diff --git a/packages/next/src/server/app-render/create-component-styles-and-scripts.tsx b/packages/next/src/server/app-render/create-component-styles-and-scripts.tsx
index 5563c734f10894..5c29ad5a3b9efc 100644
--- a/packages/next/src/server/app-render/create-component-styles-and-scripts.tsx
+++ b/packages/next/src/server/app-render/create-component-styles-and-scripts.tsx
@@ -26,12 +26,6 @@ export async function createComponentStylesAndScripts({
 
   const styles = cssHrefs
     ? cssHrefs.map((href, index) => {
-        // In dev, Safari and Firefox will cache the resource during HMR:
-        // - https://github.com/vercel/next.js/issues/5860
-        // - https://bugs.webkit.org/show_bug.cgi?id=187726
-        // Because of this, we add a `?v=` query to bypass the cache during
-        // development. We need to also make sure that the number is always
-        // increasing.
         const fullHref = `${ctx.assetPrefix}/_next/${href}${getAssetQueryString(
           ctx,
           true
diff --git a/packages/next/src/server/app-render/get-asset-query-string.ts b/packages/next/src/server/app-render/get-asset-query-string.ts
index 145f01f4004252..fd6f49e4805d09 100644
--- a/packages/next/src/server/app-render/get-asset-query-string.ts
+++ b/packages/next/src/server/app-render/get-asset-query-string.ts
@@ -1,13 +1,18 @@
 import type { AppRenderContext } from './app-render'
 
+const isDev = process.env.NODE_ENV === 'development'
+const isTurbopack = !!process.env.TURBOPACK
 export function getAssetQueryString(
   ctx: AppRenderContext,
   addTimestamp: boolean
 ) {
-  const isDev = process.env.NODE_ENV === 'development'
   let qs = ''
 
-  if (isDev && addTimestamp) {
+  // In development we add the request timestamp to allow react to
+  // reload assets when a new RSC response is received.
+  // Turbopack handles HMR of assets itself and react doesn't need to reload them
+  // so this approach is not needed for Turbopack.
+  if (isDev && !isTurbopack && addTimestamp) {
     qs += `?v=${ctx.requestTimestamp}`
   }
 
diff --git a/packages/next/src/server/app-render/get-layer-assets.tsx b/packages/next/src/server/app-render/get-layer-assets.tsx
index 1f56bcb66f0ca9..553b9407ddf73b 100644
--- a/packages/next/src/server/app-render/get-layer-assets.tsx
+++ b/packages/next/src/server/app-render/get-layer-assets.tsx
@@ -95,7 +95,10 @@ export function getLayerAssets({
 
   const scripts = scriptTags
     ? scriptTags.map((href, index) => {
-        const fullSrc = `${ctx.assetPrefix}/_next/${href}`
+        const fullSrc = `${ctx.assetPrefix}/_next/${href}${getAssetQueryString(
+          ctx,
+          true
+        )}`
 
         return <script src={fullSrc} async={true} key={`script-${index}`} />
       })
diff --git a/packages/next/src/server/render.tsx b/packages/next/src/server/render.tsx
index 7b079fbd7162ee..8a09f5df896dd1 100644
--- a/packages/next/src/server/render.tsx
+++ b/packages/next/src/server/render.tsx
@@ -416,12 +416,20 @@ export async function renderToHTMLImpl(
 
   const metadata: PagesRenderResultMetadata = {}
 
-  // In dev we invalidate the cache by appending a timestamp to the resource URL.
-  // This is a workaround to fix https://github.com/vercel/next.js/issues/5860
-  // TODO: remove this workaround when https://bugs.webkit.org/show_bug.cgi?id=187726 is fixed.
-  metadata.assetQueryString = renderOpts.dev
-    ? renderOpts.assetQueryString || `?ts=${Date.now()}`
-    : ''
+  metadata.assetQueryString =
+    (renderOpts.dev && renderOpts.assetQueryString) || ''
+
+  if (renderOpts.dev && !metadata.assetQueryString) {
+    const userAgent = (req.headers['user-agent'] || '').toLowerCase()
+    if (userAgent.includes('safari') && !userAgent.includes('chrome')) {
+      // In dev we invalidate the cache by appending a timestamp to the resource URL.
+      // This is a workaround to fix https://github.com/vercel/next.js/issues/5860
+      // TODO: remove this workaround when https://bugs.webkit.org/show_bug.cgi?id=187726 is fixed.
+      // Note: The workaround breaks breakpoints on reload since the script url always changes,
+      // so we only apply it to Safari.
+      metadata.assetQueryString = `?ts=${Date.now()}`
+    }
+  }
 
   // if deploymentId is provided we append it to all asset requests
   if (renderOpts.deploymentId) {
diff --git a/test/integration/app-document/test/index.test.js b/test/integration/app-document/test/index.test.js
index cb606f37c4643e..9fc0639cd5e72b 100644
--- a/test/integration/app-document/test/index.test.js
+++ b/test/integration/app-document/test/index.test.js
@@ -45,8 +45,14 @@ describe('Document and App', () => {
   rendering(
     context,
     'Rendering via HTTP',
-    (p, q) => renderViaHTTP(context.appPort, p, q),
-    (p, q) => fetchViaHTTP(context.appPort, p, q)
+    (p, q) =>
+      renderViaHTTP(context.appPort, p, q, {
+        headers: { 'user-agent': 'Safari' },
+      }),
+    (p, q) =>
+      fetchViaHTTP(context.appPort, p, q, {
+        headers: { 'user-agent': 'Safari' },
+      })
   )
   client(context, (p, q) => renderViaHTTP(context.appPort, p, q))
   csp(context, (p, q) => renderViaHTTP(context.appPort, p, q))