diff --git a/tests/unit/rest/test_client.py b/tests/unit/rest/test_client.py
index 9623dc52ad..1043d6dcf8 100644
--- a/tests/unit/rest/test_client.py
+++ b/tests/unit/rest/test_client.py
@@ -1,7 +1,10 @@
 import unittest
+import warnings
+
 import aiounittest
 
 from mock import AsyncMock, Mock
+
 from twilio.http.response import Response
 from twilio.rest import Client
 
@@ -18,16 +21,16 @@ def test_set_client_edge_default_region(self):
         )
 
     def test_set_client_region(self):
-        self.client.region = "region"
+        self.client.region = "us1"
         self.assertEqual(
             self.client.get_hostname("https://api.twilio.com"),
-            "https://api.region.twilio.com",
+            "https://api.us1.twilio.com",
         )
 
     def test_set_uri_region(self):
         self.assertEqual(
-            self.client.get_hostname("https://api.region.twilio.com"),
-            "https://api.region.twilio.com",
+            self.client.get_hostname("https://api.us1.twilio.com"),
+            "https://api.us1.twilio.com",
         )
 
     def test_set_client_edge_region(self):
@@ -75,6 +78,27 @@ def test_periods_in_query(self):
             "https://api.edge.region.twilio.com/path/to/something.json?foo=12.34",
         )
 
+    def test_edge_deprecation_warning_when_only_edge_is_set(self):
+        with warnings.catch_warnings(record=True) as w:
+            warnings.simplefilter("always")  # Ensure all warnings are caught
+            Client(username="username", password="password", edge="edge")  # Trigger the warning
+
+            # Check if a warning was raised
+            self.assertGreater(len(w), 0)
+            self.assertTrue(issubclass(w[-1].category, DeprecationWarning))
+            self.assertIn("For regional processing, DNS is of format product.<edge>.<region>.twilio.com; otherwise use product.twilio.com.", str(w[-1].message))
+
+    def test_edge_deprecation_warning_when_only_region_is_set(self):
+        with warnings.catch_warnings(record=True) as w:
+            warnings.simplefilter("always")  # Ensure all warnings are caught
+            Client(username="username", password="password", region="us1")  # Trigger the warning
+
+            # Check if a warning was raised
+            self.assertGreater(len(w), 0)
+            self.assertTrue(issubclass(w[-1].category, DeprecationWarning))
+            self.assertIn("For regional processing, DNS is of format product.<edge>.<region>.twilio.com; otherwise use product.twilio.com.", str(w[-1].message))
+
+
 
 class TestUserAgentClients(unittest.TestCase):
     def setUp(self):
diff --git a/twilio/base/client_base.py b/twilio/base/client_base.py
index b16f85bf5b..2fac31b80a 100644
--- a/twilio/base/client_base.py
+++ b/twilio/base/client_base.py
@@ -1,5 +1,6 @@
 import os
 import platform
+import warnings
 from typing import Dict, List, MutableMapping, Optional, Tuple
 from urllib.parse import urlparse, urlunparse
 
@@ -12,7 +13,17 @@
 
 class ClientBase(object):
     """A client for accessing the Twilio API."""
-
+    region_mappings = {
+        "au1": "sydney",
+        "br1": "sao-paulo",
+        "de1": "frankfurt",
+        "ie1": "dublin",
+        "jp1": "tokyo",
+        "jp2": "osaka",
+        "sg1": "singapore",
+        "us1": "ashburn",
+        "us2": "umatilla"
+    }
     def __init__(
         self,
         username: Optional[str] = None,
@@ -34,7 +45,7 @@ def __init__(
         :param region: Twilio Region to make requests to, defaults to 'us1' if an edge is provided
         :param http_client: HttpClient, defaults to TwilioHttpClient
         :param environment: Environment to look for auth details, defaults to os.environ
-        :param edge: Twilio Edge to make requests to, defaults to None
+        :param edge: Twilio Edge to make requests to, defaults to None.
         :param user_agent_extensions: Additions to the user agent string
         :param credential_provider: credential provider for authentication method that needs to be used
         """
@@ -45,7 +56,13 @@ def __init__(
         """ :type : str """
         self.password = password or environment.get("TWILIO_AUTH_TOKEN")
         """ :type : str """
-        self.edge = edge or environment.get("TWILIO_EDGE")
+        if (edge is not None and region is None) or (region is not None and edge is None):
+            warnings.warn(
+                "For regional processing, DNS is of format product.<edge>.<region>.twilio.com; otherwise use product.twilio.com.",
+                DeprecationWarning,
+                stacklevel=2
+            )
+        self.edge = edge or environment.get("TWILIO_EDGE") or (self.region_mappings[region] if region is not None else "")
         """ :type : str """
         self.region = region or environment.get("TWILIO_REGION")
         """ :type : str """