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ADR Mention Normalization

A supervised classification model for concept normalization of adversed drug reaction (ADR) mentions. Given a concept mention (without contextual information), this model predicts the corresponding MEDDRA Preferred Term (PT) code.

The deep architecture is hierarchical such that a forward character-level LSTM composes word representations. These word representations are then composed via a bi-directional LSTM to form the phrase (corresponding to the mention). The model is designed such that there are as many softmax output units as there are unique MEDDRA codes appearing in the training set.

Packages required:

numpy
sklearn
pandas
tensorflow 1.0.0 with tensorflow-fold

Data Format

Format of the training data:

ID <-tab-> Text <-tab-> MEDDRA PT

Format of the unlabeled testing data:

ID <-tab-> Text

Training and Testing

The model is trained using annotated data located the data_train directory. The program will train 10 such models as part of an ensemble and store them in a local tmp directory. The program will then annotate unlabeled instances from data_test and print corresponding results to a new file named test_hiercharlstm.txt.

To execute the file, simply run:

python main.py

See the sample_output.txt file for the output of this model on this particular dataset.

The output format is:

ID <-tab-> MEDDRA PT

For example:

44675	10041349
40103	10000125
41585	10016322
41834	10019211
46301	10061920
41783	10019133
41184	10016322
45250	10047700
45856	10048010
45048	10044565
40652	10011469
...

To evaluate the test predictions, you must have the official test labels which are not provided in this repository.

For info on the related shared task, please refer to: https://healthlanguageprocessing.org/sharedtask2/

Acknowledgements

Please consider citing the following paper(s) if you use this software in your work:

Sifei Han, Tung Tran, Anthony Rios, and Ramakanth Kavuluru. "Team UKNLP: Detecting ADRs, Classifying Medication Intake Messages, and Normalizing ADR Mentions on Twitter" In Proceedings of the 2nd Social Media Mining for Health Research and Applications Workshop co-located with the American Medical Informatics Association Annual Symposium (AMIA 2017), vol-1996, pp. 49-53. 2017.

@inproceedings{han2017team,
  title={Team UKNLP: Detecting ADRs, Classifying Medication Intake Messages, and Normalizing ADR Mentions on Twitter},
  author={Han, Sifei and Tran, Tung and Rios, Anthony and Kavuluru, Ramakanth},
  booktitle={Social Media Mining for Health Research and Applications},
  pages={49--53},
  year={2017},
  organization={AMIA}
}

Author

Tung Tran
tung.tran [at] uky.edu
http://tttran.net/

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A deep neural model for concept normalization of adverse drug reaction (ADR) mentions.

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