diff --git a/packages/vite/src/node/optimizer/esbuildDepPlugin.ts b/packages/vite/src/node/optimizer/esbuildDepPlugin.ts
index b794ccd687ccb7..735db79222166c 100644
--- a/packages/vite/src/node/optimizer/esbuildDepPlugin.ts
+++ b/packages/vite/src/node/optimizer/esbuildDepPlugin.ts
@@ -18,6 +18,10 @@ const externalTypes = [
   // known SFC types
   'vue',
   'svelte',
+  // JSX/TSX may be configured to be compiled differently from how esbuild
+  // handles it by default, so exclude them as well
+  'jsx',
+  'tsx',
   ...KNOWN_ASSET_TYPES
 ]