diff --git a/packages/vite/src/node/server/middlewares/indexHtml.ts b/packages/vite/src/node/server/middlewares/indexHtml.ts
index 9d870fe8df8f19..45d0e8f3749eae 100644
--- a/packages/vite/src/node/server/middlewares/indexHtml.ts
+++ b/packages/vite/src/node/server/middlewares/indexHtml.ts
@@ -151,6 +151,10 @@ export function indexHtmlMiddleware(
 ): Connect.NextHandleFunction {
   // Keep the named function. The name is visible in debug logs via `DEBUG=connect:dispatcher ...`
   return async function viteIndexHtmlMiddleware(req, res, next) {
+    if (res.writableEnded) {
+      return next()
+    }
+
     const url = req.url && cleanUrl(req.url)
     // spa-fallback always redirects to /index.html
     if (url?.endsWith('.html') && req.headers['sec-fetch-dest'] !== 'script') {
diff --git a/packages/vite/src/node/server/send.ts b/packages/vite/src/node/server/send.ts
index 1c54ec46f88af8..777e91abf9438c 100644
--- a/packages/vite/src/node/server/send.ts
+++ b/packages/vite/src/node/server/send.ts
@@ -20,6 +20,10 @@ export function send(
   cacheControl = 'no-cache',
   map?: SourceMap | null
 ): void {
+  if (res.writableEnded) {
+    return
+  }
+
   if (req.headers['if-none-match'] === etag) {
     res.statusCode = 304
     return res.end()