[Errno 13] Permission denied, unable to open for writing

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Question

Setup youtube-dl.conf under C:\Users\User, only -o ~/Desktop in the file
Run youtube-dl and got ERROR: unable to open for writing: [Errno 13] Permission denied: 'C:\\Users\\user\\Desktop'
Have searched several similar posts. The right-click -> properties -> security setting permits all access to Desktop file. Using -o ~/tmp creates a file named tmp, not a video in tmp folder.

Thanks for reply.

-v code here

C:\Program Files>youtube-dl https://www.youtube.com/watch?v=l4zkc7KEvYM -v
[debug] System config: []
[debug] User config: ['-o', '~/Desktop']
[debug] Custom config: []
[debug] Command-line args: ['https://www.youtube.com/watch?v=l4zkc7KEvYM', '-v']
[debug] Encodings: locale cp65001, fs mbcs, out cp65001, pref cp65001
[debug] youtube-dl version 2020.07.28
[debug] Python version 3.4.4 (CPython) - Windows-10-10.0.18362
[debug] exe versions: none
[debug] Proxy map: {}
[youtube] l4zkc7KEvYM: Downloading webpage
[youtube] {18} signature length 111, html5 player eecb0f1e
[youtube] {136} signature length 111, html5 player eecb0f1e
[youtube] {247} signature length 111, html5 player eecb0f1e
[youtube] {398} signature length 107, html5 player eecb0f1e
[youtube] {135} signature length 107, html5 player eecb0f1e
[youtube] {244} signature length 111, html5 player eecb0f1e
[youtube] {397} signature length 111, html5 player eecb0f1e
[youtube] {134} signature length 107, html5 player eecb0f1e
[youtube] {243} signature length 111, html5 player eecb0f1e
[youtube] {396} signature length 111, html5 player eecb0f1e
[youtube] {133} signature length 111, html5 player eecb0f1e
[youtube] {242} signature length 111, html5 player eecb0f1e
[youtube] {395} signature length 111, html5 player eecb0f1e
[youtube] {160} signature length 111, html5 player eecb0f1e
[youtube] {278} signature length 111, html5 player eecb0f1e
[youtube] {394} signature length 111, html5 player eecb0f1e
[youtube] {140} signature length 111, html5 player eecb0f1e
[youtube] {249} signature length 111, html5 player eecb0f1e
[youtube] {250} signature length 111, html5 player eecb0f1e
[youtube] {251} signature length 111, html5 player eecb0f1e
[debug] Default format spec: best/bestvideo+bestaudio
[debug] Invoking downloader on 'https://r5---sn-i3b7knld.googlevideo.com/videoplayback?expire=1598524166&ei=pjZHX_L3DsmqlQS2wIn4DQ&ip=203.218.193.14&id=o-AJ8D1A3ni5y2TtNs6jYnQb5YrX_g04x6r5PuUXwd_asD&itag=18&source=youtube&requiressl=yes&mh=Ci&mm=31%2C26&mn=sn-i3b7knld%2Csn-aigl6nek&ms=au%2Conr&mv=m&mvi=5&pl=19&gcr=hk&initcwndbps=1442500&vprv=1&mime=video%2Fmp4&gir=yes&clen=184774808&ratebypass=yes&dur=2320.462&lmt=1572695135054173&mt=1598502396&fvip=5&c=WEB&txp=1311222&sparams=expire%2Cei%2Cip%2Cid%2Citag%2Csource%2Crequiressl%2Cgcr%2Cvprv%2Cmime%2Cgir%2Cclen%2Cratebypass%2Cdur%2Clmt&lsparams=mh%2Cmm%2Cmn%2Cms%2Cmv%2Cmvi%2Cpl%2Cinitcwndbps&lsig=AG3C_xAwRgIhANBH96iLCJOs47HAeHTND52exG24tPIww7J31ENyTzKbAiEA7pEgW5W3CXMN7A7m8bOpShmmtn-xZMd3eENHvNCZgbU%3D&sig=AOq0QJ8wRQIgf2ZKCgi73KP6nk807MKoFgLV0BKZ8MY4Vp9dr0oV7a4CIQDxHkh-jyCs-4NiD366f3yA6gL6Uw3OoHoSIVD0p0qPZg=='
ERROR: unable to open for writing: [Errno 13] Permission denied: 'C:\\Users\\user\\Desktop'
Traceback (most recent call last):
  File "C:\Users\dst\AppData\Roaming\Build archive\youtube-dl\ytdl-org\tmpq2whuxta\build\youtube_dl\downloader\http.py", line 250, in download
  File "C:\Users\dst\AppData\Roaming\Build archive\youtube-dl\ytdl-org\tmpq2whuxta\build\youtube_dl\utils.py", line 2054, in sanitize_open
PermissionError: [Errno 13] Permission denied: 'C:\\Users\\user\\Desktop'