diff --git a/MANIFEST.in b/MANIFEST.in
index 7e1cc57cc..74a09ff5c 100644
--- a/MANIFEST.in
+++ b/MANIFEST.in
@@ -11,6 +11,7 @@ recursive-include   wx/locale **
 recursive-include   wx/include **
 recursive-include   license  *.txt
 include             LICENSE.txt
+include             pyproject.toml
 graft               docs
 prune               docs/sphinx/build
 
diff --git a/build.py b/build.py
index a48b86db9..6e6c36954 100755
--- a/build.py
+++ b/build.py
@@ -43,7 +43,8 @@
                                phoenixDir, wxDir, copyIfNewer, copyFile, \
                                macSetLoaderNames, \
                                getVcsRev, runcmd, textfile_open, getSipFiles, \
-                               getVisCVersion, getToolsPlatformName, updateLicenseFiles
+                               getVisCVersion, getToolsPlatformName, updateLicenseFiles, \
+                               updatePyprojectFile
 
 import buildtools.version as version
 
@@ -180,6 +181,7 @@ def main(args):
         usage()
         sys.exit(1)
 
+    updatePyprojectFile()
     options, commands = parseArgs(args)
 
     cfg = Config(noWxConfig=True)
diff --git a/buildtools/config.py b/buildtools/config.py
index 0d99f1e7a..848dbfcc9 100644
--- a/buildtools/config.py
+++ b/buildtools/config.py
@@ -19,6 +19,7 @@
 import shutil
 import subprocess
 import platform
+import textwrap
 
 from distutils.file_util import copy_file
 from distutils.dir_util  import mkpath
@@ -969,3 +970,29 @@ def updateLicenseFiles(cfg):
     with open('LICENSE.txt', 'w') as f:
         f.write(text)
 
+
+def updatePyprojectFile():
+    """
+    Create or update  a pyproject.toml file based on the contents of
+    requirements/*.txt files.
+    """
+    assert os.getcwd() == phoenixDir()
+    target = 'pyproject.toml'
+    txt_files = glob.glob('requirements/*.txt')
+    if not os.path.exists(target) or any([newer(src, target) for src in txt_files]):
+        with open(target, "w") as output:
+            output.write(textwrap.dedent("""\
+                # Generated from {}
+
+                [build-system]
+                # Requirements for building and/or testing wxPython Phoenix
+                requires = [
+                """.format(txt_files)))
+            for tf in txt_files:
+                for line in open(tf).readlines():
+                    line = line.strip()
+                    if line[0] not in ['-', '#']:
+                        output.write("    '{}',\n".format(line))
+            output.write('    ]\n')
+        msg("Updated {}".format(target))
+
diff --git a/pyproject.toml b/pyproject.toml
new file mode 100644
index 000000000..91585e760
--- /dev/null
+++ b/pyproject.toml
@@ -0,0 +1,21 @@
+# Generated from ['requirements/devel.txt', 'requirements/install.txt']
+
+[build-system]
+# Requirements for building and/or testing wxPython Phoenix
+requires = [
+    'appdirs',
+    'setuptools',
+    'wheel',
+    'twine',
+    'sphinx==1.4.5',
+    'requests',
+    'pytest',
+    'pytest-xdist',
+    'pytest-timeout',
+    'pathlib2 ; python_version < "3"',
+    'backports.shutil_which ; python_version < "3"',
+    'textwrap3 ; python_version < "3"',
+    'numpy',
+    'pillow',
+    'six',
+    ]