diff --git a/CHANGES.txt b/CHANGES.txt
index 9199889..a583ef1 100644
--- a/CHANGES.txt
+++ b/CHANGES.txt
@@ -4,6 +4,8 @@ Changelog
 4.2.0 (unreleased)
 ------------------
 
+- Drop support for ``python setup.py test``.
+
 - Add support for Python 3.8.
 
 - Drop support for Python 3.4.
diff --git a/setup.py b/setup.py
index a945401..7c191b0 100644
--- a/setup.py
+++ b/setup.py
@@ -79,10 +79,6 @@ def read(*rnames):
             'zope.testrunner',
         ]
     ),
-    setup_requires=[
-        'eggtestinfo',
-        'zope.testrunner',
-    ],
     install_requires=[
         'ZODB',
         'zdaemon',
@@ -106,8 +102,6 @@ def read(*rnames):
         'zope.testing >= 3.10',
         'zope.testrunner',
     ],
-    test_suite='zope.app.appsetup.tests.test_suite',
-    test_loader='zope.testrunner.eggsupport:SkipLayers',
     include_package_data=True,
     zip_safe=False,
     entry_points="""