diff --git a/samples/sensor/hs300x/CMakeLists.txt b/samples/sensor/hs300x/CMakeLists.txt
new file mode 100644
index 000000000000000..6f5eabb9d8cee21
--- /dev/null
+++ b/samples/sensor/hs300x/CMakeLists.txt
@@ -0,0 +1,8 @@
+# SPDX-License-Identifier: Apache-2.0
+
+cmake_minimum_required(VERSION 3.20.0)
+find_package(Zephyr REQUIRED HINTS $ENV{ZEPHYR_BASE})
+project(hs300x)
+
+FILE(GLOB app_sources src/*.c)
+target_sources(app PRIVATE ${app_sources})
diff --git a/samples/sensor/hs300x/README.rst b/samples/sensor/hs300x/README.rst
new file mode 100644
index 000000000000000..345b0969a94dd37
--- /dev/null
+++ b/samples/sensor/hs300x/README.rst
@@ -0,0 +1,65 @@
+.. _hs300x_sample:
+
+HS300X Sample
+#############
+
+Description
+***********
+
+This sample application periodically takes temperature and humidity readings
+using the renesas_hs300x sensor driver. The result is written to the console.
+The HS3001 and HS3003 sensors are supported by the same application and driver.
+
+Requirements
+************
+
+This sample needs a Renesas HS3001 or HS3003 sensor connected to the target
+board's I2C connector.
+
+Wiring
+******
+
+This sample has been tested with Nucleo STM32F401RE board. A click shield for
+NUCLEO-64 was used to connect TEMP&HUM 17 click and TEMP&HUM 18 click boards to
+the STM32F401RE board.
+
+The sensor operates at 3.3V and uses I2C to communicate with the board.
+
+External Wires:
+
+* Breakout **GND** pin <--> Nucleo **GND** pin
+* Breakout **VCC** pin <--> Nucleo **3V3** pin
+* Breakout **SDA** pin <--> Nucleo **CN5-D14** pin
+* Breakout **SCL** pin <--> Nucleo **CN5-D15** pin
+
+Building and Running
+********************
+
+In order to build the sample, connect the board to the computer with a USB cable
+and enter the following commands:
+
+.. zephyr-app-commands::
+   :zephyr-app: samples/sensor/hs300x
+   :board: nucleo_f401re
+   :goals: build flash
+   :compact:
+
+Sample Output
+*************
+The output can be seen via a terminal emulator (e.g. minicom). Connect the board
+with a USB cable to the computer and open /dev/ttyACM0 with the below serial
+settings:
+
+* Baudrate: 115200
+* Parity: None
+* Data: 8
+* Stop bits: 1
+
+The output should look like this:
+
+.. code-block:: console
+
+    Device HS300x - 0x200010a8 is ready
+    temp is 26.70 oC
+    hum is 50.71 %RH
+    ...
diff --git a/samples/sensor/hs300x/boards/nucleo_f401re.overlay b/samples/sensor/hs300x/boards/nucleo_f401re.overlay
new file mode 100644
index 000000000000000..9223c61c6937014
--- /dev/null
+++ b/samples/sensor/hs300x/boards/nucleo_f401re.overlay
@@ -0,0 +1,14 @@
+/*
+ * Copyright (c) 2023 Ian Morris
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+ &i2c1 {
+	renesas_hs300x: renesas_hs300x@44 {
+		compatible = "renesas,hs300x";
+		reg = <0x44>;
+		#address-cells = <1>;
+		#size-cells = <0>;
+	};
+};
diff --git a/samples/sensor/hs300x/prj.conf b/samples/sensor/hs300x/prj.conf
new file mode 100644
index 000000000000000..4cea5f1b3e0b9b9
--- /dev/null
+++ b/samples/sensor/hs300x/prj.conf
@@ -0,0 +1,4 @@
+CONFIG_STDOUT_CONSOLE=y
+CONFIG_I2C=y
+CONFIG_SENSOR=y
+CONFIG_SENSOR_INIT_PRIORITY=90
diff --git a/samples/sensor/hs300x/sample.yaml b/samples/sensor/hs300x/sample.yaml
new file mode 100644
index 000000000000000..77d06d05c7933d1
--- /dev/null
+++ b/samples/sensor/hs300x/sample.yaml
@@ -0,0 +1,21 @@
+#
+# Copyright (c) 2023 Ian Morris
+#
+# SPDX-License-Identifier: Apache-2.0
+
+sample:
+  name: Renesas HS300x Sensor Sample
+tests:
+  sample.sensor.hs300x:
+    harness: console
+    platform_allow: nucleo_f401re
+    integration_platforms:
+      - nucleo_f401re
+    tags: sensors
+    depends_on: i2c
+    harness_config:
+      type: multi_line
+      regex:
+        - "temp is (.*) oC"
+        - "hum is (.*) %RH"
+      fixture: fixture_i2c_hs300x
diff --git a/samples/sensor/hs300x/src/main.c b/samples/sensor/hs300x/src/main.c
new file mode 100644
index 000000000000000..05bdc86fb61f1af
--- /dev/null
+++ b/samples/sensor/hs300x/src/main.c
@@ -0,0 +1,41 @@
+/*
+ * Copyright (c) 2023 Ian Morris
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+#include <zephyr/kernel.h>
+#include <zephyr/device.h>
+#include <zephyr/drivers/sensor.h>
+#include <zephyr/sys/printk.h>
+#include <zephyr/sys/__assert.h>
+
+#define HS300X_NODE DT_COMPAT_GET_ANY_STATUS_OKAY(renesas_hs300x)
+
+int main(void)
+{
+	const struct device *const dev = DEVICE_DT_GET(HS300X_NODE);
+	struct sensor_value temp, hum;
+	int ret;
+
+	__ASSERT(device_is_ready(dev), "HS300x device not ready");
+
+	printk("Device %s - %p is ready\n", dev->name, dev);
+
+	while (1) {
+		ret = sensor_sample_fetch(dev);
+		if (ret) {
+			printk("Failed to fetch measurements (%d)\n", ret);
+			return 0;
+		}
+
+		sensor_channel_get(dev, SENSOR_CHAN_AMBIENT_TEMP, &temp);
+		sensor_channel_get(dev, SENSOR_CHAN_HUMIDITY, &hum);
+
+		printk("temp is %d.%d oC\n", temp.val1, temp.val2);
+		printk("hum is %d.%d %%RH\n", hum.val1, hum.val2);
+
+		k_sleep(K_MSEC(1000));
+	}
+	return 0;
+}