The ATLAS (Altered TCR Ligand Affinities and Structures) database is a manually curated repository containing the binding affinities for wild-type and mutant T cell receptors (TCRs) and their antigens, peptides presented by the major histocompatibility complex (MHC). The database links experimentally measured binding affinities with the corresponding three dimensional structures for TCR-pMHC complexes.
The ATLAS git repository houses all the code for the ATLAS site along with a collection of scripts used for prediction of TCR-pMHC binding affinity from ATLAS data.
Contributing to ATLAS
All contributions, bug reports, bug fixes, documentation improvements, enhancements, and ideas are welcome!
Tyler Borrman, Jennifer Cimons, Michael Cosiano, Michael Purcaro, Brian G. Pierce, Brian M. Baker, and Zhiping Weng. (2017). ATLAS: A database linking binding affinities with structures for wild-type and mutant TCR-pMHC complexes. Proteins: Structure, Function, and Bioinformatics