diff --git a/packages/vite/src/node/optimizer/index.ts b/packages/vite/src/node/optimizer/index.ts
index 7d8bf259c8fe02..1b1fd521d34a7a 100644
--- a/packages/vite/src/node/optimizer/index.ts
+++ b/packages/vite/src/node/optimizer/index.ts
@@ -234,6 +234,7 @@ export async function optimizeDeps(
     splitting: true,
     sourcemap: true,
     outdir: cacheDir,
+    treeShaking: 'ignore-annotations',
     metafile: esbuildMetaPath,
     define: {
       'process.env.NODE_ENV': '"development"'