diff --git a/@xen-orchestra/fs/package.json b/@xen-orchestra/fs/package.json
index 89a02ebed99..64ca7f2c2a8 100644
--- a/@xen-orchestra/fs/package.json
+++ b/@xen-orchestra/fs/package.json
@@ -22,6 +22,7 @@
   "dependencies": {
     "@aws-sdk/client-s3": "^3.54.0",
     "@aws-sdk/lib-storage": "^3.54.0",
+    "@aws-sdk/middleware-apply-body-checksum": "^3.58.0",
     "@aws-sdk/node-http-handler": "^3.54.0",
     "@marsaud/smb2": "^0.18.0",
     "@sindresorhus/df": "^3.1.1",
diff --git a/@xen-orchestra/fs/src/s3.js b/@xen-orchestra/fs/src/s3.js
index 528064360c3..8595c224303 100644
--- a/@xen-orchestra/fs/src/s3.js
+++ b/@xen-orchestra/fs/src/s3.js
@@ -14,6 +14,7 @@ import {
 } from '@aws-sdk/client-s3'
 import { Upload } from '@aws-sdk/lib-storage'
 import { NodeHttpHandler } from '@aws-sdk/node-http-handler'
+import { getApplyMd5BodyChecksumPlugin } from '@aws-sdk/middleware-apply-body-checksum'
 import assert from 'assert'
 import { Agent as HttpAgent } from 'http'
 import { Agent as HttpsAgent } from 'https'
@@ -75,6 +76,11 @@ export default class S3Handler extends RemoteHandlerAbstract {
       }),
     })
 
+    // Workaround for https://github.com/aws/aws-sdk-js-v3/issues/2673
+    this._s3.middlewareStack.use(
+      getApplyMd5BodyChecksumPlugin(this._s3.config)
+    )
+
     const parts = split(path)
     this._bucket = parts.shift()
     this._dir = join(...parts)
diff --git a/CHANGELOG.unreleased.md b/CHANGELOG.unreleased.md
index c14fc4a68ba..2f42ec4aecf 100644
--- a/CHANGELOG.unreleased.md
+++ b/CHANGELOG.unreleased.md
@@ -16,6 +16,7 @@
 
 - [VM/Host Console] Fix support of older versions of XCP-ng/XS, please not that HTTP proxies are note supported in that case [#6191](https://github.com/vatesfr/xen-orchestra/pull/6191)
 - Fix HTTP proxy support to connect to pools (introduced in XO 5.69.0) [#6204](https://github.com/vatesfr/xen-orchestra/pull/6204)
+- [Backup] Fix failure when sending a backup (Full/Delta/Metadata) to S3 with Object Lock enabled (PR [#6190](https://github.com/vatesfr/xen-orchestra/pull/6190))
 
 ### Packages to release
 
@@ -38,6 +39,10 @@
 - @vates/event-listeners-manager major
 - xen-api minor
 - xo-vmdk-to-vhd minor
+- @xen-orchestra/fs patch
 - @xen-orchestra/proxy patch
+- @xen-orchestra/backups patch
 - xo-server minor
 - xo-web minor
+- vhd-cli patch
+- @xen-orchestra/backups-cli patch
diff --git a/yarn.lock b/yarn.lock
index 9c5aac54349..08d7f074a02 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -464,6 +464,16 @@
     "@aws-sdk/util-utf8-node" "3.55.0"
     tslib "^2.3.1"
 
+"@aws-sdk/middleware-apply-body-checksum@^3.58.0":
+  version "3.58.0"
+  resolved "https://registry.yarnpkg.com/@aws-sdk/middleware-apply-body-checksum/-/middleware-apply-body-checksum-3.58.0.tgz#f14b9c96f3cc9e567b49184ebda96db84317811f"
+  integrity sha512-sAdY2IbFFgCdhBdiY7CamlShgZrFuli1eVJF60yndqSyVM5hUvOg4fNsMqXWCSqJ83151T3yf/j7G78yfoSt9g==
+  dependencies:
+    "@aws-sdk/is-array-buffer" "3.55.0"
+    "@aws-sdk/protocol-http" "3.58.0"
+    "@aws-sdk/types" "3.55.0"
+    tslib "^2.3.1"
+
 "@aws-sdk/middleware-bucket-endpoint@3.58.0":
   version "3.58.0"
   resolved "https://registry.yarnpkg.com/@aws-sdk/middleware-bucket-endpoint/-/middleware-bucket-endpoint-3.58.0.tgz#cec84100ff776862e3bbd4bd596a1e869ad81e5e"