequence in the population printed in increments of PRINTSTEP.

With PRINTDIVERSITY:

out.diversity: Print the mean pairwise diversity of population of sequences every PRINTSTEP.

Copyright 2011 Trevor Bedford

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