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Humanization of yeast genes
2015-05-21 10:00:00 -0700

In the May 22 issue of Science Magazine, we are publishing an article on systematic replacement of essential genes in baker's yeast with corresponding human orthologs. This work, spearheaded by the Marcotte lab at UT Austin, demonstrates that almost 50% of these yeast genes can be replaced by their human counterparts, despite over a billion years of evolutionary divergence between humans and yeast. Wilke-lab postdoc Austin Meyer contributed computational modeling to this study, and showed that continued selection for specific function can maintain replaceability despite substantial sequence divergence.

The UT Austin press release on this study is available here, and Science Magazine published a news feature on this study here.

Other news features on this paper: phys.orgDiscovery NewsThe ScientistScience dailyMeteoWeb (in Italian)NBC NewsWashington PostReddit #1Science NewsEmpire State TribuneSoftpediaReddit #2Daily MailredOrbitMedical DailyNYC TodayGenetic Literacy ProjectTechie NewsTech TimesAmerican Live WirePioneer NewsYahoo NewsIFLScienceyeastgenome.orgOttawa CitizenPRI

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(News features and podcasts updated as they appear.)