diff --git a/packages/runtime-core/__tests__/components/Suspense.spec.ts b/packages/runtime-core/__tests__/components/Suspense.spec.ts
index a448972e139..8de5b3182d0 100644
--- a/packages/runtime-core/__tests__/components/Suspense.spec.ts
+++ b/packages/runtime-core/__tests__/components/Suspense.spec.ts
@@ -2021,7 +2021,7 @@ describe('Suspense', () => {
     viewRef.value = 0
     await nextTick()
 
-    expect(serializeInner(root)).toBe('<!---->')
+    expect(serializeInner(root)).toBe('<div>sync</div>')
 
     await Promise.all(deps)
     await nextTick()
@@ -2035,6 +2035,56 @@ describe('Suspense', () => {
     expect(serializeInner(root)).toBe(`<div>sync</div>`)
   })
 
+  // #10899
+  test('KeepAlive + Suspense switch before branch resolves', async () => {
+    const Async1 = defineAsyncComponent({
+      render() {
+        return h('div', 'async1')
+      },
+    })
+    const Async2 = defineAsyncComponent({
+      render() {
+        return h('div', 'async2')
+      },
+    })
+    const components = [Async1, Async2]
+    const viewRef = ref(0)
+    const root = nodeOps.createElement('div')
+    const App = {
+      render() {
+        return h(KeepAlive, null, {
+          default: () => {
+            return h(Suspense, null, {
+              default: h(components[viewRef.value]),
+              fallback: h('div', 'loading'),
+            })
+          },
+        })
+      },
+    }
+    render(h(App), root)
+    expect(serializeInner(root)).toBe(`<div>loading</div>`)
+
+    // switch to Async2 before Async1 resolves
+    viewRef.value = 1
+    await nextTick()
+    expect(serializeInner(root)).toBe(`<div>loading</div>`)
+
+    await Promise.all(deps)
+    await nextTick()
+    expect(serializeInner(root)).toBe('<div>async2</div>')
+
+    viewRef.value = 0
+    await nextTick()
+    await Promise.all(deps)
+    expect(serializeInner(root)).toBe(`<div>async1</div>`)
+
+    viewRef.value = 1
+    await nextTick()
+    await Promise.all(deps)
+    expect(serializeInner(root)).toBe(`<div>async2</div>`)
+  })
+
   // #6416 follow up / #10017
   test('Suspense patched during HOC async component re-mount', async () => {
     const key = ref('k')
diff --git a/packages/runtime-core/src/components/KeepAlive.ts b/packages/runtime-core/src/components/KeepAlive.ts
index db6088cf5c6..37084d5f37a 100644
--- a/packages/runtime-core/src/components/KeepAlive.ts
+++ b/packages/runtime-core/src/components/KeepAlive.ts
@@ -228,7 +228,15 @@ const KeepAliveImpl: ComponentOptions = {
     const cacheSubtree = () => {
       // fix #1621, the pendingCacheKey could be 0
       if (pendingCacheKey != null) {
-        cache.set(pendingCacheKey, getInnerChild(instance.subTree))
+        // if KeepAlive child is a Suspense, it needs to be cached after Suspense resolves
+        // avoid caching vnode that not been mounted
+        if (isSuspense(instance.subTree.type)) {
+          queuePostRenderEffect(() => {
+            cache.set(pendingCacheKey!, getInnerChild(instance.subTree))
+          }, instance.subTree.suspense)
+        } else {
+          cache.set(pendingCacheKey, getInnerChild(instance.subTree))
+        }
       }
     }
     onMounted(cacheSubtree)