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Revise B cell slides

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sarahCobey committed Jul 17, 2019
1 parent 9a1f73a commit 288847b9767f355b0ba75f25d82eebc3483d3bef
Showing with 28 additions and 19 deletions.
  1. BIN bcells/images/cohort_ve.png
  2. +28 −19 bcells/slides.html
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@@ -77,7 +77,6 @@ <h3>Structure of a B cell receptor</h3>
<h3>Origins of B cell receptor diversity</h3>
<p>VDJ recombination
<p>Affinity maturation

</section>

<section>
@@ -134,6 +133,16 @@ <h3>Dynamics in one GC</h3>
</div>
</section>

<section>
<h3>Ab feedback may diversify the repertoire</h3>
<img class="stretch" src="images/em_div.png">
<div class="citation">
<a href="http://cobeylab.uchicago.edu/publications">
Childs et al. 2015
</a>
</div>
</section>

<section>
<h3>GC B cells evolve</h3>
<img class="stretch" src="images/gc_micro.png">
@@ -176,7 +185,7 @@ <h3>GCs produce plasma and memory cells</h3>
</section>

<section>
<h3>Memory cells can evolve further</h3>
<h3>(Can?) Memory cells evolve further (?)</h3>
<img src="images/andrews_memory.jpg" style="width: 70%; height: 70%;">
<div class="citation">
<a href="http://stm.sciencemag.org/content/7/316/316ra192">
@@ -185,17 +194,6 @@ <h3>Memory cells can evolve further</h3>
</div>
</section>


<section>
<h3>Ab feedback may diversify the repertoire</h3>
<img class="stretch" src="images/em_div.png">
<div class="citation">
<a href="http://cobeylab.uchicago.edu/publications">
Childs et al. 2015
</a>
</div>
</section>

<section>
<h3>Clones can be long-lived</h3>
<img class="stretch" src="images/ch103.png">
@@ -227,9 +225,9 @@ <h3>Broadly neutralizing antibodies to flu elusive</h3>
</section>

<section data-background="#99CCFF">
<p>Why do some people develop broadly neutralizing antibodies?</p>
<p>Can we induce them in everyone?
<p>Will they dominate?
<p>Why do some people develop more bnAbs?
<p>Can we induce high levels in everyone?
<p>How can we guarantee they will dominate?
</section>

<section>
@@ -371,6 +369,7 @@ <h3>Early infections affect vaccine response</h3>
</a>
</div>
</section>


<section>
<h3>Response to 2009 H1N1 vaccine</h3>
@@ -413,15 +412,15 @@ <h3>Stalk antibodies are more polyreactive</h3>
</section>

<section data-background="#99CCFF">
<h3>Potential factors influencing specific antibody responses</h3>
<h3>What determines Ab immunodominance?</h3>
<p>Host genotype
<p>Order (Age?) of infection
<p>Immunogenicity
<p>Autoreactivity
</section>

<section>
<h3>In U.S., flu vaccine coverage is high</h3>
<h3>In U.S., flu vaccine coverage is high(-ish)</h3>
<img src="images/vaccine_coverage.png" style="width: 60%; height: 60%;">
<div class="citation">
<a href="https://www.cdc.gov/flu/fluvaxview/coverage-1516estimates.htm">
@@ -431,7 +430,7 @@ <h3>In U.S., flu vaccine coverage is high</h3>
</section>

<section>
<h3>In RCT, vaccine provides high indirect protection</h3>
<h3>In RCT, vaccine provides indirect protection</h3>
<img src="images/hutterite.png" style="width: 90%; height: 90%;">
<div class="citation">
<a href="http://jamanetwork.com/journals/jama/fullarticle/185509">
@@ -471,6 +470,16 @@ <h3>Sin diminishes egg effects in 2012-2013?</h3>
</div>
</section>

<section>
<h3>Vaccine effectiveness tracks cohorts</h3>
<img src="images/cohort_ve.png" style="width: 60%; height: 60%;">
<div class="citation">
<a href="https://www.medrxiv.org/content/10.1101/19001875v1">
Arevalo et al. 2019
</a>
</div>
</section>

<section>
<h3>Another curiosity: low VE in repeat vaccinees</h3>
<img src="images/mclean.jpg" style="width: 90%; height: 90%;">

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