diff --git a/bindings/python/.gitignore b/bindings/python/.gitignore
index f7e4859c728..22eb52622ed 100755
--- a/bindings/python/.gitignore
+++ b/bindings/python/.gitignore
@@ -2,4 +2,6 @@ build
 .project
 .pydevproject
 .cproject
-*.py[co]
\ No newline at end of file
+*.py[co]
+MANIFEST
+VERSION_INFO
diff --git a/bindings/python/MANIFEST.in b/bindings/python/MANIFEST.in
new file mode 100644
index 00000000000..2110b2157d3
--- /dev/null
+++ b/bindings/python/MANIFEST.in
@@ -0,0 +1,6 @@
+include README.rst
+include VERSION_INFO
+recursive-include tests *
+recursive-include examples *.py
+recursive-include docs *
+recursive-include src *
diff --git a/bindings/python/README.rst b/bindings/python/README.rst
index e69de29bb2d..cf5c2bd0129 100644
--- a/bindings/python/README.rst
+++ b/bindings/python/README.rst
@@ -0,0 +1,16 @@
+Prerequisites (incomplete): xrootd
+
+# Installing on OSX
+Setup should succeed if:
+ - xrootd is installed on your system
+ - xrootd was installed via homebrew
+ - you're installing the bindings package with the same version number as the
+   xrootd installation (`xrootd -v`).
+
+If you have xrootd installed and the installation still fails, do
+`XRD_LIBDIR=XYZ; XRD_INCDIR=ZYX; pip install xrootd`
+where XYZ and ZYX are the paths to the XRootD library and include directories on your system.
+
+## How to find the lib and inc directories
+To find the library directory, search your system for "libXrd*" files.
+The include directory should contain a file named "XrdVersion.hh", so search for that.
diff --git a/bindings/python/setup_pypi.py b/bindings/python/setup_pypi.py
new file mode 100644
index 00000000000..2830e2d7c29
--- /dev/null
+++ b/bindings/python/setup_pypi.py
@@ -0,0 +1,67 @@
+from distutils.core import setup, Extension
+from distutils import sysconfig
+from os import getenv, walk, path, path, getcwd, chdir
+from platform import system
+import subprocess
+
+# Remove the "-Wstrict-prototypes" compiler option, which isn't valid for C++.
+cfg_vars = sysconfig.get_config_vars()
+opt = cfg_vars["OPT"]
+cfg_vars["OPT"] = " ".join( flag for flag in opt.split() if flag != '-Wstrict-prototypes' )
+
+
+sources = list()
+depends = list()
+
+for dirname, dirnames, filenames in walk('src'):
+  for filename in filenames:
+    if filename.endswith('.cc'):
+      sources.append(path.join(dirname, filename))
+    elif filename.endswith('.hh'):
+      depends.append(path.join(dirname, filename))
+
+# Get package version
+with open ('VERSION_INFO') as verfile:
+    version = verfile.read().strip()
+
+def getincdir_osx():
+    # Assume xrootd was installed via homebrew
+    return '/usr/local/Cellar/xrootd/{0}/include/xrootd'.format(version)
+
+def getlibdir():
+    return (system() == 'Darwin' and '/usr/local/lib') or '/usr/lib'
+
+def getincdir():
+    return (system() == 'Darwin' and getincdir_osx()) or '/usr/include/xrootd'
+
+xrdlibdir = getenv( 'XRD_LIBDIR' ) or getlibdir()
+xrdincdir = getenv( 'XRD_INCDIR' ) or getincdir()
+
+print 'XRootD library dir: ', xrdlibdir
+print 'XRootD include dir: ', xrdincdir
+print 'Version:            ', version
+
+setup( name             = 'pyxrootd',
+       version          = version,
+       author           = 'XRootD Developers',
+       author_email     = 'xrootd-dev@slac.stanford.edu',
+       url              = 'http://xrootd.org',
+       license          = 'LGPLv3+',
+       description      = "XRootD Python bindings",
+       long_description = "XRootD Python bindings",
+       packages         = ['pyxrootd', 'XRootD', 'XRootD.client'],
+       package_dir      = {'pyxrootd'     : 'src',
+                           'XRootD'       : 'libs',
+                           'XRootD.client': 'libs/client'},
+       ext_modules      = [
+           Extension(
+               'pyxrootd.client',
+               sources   = sources,
+               depends   = depends,
+               libraries = ['XrdCl', 'XrdUtils', 'dl'],
+               extra_compile_args = ['-g'],
+               include_dirs = [xrdincdir],
+               library_dirs = [xrdlibdir]
+               )
+           ]
+       )
diff --git a/dopy.sh b/dopy.sh
new file mode 100755
index 00000000000..2f870ad8dc2
--- /dev/null
+++ b/dopy.sh
@@ -0,0 +1,10 @@
+#!/bin/bash
+# Writes the xrootd version to bindings/python/VERSION_INFO,
+# generates and uploads a source distribution for the python bindings.
+./genversion.sh --print-only | sed "s/v//" > bindings/python/VERSION_INFO
+cd bindings/python
+cp setup_pypi.py setup.py
+python setup.py sdist
+twine upload dist/*
+rm setup.py dist/*
+