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IBMA (Image-based meta-analysis)
With statistical maps of different datasets tested using same analysis pipeline, and the demography of each sample, users can perform meta-analysis to merge the multisite statistics using image-based or matrix-based meta-analysis. We have implemented Stouffer's z-score method, Fisher's method, fixed/mixed effects model, Worsley and Friston's method and Nichols' method.
.. image:: _images/ibma.png
:align: right
* **data**: matrix
* **filetype**: files in the filetype will be searched in input directories.
* **data dir**: directory where all :file:`ttest2\*.mat` results are stored.
* **data**: volume
* **center info**: number of subjects for different centers. A csv format table is required. N1 and N2 is the number of subjects in each group.
====================== === ===
center N1 N2
====================== === ===
ttest2_center1_a_vs_b 40 39
ttest2_center2_a_vs_b 38 37
====================== === ===
* **mask**: could be whole brain mask or gray matter mask.
* **id index**: identifier to find unique string for each subject
* **filetype**: files in the filetype will be searched in input directories.
* **data dir**: directories can be input either using a :file:`\*.txt` file or spm select window.
* **Multiple comparison correction methods (voxel-wise)**
* **threshold**: the level of MULCC
* **fdrID**: false discovery rate (independent input)
* **fdrN**: false discovery rate (inputs not independent)
* **bonf**: Bonferroni correction for family wise error rate
* **IBMA Methods**:
* `Stouffer's z-score`_
* `Fisher's method`_
* `Fixed Effects Model`_
* `Mixed Effects Model`_
* `Friston's method`_
* `Nichols's method`_
.. _`Stouffer's z-score`:
.. _`Fisher's method`:
.. _`Fixed Effects Model`:
.. _`Mixed Effects Model`:
.. _`Friston's method`:
.. _`Nichols's method`:
* **out dir**: output directory for saving results.
- **Buttons**:
- **S**: Save parameters of the current panel to a :file:`\*.mat` file. The :file:`\*.mat` can be further loaded for the panel or be used in a script processing.
- **L**: Load parameters from :file:`\*.mat` for the current panel.
- **?**: Help information.
* **References**:
1. Stouffer's z-score
Stouffer, S.A., Suchman, E.A., DeVinney, L.C., Star, S.A. and Williams Jr, R.M., 1949. *The American soldier: Adjustment during army life.(Studies in social psychology in World War II), Vol. 1*. Princeton University Press, Princeton,.
2. Fisher
Fisher, R.A. (1925). Statistical Methods for Research Workers. *Oliver and Boyd (Edinburgh)*. ISBN 0-05-002170-2.
3. Fixed/mixed Effects Model
Hedges, L.V. (1992). Meta-Analysis. *Journal of Educational and Behavioral Statistics.* 17(4), 279-296. doi: 10.3102/10769986017004279.
Konstantopoulos, S. (2006). Fixed and mixed effects models in meta-analysis. *Iza Discussion Papers*.
4. Worsley and Friston's method
Worsley, K.J., and Friston, K.J. (2000). A test for a conjunction. *Statistics & Probability Letters.* 47(2), 135-140. doi: 10.1016/S0167-7152(99)00149-2.
5. Nichols's method
Nichols, T., Brett, M., Andersson, J., Wager, T., and Poline, J.B. (2005). Valid conjunction inference with the minimum statistic. *Neuroimage.* 25(3), 653-660. doi: 10.1016/j.neuroimage.2004.12.005.
6. Salimi-Khorshidi G, Smith SM, Keltner JR, Wager TD, Nichols TE. Meta-analysis of neuroimaging data: a comparison of image-based and coordinate-based pooling of studies. *Neuroimage 2009*; 45(3): 810-23.
7. Benjamini Y, Hochberg Y. Controlling the False Discovery Rate - a Practical and Powerful Approach to Multiple Testing. J Roy Stat Soc B Met 1995; 57(1): 289-300.
8. Benjamini Y, Yekutieli D. The control of the false discovery rate in multiple testing under dependency. Ann Stat 2001; 29(4): 1165-88.
9. Lazar NA, Luna B, Sweeney JA, Eddy WF. Combining brains: a survey of methods for statistical pooling of information. *Neuroimage 2002*; 16(2): 538-50.