diff --git a/.github/workflows/nightly_wheels.yaml b/.github/workflows/nightly_wheels.yaml
new file mode 100644
index 000000000..f5feb3dbc
--- /dev/null
+++ b/.github/workflows/nightly_wheels.yaml
@@ -0,0 +1,200 @@
+#A* -------------------------------------------------------------------
+#B* This file contains source code for running a GitHub automation
+#-* related to the build process of the PyMOL computer program
+#C* Copyright 2025 by Martin Urban.
+#D* -------------------------------------------------------------------
+#E* It is unlawful to modify or remove this copyright notice.
+#F* -------------------------------------------------------------------
+#G* Please see the accompanying LICENSE file for further information.
+#H* -------------------------------------------------------------------
+#I* Additional authors of this source file include:
+#-*
+#-*
+#-*
+#Z* -------------------------------------------------------------------
+name: Build Nightly Wheels
+
+on:
+  push:
+    branches:
+      - unstable
+
+env:
+  VCPKG_ROOT: ${{ github.workspace }}/vendor/vcpkg
+
+jobs:
+  # ----- Windows build section
+  build-windows:
+    strategy:
+      fail-fast: false
+      matrix:
+        win_arch: ['x86', 'x64']
+    runs-on: windows-latest
+    steps:
+      - name: Checkout repository
+        uses: actions/checkout@v4
+        with:
+          submodules: recursive
+
+      - name: Initialize vcpkg
+        run: |
+          git clone https://github.com/Microsoft/vcpkg.git vendor/vcpkg
+
+      - name: Setup Python 3.11
+        uses: actions/setup-python@v5
+        with:
+          python-version: "3.11"
+
+      - name: Create virtual environment
+        run: |
+          python -m venv .venv
+          call .venv\Scripts\activate.bat
+          python -m pip install --upgrade setuptools pip wheel build cibuildwheel 
+          python -m pip install delvewheel
+          python -m pip install -r requirements.txt
+        shell: cmd
+
+      - name: Bootstrap vcpkg
+        run: ${{ env.VCPKG_ROOT }}/bootstrap-vcpkg.bat -disableMetrics
+
+      - name: Last build environment setup steps
+        run: |
+          call .venv\Scripts\activate.bat
+          python automations\my_automator.py setup dev-env
+        shell: cmd
+
+      - name: Build x86 C extension
+        if: ${{ matrix.win_arch == 'x86' }}
+        run: |
+          ${{ env.VCPKG_ROOT }}/vcpkg install --triplet=x86-windows-static
+          call .venv\Scripts\activate.bat
+          set WIN_ARCH=x86
+          cibuildwheel . --platform windows --archs x86
+        shell: cmd
+
+      - name: Build x64 C extension
+        if: ${{ matrix.win_arch == 'x64' }}
+        run: |
+          ${{ env.VCPKG_ROOT }}/vcpkg install --triplet=x64-windows-static
+          call .venv\Scripts\activate.bat
+          set WIN_ARCH=x64
+          cibuildwheel . --platform windows --archs AMD64
+        shell: cmd
+
+      - name: Upload artifact
+        uses: actions/upload-artifact@v4
+        with:
+          name: PyMOL-wheel-Windows-${{ matrix.win_arch }}-nightly
+          path: ./wheelhouse/*.whl
+  # --- end
+
+  # ----- macOS build section
+  build-macos:
+    strategy:
+      fail-fast: false
+      matrix:
+        os: [ macos-13, macos-14 ]
+    runs-on: ${{ matrix.os }}
+    steps:
+      - name: Checkout repository
+        uses: actions/checkout@v4
+        with:
+          submodules: recursive
+
+      - name: Initialize vcpkg
+        run: |
+          git clone https://github.com/Microsoft/vcpkg.git vendor/vcpkg
+
+      - name: Setup Python 3.11
+        uses: actions/setup-python@v5
+        with:
+          python-version: "3.11"
+
+      - name: Create virtual environment
+        run: |
+          python -m venv .venv
+          source .venv/bin/activate
+          python -m pip install wheel setuptools cibuildwheel 
+          python -m pip install -r requirements.txt
+
+      - name: Bootstrap vcpkg
+        run: ${{ env.VCPKG_ROOT }}/bootstrap-vcpkg.sh -disableMetrics
+
+      - name: Install vcpkg dependencies
+        run: |
+          ${{ env.VCPKG_ROOT }}/vcpkg install
+
+      - name: Last build environment setup steps
+        run: |
+          source .venv/bin/activate
+          python automations/my_automator.py setup dev-env
+
+      - name: Build C extension
+        run: |
+          source .venv/bin/activate
+          python automations/my_automator.py setup dev-env
+          export ARCH=$(uname -m)
+          export MACOSX_DEPLOYMENT_TARGET=12.0
+          cibuildwheel .
+
+      - name: Upload artifact
+        uses: actions/upload-artifact@v4
+        with:
+          name: PyMOL-wheel-${{ matrix.os }}-nightly
+          path: ./wheelhouse/*.whl
+  # --- end
+
+  # ----- GNU Linux build section
+  build-gnu-linux:
+    runs-on: ubuntu-22.04
+    steps:
+      - name: Checkout repository
+        uses: actions/checkout@v4
+        with:
+          submodules: recursive
+
+      - name: Install system dependencies
+        run: |
+          sudo apt-get update
+          sudo apt-get install git build-essential libxmu-dev libxi-dev libgl-dev libglew-dev libpng-dev libfreetype6-dev libxml2-dev libmsgpack-dev libglm-dev libnetcdf-dev linux-libc-dev autoconf perl
+
+      - name: Initialize vcpkg
+        run: |
+          git clone https://github.com/Microsoft/vcpkg.git vendor/vcpkg
+
+      - name: Setup Python 3.11
+        uses: actions/setup-python@v5
+        with:
+          python-version: "3.11"
+
+      - name: Create virtual environment
+        run: |
+          python -m venv .venv
+          source .venv/bin/activate
+          python -m pip install wheel setuptools cibuildwheel 
+          python -m pip install -r requirements.txt
+
+      - name: Bootstrap vcpkg
+        run: ${{ env.VCPKG_ROOT }}/bootstrap-vcpkg.sh -disableMetrics
+
+      - name: Install vcpkg dependencies
+        run: |
+          ${{ env.VCPKG_ROOT }}/vcpkg install
+
+      - name: Last build environment setup steps
+        run: |
+          source .venv/bin/activate
+          python automations/my_automator.py setup dev-env
+
+      - name: Build C extension
+        run: |
+          source .venv/bin/activate
+          python automations/my_automator.py setup dev-env
+          cibuildwheel .
+
+      - name: Upload artifact
+        uses: actions/upload-artifact@v4
+        with:
+          name: PyMOL-wheel-GNU-Linux-nightly
+          path: ./wheelhouse/*.whl
+  # --- end
diff --git a/modules/pmg_qt/pymol_gl_widget.py b/modules/pmg_qt/pymol_gl_widget.py
index 44b95822a..ac796956d 100644
--- a/modules/pmg_qt/pymol_gl_widget.py
+++ b/modules/pmg_qt/pymol_gl_widget.py
@@ -63,7 +63,14 @@ def __exit__(self, exc_type, exc_value, traceback):
 
     def __init__(self, parent):
         self.gui = parent
-        self.fb_scale = 1.0
+        app = QtWidgets.QApplication.instance()
+        if app:
+            screen = app.primaryScreen()
+            # use the screen's devicePixelRatio as framebuffer scale factor necessary for PyQt6 high DPI support
+            self.fb_scale = screen.devicePixelRatio()
+        else:
+            # fallback if no QApplication instance is available
+            self.fb_scale = 1.0
 
         # OpenGL context setup
         if USE_QOPENGLWIDGET:
diff --git a/pyproject.toml b/pyproject.toml
index e57e73057..f3bb8ccd8 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -9,7 +9,7 @@ build-backend = "scikit_build_core.build"
 [project]
 name = "pymol-open-source-whl"
 readme = "README.md"
-version = "3.1.0.4"
+version = "3.1.0.4a1+1"
 requires-python = ">=3.10"
 license = {file = "LICENSE"}
 #description = """